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Editorial Note

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Editorial Note: Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles

  • The PLOS One Editors

The PLOS One Editors issue this Editorial Note to inform readers of similarities between images originally published in this article [1] and those in three later‑published articles [2–4] by some of the same authors, all of which have since been retracted.

Specifically, the following similarities were identified between panels with differently labelled samples and/or conditions:

  • The AT8 3xTg-zileuton panel in Fig 3D of [1] appears similar to the AT8 htau-zileuton panel in Fig 3F of [2].
  • The AT180 3xTg panel in Fig 3D of [1] appears similar to the AT180 htau panel in Fig 3F of [2].
  • The MAP2 3xTg panel in Fig 4E of [1] appears similar to the MAP2 WT and MAP2 WT‑zileuton panels in Fig 5C of [3].
  • The PSD-95 3xTg‑zileuton panel in Fig 4E of [1] appears similar to the PSD-95 WT-5LO panel in Fig 4C of [4].

The corresponding author states that the correct experimental information is reported in this article [1], which precedes other articles containing duplicate material.

References

  1. 1. Chu J, Li J-G, Praticò D. Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer’s disease with plaques and tangles. PLoS One. 2013;8(8):e70991. pmid:23951061
  2. 2. Giannopoulos PF, Chu J, Sperow M, Li J-G, Yu WH, Kirby LG, et al. RETRACTED: Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy. Biol Psychiatry. 2015;78(10):693–701. pmid:25802082
  3. 3. Giannopoulos PF, Chiu J, Praticò D. RETRACTED ARTICLE: Learning impairments, memory deficits, and neuropathology in aged tau transgenic mice are dependent on leukotrienes biosynthesis: role of the cdk5 kinase pathway. Mol Neurobiol. 2019;56(2):1211–20. pmid:29881943
  4. 4. Giannopoulos PF, Praticò D. RETRACTED ARTICLE: overexpression of 5-lipoxygenase worsens the phenotype of a mouse model of tauopathy. Mol Neurobiol. 2018;55(7):5926–36. pmid:29128902

Citation: The PLOS One Editors (2026) Editorial Note: Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles. PLoS One 21(5): e0349725. https://doi.org/10.1371/journal.pone.0349725

Published: May 20, 2026

Copyright: © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.