Figures
Abstract
Objective
Integrative Neuromuscular Training (INT) is recognized not only for its potential in preventing sports injuries but also for enhancing athletic performance. Understanding the relationship between INT and the physical qualities of elite Sanda athletes is important for addressing performance limitations in elite Sanda athletes. While INT has been applied in various sports, there is a lack of research in the context of Sanda. This empirical study aims to investigate the effects of INT on the physical qualities of elite Sanda athletes.
Methods
A randomized controlled trial design was employed, with 26 elite male Sanda athletes randomly assigned to either the Integrative Neuromuscular Training group (INT, n = 13) or the control group (CON, n = 13). The INT group engaged in three sessions of INT training per week, lasting 45 minutes each for 12 weeks, while the CON group completed a conventional conditioning program. Pre- and post-intervention assessments included one-repetition maximum tests (1RM), 30-meter sprint tests (30MST), counter movement jump tests (CMJ), reaction agility tests (RAT), and Y balance tests (YBT).
Results
Post-intervention, the INT group showed significant improvements in these physical fitness measures: [1RM bench press (p < 0.001, d = 2.599), 1RM squat (p < 0.001, d = 2.610), T-5m (p = 0.011, d = −1.000), T-10m (p = 0.011, d = −0.833), T-30m (p < 0.001, d = −6.120), CMJ (p < 0.001, d = 4.236), RAT (p < 0.001, d = −3.312), YBT-L (p < 0.001, d = 3.075), YBT-R (p < 0.001, d = 2.722)]. In the CON group, there were no significant changes in physical quality test scores post-intervention. Relative changes from pre- to post-intervention indicated no significant differences in △-T-5m between INT and CON groups, while significant differences were found in other physical quality assessments [△-1RM bench press (3.376 vs 0.220 kg, p < 0.001), △-1RM squat (3.665 vs −0.533 kg, p < 0.001), △-T-10m (−0.005 vs 0.005 s, p = 0.004), △-T-30m (−0.153 vs −0.017 s, p < 0.001), △-CMJ (4.846 vs 0.615 cm, p < 0.001), △-RAT (−0.048 vs −0.002 s, p < 0.001), △-YBT-L (5.154 vs −0.615, p < 0.001), △-YBT-R (5.615 vs −0.308, p < 0.001)].
Conclusion
A 12-week INT intervention significantly enhances the physical qualities of Sanda athletes. The overall improvements in the INT group across 1RM, 30MST, CMJ, RAT, and YBT tests demonstrate that the INT program may serve as an effective conditioning strategy for improving selected physical fitness outcomes in elite Sanda athletes.
Citation: Li Z, Sun J, Muszali R, Li L (2026) The impact of integrative neuromuscular training on the physical fitness of elite male martial arts Sanda Athletes. PLoS One 21(5): e0349164. https://doi.org/10.1371/journal.pone.0349164
Editor: Danica Janicijevic, University of Belgrade: Univerzitet u Beogradu, SERBIA
Received: January 27, 2026; Accepted: April 25, 2026; Published: May 18, 2026
Copyright: © 2026 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the manuscript and its Supporting information files.
Funding: The author(s) received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
1 Introduction
Martial arts sanda, also known as martial arts sanshou, is a branch of martial arts that employs various offensive and defensive techniques, including striking, kicking, and grappling, to overcome opponents in a highly competitive, unarmed combat setting [1]. This sport demands exceptional physical attributes, such as agility, flexibility, stability, and neuromuscular control. However, due to the specificity of its technical movements, training content, and competition requirements, the incidence of sports injuries is notably high [2,3]. To secure victory in competitions, athletes must adeptly select relevant stimuli to anticipate attacks and determine optimal counteractions against opponents, highlighting the critical importance of enhancing athletes’ perceptual and cognitive abilities [4]. As the Sanda discipline continues to evolve, competition has accelerated, necessitating athletes to perform spontaneous, high-frequency technical maneuvers along with increased foot movement and tactical transitions. Consequently, agility has emerged as a vital factor influencing both the development of Sanda and the determinants of competitive success [5]. Excellent physical fitness not only ensures that athletes can execute complex techniques and enhance the quality of their performance but also that flexibility and stability allow for unrestricted movement and prevent excessive compensation during actions. This contributes to the efficient execution of technical movements, effectively reduces the risk of injuries, and plays a significant role in extending an athlete's career [2,6]. In addition to agility, balance, and neuromuscular control, strength, and explosive power are equally crucial for athletic performance [7]. Elite athletes often encounter performance bottlenecks [8], and after prolonged periods of intense training, they may experience sports injuries and psychological burnout. This underscores the necessity for efficient training methods or schedules to address performance obstacles and enhance overall physical fitness and athletic performance [9].
Integrative Neuromuscular Training (INT) is recognized as a comprehensive training approach aimed at enhancing athletic performance and preventing sports injuries. It encompasses a combination of general foundational functional movement training and specific strength, plyometric, speed, agility, and balance training. INT programs have been shown to significantly improve muscle recruitment patterns, postural stability, and dynamic lower limb balance [10]. This training intervention also seeks to develop athletes’ perceptual and cognitive abilities during physical activities, offering a more refined and precise methodology compared to traditional, broad-based physical conditioning [11–13]. While injury prevention remains a key objective, coaches and athletes primarily favor the adoption of INT programs to enhance athletic performance [14]. Currently, INT training methods have been widely implemented across various sports, including football [15], basketball [16], volleyball [17], floorball [18], and table tennis [19], to improve athletes’ physical conditioning. However, there is a notable lack of practical research on the application of Integrative Neuromuscular Training specifically for elite martial arts athletes engaged in Sanda.
This study aims to explore the effects of Integrative Neuromuscular Training (INT) on strength, speed, lower limb explosive power, reactive agility, coordination, and balance in elite male Chinese Sanda athletes through experimental intervention, thereby addressing this research gap. It seeks to investigate the relationship between INT and physical fitness, offering a solution for elite Sanda athletes to overcome performance bottlenecks in physical conditioning. Furthermore, this research intends to provide scientific evidence and practical guidance for enhancing athletes’ physical capabilities and performance while effectively preventing sports injuries.
