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Open Access

Correction

Correction: Myeloid derived suppressor cells contribute to the malignant progression of oral squamous cell carcinoma

  • Xin Pang,
  • Hua-yang Fan,
  • Ya-ling Tang,
  • Sha-sha Wang,
  • Ming-xin Cao,
  • Hao-fan Wang,
  • Lu-ling Dai,
  • Ke Wang,
  • Xiang-hua Yu,
  • Jing-biao Wu,
  • Ya-Jie Tang,
  • Xin-hua Liang

After this article [1] was published, concerns were raised with Figs 3 and 5. Specifically:

  • In Fig 3A, the Cal-27 MDSC(O) 0h panel appears to overlap with the Cal-27 Control 0h and Cal-27 MDSC(H) 0h panels.
  • In Fig 5A, the Cal-27 Control 24h and Cal-27 MDSC(H) 24h panels appear to overlap.
  • In Fig 5A, the SCC-25 MDSC(O) 48h panel appears to overlaps with the SACC-LM 48h panel in Fig 2A of [2], and these panels appear to represent different cell lines.

Co-first author XP stated that all three of the Cal-27 0h panels in Fig 3A are incorrect. They provided an updated version of Fig 3 with the correct Cal-27 0h panels in Fig 3A from the original experiments reported in [1]. The underlying data for Fig 3 are provided here in S1 and S3 Files.

Co-first author XP stated that the Cal-27 MDSC(H) 24h panel in Fig 5A is incorrect. They provided an updated version of Fig 5 with the correct Cal-27 MDSC(H) 24h panel in Fig 5A from the original experiments reported in [1]. The underlying data for Fig 5 are provided here in S2 File. Co-first author XP also stated that the SCC-25 MDSC(O) 48h panel in Fig 5A of [1] is correct and the SACC-LM 48h panel in Fig 2A of [2] is incorrect.

A member of the PLOS One Editorial Board reviewed the updated Figs 3 and 5 and stated that they support the results in [1].

The raw data underlying Figs 1-6 are missing from the list of Supporting Information. The authors have provided the data as Supporting Information S1-S4 Files. With this correction, all relevant data are now provided.

The SCC-25 MDSC(O) 48h panel in Fig 5A in [1] appears similar to content previously published in [2] under a CC BY license. The reused content was modified. The SCC-25 MDSC(O) 48h panel in Fig 5A in [1] is subject to the license that applies to the original article; please provide due attribution to the original publication when referring to this content.

Supporting information

S1 File. Individual-level underlying data and images for Fig 3B, and underlying image for the corrected Fig 3A.

https://doi.org/10.1371/journal.pone.0355520.s001

(ZIP)

S2 File. Individual-level underlying data and images for Fig 5B, and underlying image for the corrected Fig 5A.

https://doi.org/10.1371/journal.pone.0355520.s002

(ZIP)

S3 File. Individual-level underlying quantitative data for Figs 1B-C, 2A, 2B (SCC-25), 2C, 4B-C, 6A-B, and for the corrected Fig 3A.

https://doi.org/10.1371/journal.pone.0355520.s003

(RAR)

S4 File. Individual-level underlying quantitative data for Fig 2B (Cal-27).

https://doi.org/10.1371/journal.pone.0355520.s004

(RAR)

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Fig 3. Tumor-associated MDSCs promoted migration and invasion on OSCC cells.

A. Migration assay examined the cell migration ability in control and MDSCs co-culture group of Cal-27 and SCC-25, respectively. Representative figures were shown. The migration ability of OSCC cells co-cultured with OSCC MDSCs was significantly enhanced compared with the control or OSCC cells co-cultured with MDSCs from health donors. The mean was derived from cell counts of 3 fields, and each experiment was repeated 3 times. Error bars represent the mean ± SD of triplicate experiments. *P < 0.05. B. Invasion assay examined the cell invasion ability in control and MDSCs co-culture group of Cal-27 and SCC-25, respectively. Representative figures were shown. The invasion ability of OSCC cells co-cultured with OSCC MDSCs was significantly increased compared with control or OSCC cells co-cultured with MDSCs from health donors. The mean was derived from cell counts of 3 fields, and each experiment was repeated 3 times. Error bars represent the mean ± SD of triplicate experiments. *P < 0.05.

https://doi.org/10.1371/journal.pone.0355520.g003

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Fig 5. Tumor-associated MDSCs promoted VM of OSCC cells.

A. Tube-like structure formation on Matrigel in Cal 27 and SCC-25 cells. OSCC cells co-cultured with OSCC derived MDSCs showed a stronger ability of VM formation compared with the control and cells co-cultured with health MDSCs. B. Immunofluorescence staining and RT-PCR assessed the effect of MDSCs on VE-cadherin protein and mRNA expression in OSCC cell lines, respectively. The data showed that OSCC derived MDSCs enhanced the level of VE-cadherin in SACC cells in both protein and mRNA levels. Error bars represent the mean ± SD of triplicate experiments. * P < 0.05.

https://doi.org/10.1371/journal.pone.0355520.g005

References

  1. 1. Pang X, Fan H-y, Tang Y-l, Wang S-s, Cao M-x, Wang H-f, et al. Myeloid derived suppressor cells contribute to the malignant progression of oral squamous cell carcinoma. PLoS One. 2020;15(2):e0229089.
  2. 2. Wang H-F, Wang S-S, Zheng M, Dai LL, Wang K, Gao XL, et al. Hypoxia promotes vasculogenic mimicry formation by vascular endothelial growth factor A mediating epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. Cell Prolif. 2019;52:e12600.

Citation: Pang X, Fan H-y, Tang Y-l, Wang S-s, Cao M-x, Wang H-f, et al. (2026) Correction: Myeloid derived suppressor cells contribute to the malignant progression of oral squamous cell carcinoma. PLoS One 21(8): e0355520. https://doi.org/10.1371/journal.pone.0355520

Published: August 10, 2026

Copyright: © 2026 Pang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.