The PLOS One Editors retract this article [1,2] due to concerns about potential manipulation of the publication process. These concerns call into question the validity and provenance of the reported results. We regret that the issues were not identified prior to the article’s publication.
TW and QZ did not agree with the retraction. XJ, YY, XW, YG, and YF either did not respond directly or could not be reached.
References
- 1. Wu T, Ji X, Yun Y, Wang X, Gan Y, Fan Y, et al. RETRACTED: SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway. PLoS One. 2025;20(10):e0333202. pmid:41042741
- 2. Wu T, Ji X, Yun Y, Wang X, Gan Y, Fan Y, et al. Correction: SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway. PLoS One. 2026;21(3):e0345024. pmid:41824384
Citation: The PLOS One Editors (2026) Retraction: SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway. PLoS One 21(5): e0349920. https://doi.org/10.1371/journal.pone.0349920
Published: May 22, 2026
Copyright: © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.