2 Materials and methods
2.1 Participants
A total of 26 participants (2 international-level athletes, 3 national-level athletes, and 21 national first-level athletes) completed all tests in this study (see Table 1). The study employed a parallel design, with participants randomly assigned in a 1:1 ratio to either the experimental intervention group (INT, n = 13) or the control group (CON, n = 13). All participants were physically healthy, injury-free, non-smokers, and voluntarily participated in this study. Informed consent was obtained after they were briefed on the testing procedures and potential risks. Participants were recruited between 01/11/2024 and 29/11/2024. Participants were randomly assigned in a 1:1 ratio using a computerized random number generator with concealed allocation (sequentially numbered, sealed opaque envelopes) to ensure group concealment before baseline assessment. The research protocol was approved by the Sports Science Experiment Ethics Committee of Beijing Sport University (Approval No. 2023352H). The clinical trial titled ‘The Impact of Integrative Neuromuscular Training on the Physical Fitness of Elite Male Martial Arts Sanda Athletes’ was registered with the Chinese Clinical Trial Registry (ChiCTR) under registration number ChiCTR2400092688 on 21/11/2024. Participants were recruited from different competitive levels; however, random allocation was used and no significant between-group differences were observed in demographic characteristics or baseline performance variables prior to the intervention, which may have partly minimized the influence of participant heterogeneity on the between-group comparisons.
2.2 Procedures
This study employed a randomized controlled trial design, consisting of four phases (see Fig 1). The first phase involved preparing the experimental setup, during which participants became familiar with all testing procedures, the testing environment, equipment, and the content of the Integrative Neuromuscular Training (INT). Basic participant information was collected and measured during this phase. The second phase was the first testing period, and the fourth phase was the second testing period. Both testing periods included assessments of one maximum repetition (1RM), a 30-meter sprint, counter-movement jump (CMJ), reactive agility, and Y-balance tests. The third phase constituted the intervention phase. A 72hour (3 day) recovery interval was implemented between baseline maximal exertion testing and the first intervention session to eliminate residual neuromuscular fatigue. During the 12-week intervention, both groups trained three times per week, with each session lasting 45 minutes and being performed after a standardized warm-up and before regular Sanda practice. The INT group completed a progressive integrative neuromuscular training program consisting of reaction and agility, speed and coordination, core stability and balance, strength, and plyometric modules. The CON group completed a conventional conditioning program routinely used in Sanda training, primarily including jogging, solo striking practice, and paired target-striking drills. Detailed week-by-week training content, loading, repetitions, and sets for both groups are now provided in Appendix S1.
2.3 Testing protocols and measurements
Before testing, all participants completed a standardized warm-up routine, as referenced in previous studies [20]. This routine included 3 minutes of low-intensity jogging followed by static stretching exercises targeting the quadriceps, hamstrings, gastrocnemius, gluteal muscles, and hip adductors, with each stretch held for 15 seconds. Subsequently, participants performed dynamic stretching using squats, leg swings, and other specific exercises typically employed by sprinters. To conclude the warm-up, participants executed two maximal-effort 30-meter sprints. Following the warm-up, all tests were conducted sequentially in an indoor facility, with participants permitted to sit quietly or walk slowly during the intervals between tests. All assessors were blinded to group allocation throughout pre‑ and post‑intervention testing to minimize detection bias.
2.3.1 1RM strength assessment.
The One-Repetition Maximum (1RM) Strength Assessment is utilized to evaluate maximal strength. The testing protocol begins with participants performing squats using a predetermined weight that is below their estimated 1RM. The total weight is then progressively increased in increments of 1–10 kg based on the participant's feedback. During the squat, participants are required to maintain a fixed foot stance and toe angle, ensuring that the knees do not extend beyond the toes and that the thighs reach a parallel position to the ground [21]. A rest period of 2 minutes is allowed between consecutive trials. The final weight that a participant can lift for a single repetition is recorded as their 1RM. All participants successfully determined their 1RM after completing 3–5 trials. The procedure for the bench press test mirrors that of the squat, with participants instructed to lower the barbell to the chest before pressing it upward until their arms are fully extended [22].
2.3.2 30-meter sprint test.
The 30-meter Sprint Test (30MST) is employed to assess speed performance. Following established protocols [20], the test is conducted on an indoor synthetic straight track, utilizing laser measurement equipment (LAVEG, Jenoptik, Sport) to acquire linear distance measurements at a sampling frequency of 100 Hz throughout all trials. The laser measurement procedures align with the recommendations set forth by Harrison et al. [23]. A 30-meter track is marked with a clearly defined starting line and finish line, with the laser mounted on a tripod at a height of 1.37 meters, positioned 2 meters behind the starting line. Participants are instructed to wear fitted white T-shirts to enhance the reflection of the laser signal. The laser is aimed at each participant's lower back. At the starting line, a research assistant signals the beginning of the test with a whistle, while another assistant records the time at the finish line using a stopwatch with a precision of 0.01 seconds. The testing procedure involves participants starting from a static squat position upon hearing the whistle signal, followed by three maximal effort 30-meter sprints, with a 2-minute rest interval between each trial. The shortest time recorded from the three trials is designated as the 30-meter sprint performance. Additionally, the times taken to reach 5 meters and 10 meters during the sprint are recorded, alongside the maximum speed achieved and the time taken to reach that maximum speed.
2.3.3 Counter movement jump.
The Counter Movement Jump (CMJ) is utilized to reflect the explosiveness of the lower limbs. The testing procedure is as follows: participants stand with their hands placed on their hips on the Smartjump vertical jump mat (Smartjump, Fusion Sport, Australia) and perform a rapid squat to a knee flexion of 90 degrees while maintaining an upright posture. Subsequently, they execute a swift jump, during which participants are instructed to keep their torso as vertical as possible to minimize the influence of upper body movement on the test results. In this study, participants are required to complete a series of five consecutive CMJ tests, with the first two serving as warm-ups and the last three as official trials. Each CMJ test is separated by a 15-second recovery interval during which participants remain standing. During the tests, participants are instructed to jump with maximal effort, and the highest jump height from the final three trials is recorded for analysis [24].
2.3.4 Reactive agility test.
The Reactive Agility Test (RAT) is employed to measure the quality of reaction agility, following established methodologies from previous research [25]. The procedure is as follows: participants stand 0.5 meters behind the Smartspeed timing gates (Smartspeed Pro, Fusion Sport, Australia) and, upon hearing the “Go” command, complete the Y-shaped reactive agility test as quickly as possible. This test consists of a 5-meter sprint followed by a 45° change of direction (either left or right) and then another 5-meter sprint. The direction of the change is randomly determined by a triggering device located 2.5 meters away (triggering timing gate). As participants pass through this device, the timing gates at the left and right endpoints are randomly illuminated, requiring participants to react swiftly and sprint through the illuminated timing gate. Each run from the starting point to the endpoint constitutes one test trial, with a total of six trials completed (three to the left and three to the right). A 30-second interval is provided between trials, during which participants jog or walk back to the starting point to prepare for the next test. The shortest sprint time from these trials is recorded for analysis [26,27].
2.3.5 Y-balance test.
The Y-balance Test (YBT) is utilized to evaluate the balance capabilities of participants, following established methodologies from previous research [28]. The testing procedure is as follows: participants stand on the Y-Balance Test apparatus with their hands placed on their hips and one bare foot planted firmly on the platform. They then use the toes of the non-supporting leg to slowly push the testing boards in three directions to their maximal reach. The testing sequence involves first measuring with the right leg as the support leg, followed by the left leg, assessing the maximum distance achieved in the anterior (A), posteromedial (PM), and posterolateral (PL) directions. Each direction is measured three times, and the maximum distance reached in each direction is recorded for analysis. At the conclusion of the test, the comprehensive score for the participant's YBT is calculated based on the distances achieved in the three directions for both legs. The formula for calculating the composite value (%) is as follows:
Composite Value (%)=[(A + PM + PL) / (3×Lower Limb Length)]×100.
This score serves as an assessment of the participant's balance ability.
2.4 Intervention program design
In this intervention plan, the INT group utilized an INT protocol adapted from previous studies [12,15,29]. This protocol incorporated a combination of agility training, speed and coordination training, core strength and balance training, resistance strength training, and plyometric training. The intervention spans 12 weeks, with a training frequency of three sessions per week (Monday, Wednesday, and Friday afternoons), each lasting 45 minutes, totaling 36 intervention sessions. Each intervention session was conducted after a standardized warm-up, which was identical to the warm-up performed before testing [20], and before the specialized Sanda training.
The INT program is structured to adjust and increase the training content, intensity, and volume every three weeks (Appendix S1). During weeks 1, 4, 7, and 10, particular emphasis is placed on the accuracy of individual movements, the active range of motion, and the quality of movement completion. Adjustments and increases adhere to a progressive principle, transitioning from basic bodyweight exercises to those incorporating additional equipment such as medicine balls, from static balance exercises to dynamic balance training, and from single-module balance training to multi-module training that includes reactive and coordination modules. The training load progressively increases over time. This incremental approach to training difficulty, volume, and accumulation emphasizes neural adaptation as well as the development of muscular endurance and strength [30,31].
The training model follows a circuit-style format; for instance, in the initial three weeks, participants complete each module (e.g., strength training) before proceeding to the next module (e.g., plyometric training). Specific training modalities (e.g., 70% 1RM Split Squat) are practiced after completing all prescribed repetitions and sets before transitioning to the next modality (e.g., 70% 1RM Bench Press). Rest intervals of 20–120 seconds are provided between sets and exercises. All participants underwent 1RM testing for squat and bench press before the training sessions [30], and the loading parameters for strength exercises were based on recommendations from prior studies [32,33].
The CON group completed a conventional Sanda conditioning program matched for total training load: 45 min/session, 3 sessions/week for 12 weeks, consisting of (1) 10 min jogging + dynamic stretching; (2) 25 min technical drills (empty‑hand striking, leg kicking, partner target‑hitting); (3) 10 min cool‑down. Volume, total session duration, and weekly frequency were identical to the INT group to ensure equivalent external training load. We also added Appendix S1 with week‑by‑week progression for both INT and CON groups.
2.5 Statistical analyses
Statistical analyses were conducted using SPSS (version 25.0; SPSS Inc., Armonk, NY). The Shapiro-Wilk test was employed to assess the normality of data distribution for each group. For data that violated the normality assumption as indicated by the Shapiro-Wilk test, the Mann-Whitney U test was utilized. Descriptive statistics were presented as mean ± standard deviation (M ± SD). Independent samples t-tests were performed to determine whether significant differences existed in demographic characteristics, baseline features, and relative changes (∆) in test metrics from PRE to POST between the intervention group (INT) and control group (CON). For between group independent t tests/Mann–Whitney U tests, a Bonferroni correction was applied to control Type I error due to multiple dependent variables. For data that did not meet the normality assumption, the Wilcoxon signed-rank test was executed to compare PRE and POST values. Additionally, Cohen’s d effect sizes were reported for paired sample t-tests, with interpretation criteria for d as follows: < 0.2 (small), 0.2–0.6 (medium), 0.6–1.2 (large), 1.2–2.0 (very large), and >2.0 (extremely large) [34]. Significance levels were set at P < 0.05 for statistical significance, P < 0.01 for high significance, and P < 0.001 for very high significance. A post hoc power analysis was conducted using G*Power (version 3.1) based on the primary outcome (countermovement jump, CMJ) with α = 0.05. The achieved power was 0.82, indicating the sample size (n = 13 per group) provided sufficient statistical power to detect the observed between group differences.
3 Results
Although participants were recruited from international, national, and national first‑level competitive categories, randomized 1:1 allocation was applied, and no significant between‑group differences were detected in demographic or baseline performance variables (all p > 0.05), which minimized confounding from heterogeneity. Nevertheless, residual heterogeneity cannot be fully excluded due to the relatively small sample (as shown in Table 1).
No significant differences were observed between the intervention group and the control group in any of the test metrics before the intervention (all p > 0.05), indicating no baseline differences between the groups (as shown in Table 2).
Post-intervention, the INT group showed significant improvements in these physical fitness measures: [1RM bench press (p < 0.001, d = 2.599), 1RM squat (p < 0.001, d = 2.610), T-5m (p = 0.011, d = −1.000), T-10m (p = 0.011, d = −0.833), T-30m (p < 0.001, d = −6.120), CMJ (p < 0.001, d = 4.236), RAT (p < 0.001, d = −3.312), YBT-L (p < 0.001, d = 3.075), YBT-R (p < 0.001, d = 2.722)] (see Table 3). In the CON group, there were no significant changes in physical quality test scores post-intervention. Relative changes from pre- to post-intervention indicated no significant differences in △-T-5m between INT and CON groups, while significant differences were found in other physical quality assessments [△-1RM bench press (3.376 vs 0.220 kg, p < 0.001), △-1RM squat (3.665 vs −0.533 kg, p < 0.001), △-T-10m (−0.005 vs 0.005 s, p = 0.004), △-T-30m (−0.153 vs −0.017 s, p < 0.001), △-CMJ (4.846 vs 0.615 cm, p < 0.001), △-RAT (−0.048 vs −0.002 s, p < 0.001), △-YBT-L (5.154 vs −0.615, p < 0.001), △-YBT-R (5.615 vs −0.308, p < 0.001)] (see Table 4).
4 Discussion
The results of this study suggest that a 12-week Integrative Neuromuscular Training (INT) program has a beneficial impact on the overall performance of martial arts Sanda athletes. Specifically, participants in the INT group showed improvements in strength, speed, jumping ability, reaction time, and balance. Furthermore, INT appears to be a safe training intervention, as no injuries were reported during implementation, despite the gradual increases in training intensity, volume, and duration.
In this study, the INT training program demonstrated a significant positive effect on the strength (1RM), movement speed, and vertical jump height of Sanda athletes. These findings align with previous INT research, which has shown significant improvements in 1RM following various INT interventions, whether conducted twice, three times, or four times a week over an 8-week period [15,19,35]. Notably, after 8 weeks of INT training twice a week, the time for a 10-meter sprint was significantly reduced [35,36]. Additionally, a 19.1 ± 4.2 cm increase in Countermovement Jump (CMJ) was observed (19.1 ± 4.2 vs. 20.3 ± 4.04 cm, d = 0.3) after 8 weeks of INT training [15]. Furthermore, after 6 weeks of INT training, vertical jump height increased from 39.9 ± 0.9 cm to 43.2 ± 1.1 cm [37]. Improvements in sprint speed and reaction time during rapid changes of direction were also noted after 6 weeks of INT training conducted twice a week [38]. Finally, following 12 weeks of INT training, significant improvements were observed in single-leg balance (OR=2.8; 95% CI 1.1 to 4.6) and the Star Excursion Balance Test (SEBT) (OR=4.7; 95% CI 2.2 to 7.1) [39].
Previous research has reported a strong correlation between leg extensor strength and sprint performance, indicating that increases in lower limb muscle strength can enhance short-duration sprint capabilities [40]. Integrative Neuromuscular Training (INT) typically enhances vertical jump performance by improving leg muscle strength [41,42]. Furthermore, vertical jump height has been shown to be significantly associated with sprinting ability [43,44]. Enhancements in sprint performance and muscle strength can also lead to improvements in agility, particularly in change of direction (CoD) performance [45]. Additionally, a significant correlation exists between eccentric strength and dynamic balance, with moderate correlations observed between the ability to generate power and dynamic balance [46]. These findings further corroborate the positive improvements in strength, speed, vertical jump height, and agility observed in this study.
The observed positive improvements in strength, speed, vertical jump height, agility, and balance can be attributed to various factors inherent in the training content selected for this study. The INT program integrates diverse modalities of strength, speed, power, agility, core strengthening, balance, resistance training, and plyometric training. This comprehensive approach combines basic and specific movements, featuring both repetitive training of individual technical skills and multifaceted training of various athletic qualities. The enhancement in physical fitness among participants likely results from the strategic combination of different technical movements and the synergistic effects of the diverse training interventions employed.
For instance, numerous studies and meta-analyses have demonstrated the positive impact of plyometric training—incorporated within our INT programming strength, speed (e.g., Countermovement Jump), and reactive performance. Research comparing 12 weeks of enhanced training, resistance training, and a combination of both found that the combined training approach significantly outperformed single-method training regarding improvements in athletes’ leg strength [47]. Our INT program effectively integrates extensive content from both strength training and plyometric training, encompassing both full-body exercises (e.g., squats) and specific lower limb muscle training (e.g., prone leg curls with machines).
Moreover, the plyometric jump training included in the INT program comprises various jump exercise variations, all aimed at enhancing athletes’ lower limb strength and power [48]. Miller et al. observed significant improvements in performance on the Illinois agility test in athletes following 6 weeks of plyometric training [49]. Participants exhibited small to moderate improvements (Effect Size [ES] = 0.35–0.80, all p < 0.05) in most outcomes, including maximal dynamic strength, linear sprint speed, horizontal jump distance, and reactive strength index, after engaging in plyometric jump training [50]. A systematic review with meta-analysis focused on combat athletes indicated that plyometric-jump training programs, spanning 4–12 weeks and comprising 2–3 sessions per week, yielded small to moderate improvements (ES = 0.47 to 1.04) in maximal strength (e.g., 1RM squat), vertical jump height, and change-of-direction speed when compared to control groups [51]. MYER et al. concluded that enhanced training and dynamic balance exercises significantly improve biomechanical and neuromuscular performance, as well as balance ability [52].
Additionally, a study involving football players demonstrated that forward lunge training—conducted twice a week for 6 weeks—resulted in significant improvements in both hamstring strength and sprint performance for participants in both the walking forward lunge and jumping forward lunge groups [53]. Another study showed that in-line lunge movements correlate positively with agility performance [54], which aligns with the inclusion of similar lunge training elements in our INT program.
According to Sheppard and Young [55], agility is defined as a rapid whole-body movement that involves a change in velocity or direction in response to a stimulus. As such, agility encompasses both a change of direction (CoD) component [56] and a perceptual decision-making component. The agility training integrated into this INT program, including exercises such as Rapid Dodge and Counterattack Training, likely enhanced the cognitively determined abilities of the Sanda athletes. This training may have facilitated greater motor unit recruitment and synchronization, as well as an increased rate of coding [57], ultimately fostering an adequate neuromuscular response.
Numerous factors influence the maintenance of balance, including the eccentric strength of the knee extensors, lower limb explosive strength, core stability, and the range of motion in lower limb joints [46,58]. To address these factors, our INT program incorporates training components designed to enhance eccentric explosive strength of the knee extensors, such as plyometric jumps and forward lunges. Additionally, it includes core strength training exercises, such as Russian twists with a medicine ball and side bridges, which are aimed at increasing the strength of the abdominal and spinal muscles, thereby improving core stability. Furthermore, lower limb strength training is crucial for enhancing hamstring strength, which is vital for the stability of the knee joint [59].
Furthermore, the gains in explosive strength, speed, and balance may be attributed to neuromuscular adaptations, such as more effective motor unit recruitment, rate coding (the frequency of action potentials), synchronization, and intermuscular coordination [60,61]. Research has demonstrated that INT training enhances the synchronization and coordination of muscle activity patterns in athletes, thereby improving dynamic joint stability and fine motor control, which in turn enhances movement efficiency [62,63]. Speed improvements may be linked to increased neuromuscular activation, specifically the upregulation of motor unit discharge frequency, as well as improvements in ground contact time and the stiffness of muscle-tendon units [36,64].
More specifically, the increase in the number of active motor units or their firing frequency, along with changes in the recruitment patterns of motor units (primarily fast-twitch fibers), may contribute to enhanced speed [65]. These factors could accelerate the development of explosive strength [66], maximize force production [67], and improve the efficiency of the stretch-shortening cycle [68], potentially enhancing sprinting performance through changes in stride length and frequency [69].
Some studies suggest that balance training improves postural stability by diminishing the potential for Ia afferent nerve activity to exert inhibitory effects through intermediate inhibitory neurons; this spinal cord response inhibition may help improve post-training balance performance [70]. Additionally, our INT program includes multidirectional movements (e.g., simulating agility T-tests and lateral rope ladder training), which may enhance adaptability in both the peripheral and central nervous systems, thereby increasing proprioceptive awareness in the lower limbs [71]. Consequently, the combined effects of training for core strength, lower limb explosive power, and proprioception manifest as improved Y-balance scores.
Additionally, the training content within this INT program shares similarities with the testing components that follow. The researchers believe this aligns with the principle of training specificity, which posits that when the characteristics of training (such as exercise type, contraction pattern, and movement speed) are consistent with the activities being tested, the adaptations related to training are likely to be more pronounced [72].
The muscle strength and explosiveness of both the upper and lower limbs are crucial for Sanda athletes, as most technical movements in combat sports originate from the lower body. Compared to the upper limbs, the significance of lower limb strength and power is particularly pronounced [73]. Research has indicated that the correlations between strength/power variables and punching impact indices range from 0.67 to 0.85, highlighting strong associations between punching impact and strength/power variables, especially lower limb muscle power [7]. Additionally, studies have found that 1RM squat strength can serve as an important indicator for distinguishing the neuromuscular qualities of higher and lower-level mixed martial arts competitors [74]. This view is supported by Lachlan P. James, who asserts that neuromuscular strength and anaerobic capacity can differentiate high-level from low-level combat athletes, noting that those with better lower limb strength and explosiveness are likely to execute technical movements more effectively, thereby enhancing athletic performance [75]. In Sanda competitions, the fighting area measures 8 meters by 8 meters, making movement speed equally vital for athletes. In particular, the ability to move quickly within a 5-meter radius is essential, as athletes need to swiftly position themselves in front of their opponents to deliver effective strikes, evade attacks, and prepare for subsequent offensive actions.
The INT training program in this study is beneficial for improving the neuromuscular adaptability and excitability of motor neurons in Sanda athletes. The Hoffman (H) reflex can be utilized to assess the excitability of spinal α-motoneurons while also reflecting transmission efficiency, particularly presynaptic inhibition in Ia afferent synapses [76]. The H-reflex is best interpreted as an estimate of “net spinal excitability,” which encompasses the summation of both excitatory and inhibitory descending and afferent synaptic inputs, presynaptic inhibition, and the intrinsic properties of motor neurons [77]. Pre-reaction time refers to the duration taken to identify external stimulus signals and respond appropriately before entering the execution phase [78]. Research has demonstrated that after 14 weeks of resistance training, an increase in maximum muscle strength during contractions is accompanied by an enhancement in the H-reflex response [76]. This may indicate that INT training improves the excitability of α-motoneurons in Sanda athletes, enabling them to process stimulus signals more rapidly in the brain. Consequently, commands are transmitted via efferent neurons to effectors, stimulating the corresponding muscles to contract and generate movement [79].
This improvement may also be a result of neuromuscular adaptation to external signals, which is crucial for athletes during competition. In high-intensity matches, athletes must quickly assess the status of their opponents to seize opportunities for precise attacks. During defensive maneuvers, observing the opponent's attacking patterns allows athletes to anticipate and evade or block incoming strikes, enabling them to respond with counterattacks effectively.
4.1 Limitations of the study
A limitation of the present study is that the participants were drawn from different competitive levels, which may have introduced some heterogeneity in baseline training background and responsiveness to the intervention. Although no significant between-group differences were observed at baseline, the relatively small sample size means that the potential influence of this heterogeneity cannot be fully excluded. In addition, the current study did not evaluate whether the INT intervention could be utilized for injury prevention or whether its benefits could translate into improved long-term health outcomes for athletes. Future research should specifically address these objectives through longitudinal studies. Furthermore, genetic variability may partly contribute to inter-individual differences in training responsiveness and performance adaptation. Future studies may therefore incorporate candidate genetic markers [80] or polygenic approaches to better understand whether adaptations to INT differ across athletes with different genetic profiles [81].
5 Conclusion
The 12-week INT intervention significantly improved the physical performance of the athletes. The enhancements observed in the INT group across measures such as 1RM, sprinting speed, Counter Movement Jump (CMJ), reaction agility, and Y balance tests demonstrate the feasibility of INT as a comprehensive training approach for elite Sanda athletes. Furthermore, INT may be incorporated as a regular conditioning strategy before formal training sessions to enhance selected aspects of physical performance in elite Sanda athletes.
5.1 Practical applications
Compared to traditional training methods, the INT training program places a stronger emphasis on developing agility, speed, neuromuscular coordination, proprioceptive control, stability, and lower limb explosiveness. Research has shown that the comprehensive improvements in physical qualities following the training support this emphasis [15,35]. This study structured the loading patterns according to the development principles of different physical qualities, employing lower loads for reaction, agility, and speed training while utilizing higher loads for resistance and plyometric training. The focus was on enhancing the athletes’ reaction agility, speed coordination, balance stability, and explosiveness. The experimental results confirm that the 12-week INT training program effectively achieved the expected goals of comprehensive physical improvement in elite Sanda athletes. This outcome indicates that, despite the participants’ already high physical quality levels, our designed INT training plan successfully enhanced their physical capabilities. It suggests to coaches and elite Sanda athletes that INT may have a positive impact on selected physical attributes, even in high-level competitors.
References
- 1. Dai GB, Lu A. Wushu: a culture of adversaries. J Phil Sport. 2019;46(3):321–38.
- 2. Jiang X. High-intensity physical training for chinese boxing athletes. Rev Bras Med Esporte. 2023;29.
- 3. Dhahbi W, Ben Saad H, Dergaa I, Souaifi M, Chamari K. Injury Profiling in Male Police Cadets During Initial Training Phase: A Retrospective Cohort Study. Am J Mens Health. 2024;18(6):15579883241304584. pmid:39651577
- 4. Russo G, Ottoboni G. The perceptual – Cognitive skills of combat sports athletes: A systematic review. Psychol Sport Exerc. 2019;44:60–78.
- 5. Lei Z, Lv W. Feature Extraction-Based Fitness Characteristics and Kinesiology of Wushu Sanda Athletes in University Analysis. Math Probl Eng. 2022;2022.
- 6. Dhahbi W. Editorial: Advancing biomechanics: enhancing sports performance, mitigating injury risks, and optimizing athlete rehabilitation. Front Sports Act Living. 2025;7:1556024. pmid:39968189
- 7. Loturco I, Nakamura FY, Artioli GG, Kobal R, Kitamura K, Cal Abad CC, et al. Strength and Power Qualities Are Highly Associated With Punching Impact in Elite Amateur Boxers. J Strength Cond Res. 2016;30(1):109–16. pmid:26110348
- 8. Durand-Bush N, Salmela JH. The Development and Maintenance of Expert Athletic Performance: Perceptions of World and Olympic Champions. J Appl Sport Psychol. 2002;14(3):154–71.
- 9. Smith DJ. A framework for understanding the training process leading to elite performance. Sports Med. 2003;33(15):1103–26. pmid:14719980
- 10. Zazulak BT, Hewett TE, Reeves NP, Goldberg B, Cholewicki J. Deficits in neuromuscular control of the trunk predict knee injury risk: a prospective biomechanical-epidemiologic study. Am J Sports Med. 2007;35(7):1123–30. pmid:17468378
- 11. Emery CA, Roy T-O, Whittaker JL, Nettel-Aguirre A, van Mechelen W. Neuromuscular training injury prevention strategies in youth sport: a systematic review and meta-analysis. Br J Sports Med. 2015;49(13):865–70. pmid:26084526
- 12. Fort-Vanmeerhaeghe A, Romero-Rodriguez D, Lloyd RS, Kushner A, Myer GD. Integrative Neuromuscular Training in Youth Athletes. Part II: Strategies to Prevent Injuries and Improve Performance. Strength Cond J. 2016;38(4):9–27.
- 13. Faigenbaum AD, Myer GD. Resistance training among young athletes: safety, efficacy and injury prevention effects. Br J Sports Med. 2010;44(1):56–63. pmid:19945973
- 14. Kushner AM, Kiefer AW, Lesnick S, Faigenbaum AD, Kashikar-Zuck S, Myer GD. Training the developing brain part II: cognitive considerations for youth instruction and feedback. Curr Sports Med Rep. 2015;14(3):235–43. pmid:25968858
- 15. Panagoulis C, Chatzinikolaou A, Avloniti A, Leontsini D, Deli CK, Draganidis D, et al. In-Season Integrative Neuromuscular Strength Training Improves Performance of Early-Adolescent Soccer Athletes. J Strength Cond Res. 2020;34(2):516–26. pmid:30431535
- 16. McLeod TCV, Armstrong T, Miller M, Sauers JL. Balance improvements in female high school basketball players after a 6-week neuromuscular-training program. J Sport Rehabil. 2009;18(4):465–81. pmid:20108849
- 17. Sugimoto D, Myer GD, Bush HM, Hewett TE. Effects of compliance on trunk and hip integrative neuromuscular training on hip abductor strength in female athletes. J Strength Cond Res. 2014;28(5):1187–94. pmid:24751656
- 18. Pasanen K, Parkkari J, Pasanen M, Kannus P. Effect of a neuromuscular warm-up programme on muscle power, balance, speed and agility: a randomised controlled study. Br J Sports Med. 2009;43(13):1073–8. pmid:19622526
- 19. Xiong J, Li S, Cao A, Qian L, Peng B, Xiao D. Effects of integrative neuromuscular training intervention on physical performance in elite female table tennis players: A randomized controlled trial. PLoS One. 2022;17(1):e0262775. pmid:35051233
- 20. Harrison AJ, Bourke G. The effect of resisted sprint training on speed and strength performance in male rugby players. J Strength Cond Res. 2009;23(1):275–83. pmid:19125101
- 21. Hong Y, Liu R, Chen XP. Research on electromyographic characteristics of deep squatting with and without weight under stable and multilevel unstable conditions based on electromyography root mean square and envelope. J Sports Sci. 2016;36(03):67–73.
- 22. Dhahbi W, Padulo J, Russo L, Racil G, Ltifi M-A, Picerno P, et al. 4-6 Repetition Maximum (RM) and 1-RM Prediction in Free-Weight Bench Press and Smith Machine Squat Based on Body Mass in Male Athletes. J Strength Cond Res. 2024;38(8):1366–71. pmid:38888595
- 23. Harrison AJ, Jensen RL, Donoghue O. A Comparison of Laser and Video Techniques for Determining Displacement and Velocity During Running. Meas Phys Educ Exerc Sci. 2005;9(4):219–31.
- 24. Lombard W, Reid S, Pearson K, Lambert M. Reliability of metrics associated with a counter-movement jump performed on a force plate. Meas Phys Educ Exerc Sci. 2017;21(4):235–43.
- 25. Fiorilli G, Iuliano E, Mitrotasios M, Pistone EM, Aquino G, Calcagno G, et al. Are Change of Direction Speed and Reactive Agility Useful for Determining the Optimal Field Position for Young Soccer Players? J Sports Sci Med. 2017;16(2):247–53. pmid:28630578
- 26. Yuan H, Mao J, Lai C, Lu H, Xue Y, Liu Q. Acute effects of foam rolling and dynamic stretching on angle-specific change of direction ability, flexibility and reactive strength in male basketball players. Biol Sport. 2023;40(3):877–87. pmid:37398972
- 27. Li L, Mei T. Partial sleep deprivation affects the athletic performance of Sanda athletes: An RCT study. Heliyon. 2024;10(19):e38879. pmid:39421376
- 28. Plisky PJ, Gorman PP, Butler RJ, Kiesel KB, Underwood FB, Elkins B. The reliability of an instrumented device for measuring components of the star excursion balance test. N Am J Sports Phys Ther. 2009;4(2):92–9. pmid:21509114
- 29. Vitale JA, La Torre A, Banfi G, Bonato M. Effects of an 8-Week Body-Weight Neuromuscular Training on Dynamic Balance and Vertical Jump Performances in Elite Junior Skiing Athletes: A Randomized Controlled Trial. J Strength Cond Res. 2018;32(4):911–20. pmid:29401197
- 30. Faigenbaum AD, Kraemer WJ, Blimkie CJR, Jeffreys I, Micheli LJ, Nitka M, et al. Youth resistance training: updated position statement paper from the national strength and conditioning association. J Strength Cond Res. 2009;23(5 Suppl):S60-79. pmid:19620931
- 31. Ralston GW, Kilgore L, Wyatt FB, Baker JS. The Effect of Weekly Set Volume on Strength Gain: A Meta-Analysis. Sports Med. 2017;47(12):2585–601. pmid:28755103
- 32. Izquierdo M, Häkkinen K, Gonzalez-Badillo JJ, Ibáñez J, Gorostiaga EM. Effects of long-term training specificity on maximal strength and power of the upper and lower extremities in athletes from different sports. Eur J Appl Physiol. 2002;87(3):264–71. pmid:12111288
- 33. Mayhew JL, Johnson BD, Lamonte MJ, Lauber D, Kemmler W. Accuracy of prediction equations for determining one repetition maximum bench press in women before and after resistance training. J Strength Cond Res. 2008;22(5):1570–7. pmid:18714230
- 34. Saddoud A, Rekik G, Belkhir Y, Kammoun N, Hidouri S, Chlif M, et al. One night of total sleep deprivation impairs decision-making skills, anaerobic performances, mood states, and perceptual responses in elite Kung-Fu athletes. Biol Rhythm Res. 2023;54(1):102–16.
- 35. Hammami R, Negra Y, Nebigh A, Ramirez-Campillo R, Moran J, Chaabene H. Preseason Integrative Neuromuscular Training Improves Selected Measures of Physical Fitness in Highly Trained, Youth, Male Soccer Players. J Strength Cond Res. 2023;37(6):e384–90. pmid:37235541
- 36. Rimmer E, Sleivert G. Effects of a Plyometrics Intervention Program on Sprint Performance. J Strength Cond Res. 2000;14(3):295–301.
- 37. Myer GD, Ford KR, Palumbo JP, Hewett TE. Neuromuscular training improves performance and lower-extremity biomechanics in female athletes. J Strength Cond Res. 2005;19(1):51–60. pmid:15705045
- 38. Arede J, Fernandes J, Moran J. Effects of an integrative neuromuscular training protocol vs. FIFA 11 on sprint, change of direction performance and inter-limb asymmetries in young soccer players. Int J Sports Sci Coach. 2022;17(1):54–62.
- 39. Steffen K, Emery CA, Romiti M, Kang J, Bizzini M, Dvorak J, et al. High adherence to a neuromuscular injury prevention programme (FIFA 11+) improves functional balance and reduces injury risk in Canadian youth female football players: a cluster randomised trial. Br J Sports Med. 2013;47(12):794–802. pmid:23559666
- 40. McBride JM, Blow D, Kirby TJ, Haines TL, Dayne AM, Triplett NT. Relationship between maximal squat strength and five, ten, and forty yard sprint times. J Strength Cond Res. 2009;23(6):1633–6. pmid:19675504
- 41. Hilfiker R, Hübner K, Lorenz T, Marti B. Effects of drop jumps added to the warm-up of elite sport athletes with a high capacity for explosive force development. J Strength Cond Res. 2007;21(2):550–5. pmid:17530974
- 42. Lesinski M, Prieske O, Granacher U. Effects and dose-response relationships of resistance training on physical performance in youth athletes: a systematic review and meta-analysis. Br J Sports Med. 2016;50(13):781–95. pmid:26851290
- 43. Rodríguez-Rosell D, Mora-Custodio R, Franco-Márquez F, Yáñez-García JM, González-Badillo JJ. Traditional vs. Sport-Specific Vertical Jump Tests: Reliability, Validity, and Relationship With the Legs Strength and Sprint Performance in Adult and Teen Soccer and Basketball Players. J Strength Cond Res. 2017;31(1):196–206. pmid:27172267
- 44. Meylan C, McMaster T, Cronin J, Mohammad NI, Rogers C, Deklerk M. Single-leg lateral, horizontal, and vertical jump assessment: reliability, interrelationships, and ability to predict sprint and change-of-direction performance. J Strength Cond Res. 2009;23(4):1140–7. pmid:19528866
- 45. Jones PA, Bampouras T, Marrin K. An investigation into the physical determinants of change of direction speed. J Sports Med Phys Fitness. 2009;49(1):97–104.
- 46. Booysen MJ, Gradidge PJ-L, Watson E. The relationships of eccentric strength and power with dynamic balance in male footballers. J Sports Sci. 2015;33(20):2157–65. pmid:26153432
- 47. Fatouros IG, Jamurtas AZ, Leontsini D, Taxildaris K, Aggelousis N, Kostopoulos N, et al. Evaluation of Plyometric Exercise Training, Weight Training, and Their Combination on Vertical Jumping Performance and Leg Strength. J Strength Cond Res. 2000;14(4):470–6.
- 48. Thomas K, French D, Hayes PR. The effect of two plyometric training techniques on muscular power and agility in youth soccer players. J Strength Cond Res. 2009;23(1):332–5. pmid:19002073
- 49. Miller MG, Herniman JJ, Ricard MD, Cheatham CC, Michael TJ. The effects of a 6-week plyometric training program on agility. J Sports Sci Med. 2006;5(3):459–65. pmid:24353464
- 50. Ramirez-Campillo R, Sortwell A, Moran J, Afonso J, Clemente FM, Lloyd RS, et al. Plyometric-Jump Training Effects on Physical Fitness and Sport-Specific Performance According to Maturity: A Systematic Review with Meta-analysis. Sports Med Open. 2023;9(1):23. pmid:37036542
- 51. Ojeda-Aravena A, Herrera-Valenzuela T, Valdés-Badilla P, Báez-San Martín E, Thapa RK, Ramirez-Campillo R. A Systematic Review with Meta-Analysis on the Effects of Plyometric-Jump Training on the Physical Fitness of Combat Sport Athletes. Sports (Basel). 2023;11(2):33. pmid:36828318
- 52. Myer GD, Ford KR, Brent JL, Hewett TE. The effects of plyometric vs. dynamic stabilization and balance training on power, balance, and landing force in female athletes. J Strength Cond Res. 2006;20(2):345–53. pmid:16686562
- 53. Jönhagen S, Ackermann P, Saartok T. Forward lunge: a training study of eccentric exercises of the lower limbs. J Strength Cond Res. 2009;23(3):972–8. pmid:19387378
- 54. Paul DJ, Gabbett TJ, Nassis GP. Agility in Team Sports: Testing, Training and Factors Affecting Performance. Sports Med. 2016;46(3):421–42. pmid:26670456
- 55. Sheppard JM, Young WB. Agility literature review: classifications, training and testing. J Sports Sci. 2006;24(9):919–32. pmid:16882626
- 56. Chaabene H, Prieske O, Negra Y, Granacher U. Change of Direction Speed: Toward a Strength Training Approach with Accentuated Eccentric Muscle Actions. Sports Med. 2018;48(8):1773–9. pmid:29594958
- 57.
Komi PV. Stretch‐Shortening Cycle. Strength and Power in Sport. Wiley; 2003. p. 184–202.
- 58. López-Valenciano A, Ayala F, De Ste Croix M, Barbado D, Vera-Garcia FJ. Different neuromuscular parameters influence dynamic balance in male and female football players. Knee Surg Sports Traumatol Arthrosc. 2019;27(3):962–70. pmid:30088029
- 59. Hiemstra LA, Webber S, MacDonald PB, Kriellaars DJ. Hamstring and quadriceps strength balance in normal and hamstring anterior cruciate ligament-reconstructed subjects. Clin J Sport Med. 2004;14(5):274–80. pmid:15377966
- 60. Legerlotz K, Marzilger R, Bohm S, Arampatzis A. Physiological Adaptations following Resistance Training in Youth Athletes-A Narrative Review. Pediatr Exerc Sci. 2016;28(4):501–20. pmid:27705536
- 61. Gabriel DA, Kamen G, Frost G. Neural adaptations to resistive exercise: mechanisms and recommendations for training practices. Sports Med. 2006;36(2):133–49. pmid:16464122
- 62. Guido JA Jr, Stemm J. Reactive Neuromuscular Training: A Multi-level Approach to Rehabilitation of the Unstable Shoulder. N Am J Sports Phys Ther. 2007;2(2):97–103. pmid:21522207
- 63. Myers JB, Lephart SM. The role of the sensorimotor system in the athletic shoulder. J Athl Train. 2000;35(3):351–63. pmid:16558648
- 64. Mero A, Jaakkola L, Komi PV. Relationships between muscle fibre characteristics and physical performance capacity in trained athletic boys. J Sports Sci. 1991;9(2):161–71. pmid:1895353
- 65. Hakkinen K. Effect of explosive type strength training on electromyographic and force production characteristics of les extensor muscles during concentric and various stretch-shortening cycle exercises. Scand J Sports Sci. 1985;7:65–76.
- 66. Rodríguez-Rosell D, Pareja-Blanco F, Aagaard P, González-Badillo JJ. Physiological and methodological aspects of rate of force development assessment in human skeletal muscle. Clin Physiol Funct Imaging. 2018;38(5):743–62. pmid:29266685
- 67. Taber C, Bellon C, Abbott H, Bingham GE. Roles of Maximal Strength and Rate of Force Development in Maximizing Muscular Power. Strength Cond J. 2016;38(1):71–8.
- 68. Taube W, Leukel C, Gollhofer A. How neurons make us jump: the neural control of stretch-shortening cycle movements. Exerc Sport Sci Rev. 2012;40(2):106–15. pmid:22089697
- 69. Haugen T, Seiler S, Sandbakk Ø, Tønnessen E. The Training and Development of Elite Sprint Performance: an Integration of Scientific and Best Practice Literature. Sports Med Open. 2019;5(1):44. pmid:31754845
- 70. Taube W, Gruber M, Beck S, Faist M, Gollhofer A, Schubert M. Cortical and spinal adaptations induced by balance training: correlation between stance stability and corticospinal activation. Acta Physiol (Oxf). 2007;189(4):347–58. pmid:17263693
- 71. Clark FJ, Burgess PR. Slowly adapting receptors in cat knee joint: can they signal joint angle? J Neurophysiol. 1975;38(6):1448–63. pmid:1221082
- 72. Behm DG. Neuromuscular Implications and Applications of Resistance Training. J Strength Cond Res. 1995;9(4):264–74.
- 73. Dunn EC, Humberstone CE, Franchini E, Iredale KF, Blazevich AJ. Relationships Between Punch Impact Force and Upper- and Lower-Body Muscular Strength and Power in Highly Trained Amateur Boxers. J Strength Cond Res. 2022;36(4):1019–25. pmid:32218063
- 74. James LP, Beckman EM, Kelly VG, Haff GG. The Neuromuscular Qualities of Higher- and Lower-Level Mixed-Martial-Arts Competitors. Int J Sports Physiol Perform. 2017;12(5):612–20. pmid:27632577
- 75. James LP, Haff GG, Kelly VG, Beckman EM. Towards a Determination of the Physiological Characteristics Distinguishing Successful Mixed Martial Arts Athletes: A Systematic Review of Combat Sport Literature. Sports Med. 2016;46(10):1525–51. pmid:26993133
- 76. Aagaard P, Simonsen EB, Andersen JL, Magnusson P, Dyhre-Poulsen P. Neural adaptation to resistance training: changes in evoked V-wave and H-reflex responses. J Appl Physiol. 2002;92(6):2309–18. pmid:12015341
- 77. Funase K, Imanaka K, Nishihira Y. Excitability of the soleus motoneuron pool revealed by the developmental slope of the H-reflex as reflex gain. Electromyogr Clin Neurophysiol. 1994;34(8):477–89.
- 78. Ridderinkhof KR, van den Wildenberg WPM, Segalowitz SJ, Carter CS. Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning. Brain Cogn. 2004;56(2):129–40. pmid:15518930
- 79. Gardiner P, Dai Y, Heckman CJ. Effects of exercise training on alpha-motoneurons. J Appl Physiol (1985). 2006;101(4):1228–36. pmid:16778002
- 80. Bulgay C, Zorba E, Kazan HH, Bayraktar I, Uca M, Ergün MA, et al. BDNF coexpresses with MTOR and is associated with muscle fiber size, lean mass and power-related traits. Eur J Appl Physiol. 2025;125(10):2781–92. pmid:40299026
- 81. Çığırtaş R, Bulgay C, Kazan HH, Akman O, Sporiš G, John G, et al. The ARK2N (C18ORF25) Genetic Variant Is Associated with Muscle Fiber Size and Strength Athlete Status. Metabolites. 2024;14(12):684. pmid:39728465