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Open Access

Retraction

Retraction: Tramadol-induced hepato- and nephrotoxicity in rats: Role of Curcumin and Gallic acid as antioxidants

  • The PLOS One Editors

Following the publication of this article [1], concerns were raised about the results presented in Figs 1 and 2. Specifically,

  • The following panels appear to partially or fully overlap, despite being used to represent different experimental conditions or samples obtained from different animal species, calling into question the reliability of the associated quantified results:
  • All β-actin panels in Fig 1 of this article [1], all β-actin panels in Figs 1 of [2] and [3, retracted in 4], and all β-actin panels in Figs 2 and 3 of [5, retracted in 6].
  • Fig 2C and Fig 2I.

The authors did not respond to editorial requests for comment or to provide the underlying data.

In light of these concerns, which call into question the integrity and reliability of the published results, the PLOS One Editors retract this article.

SAS did not agree with the retraction. AAA and SGEB either did not respond directly or could not be reached.

References

  1. 1. Sheweita SA, Almasmari AA, El-Banna SG. RETRACTED: Tramadol-induced hepato- and nephrotoxicity in rats: Role of Curcumin and Gallic acid as antioxidants. PLoS One. 2018;13(8):e0202110. pmid:30110401
  2. 2. Sheweita SA, Wally M, Hassan M. Erectile Dysfunction Drugs Changed the Protein Expressions and Activities of Drug-Metabolising Enzymes in the Liver of Male Rats. Oxid Med Cell Longev. 2016;2016:4970906. pmid:27800121
  3. 3. Sheweita SA, Meftah AA, Sheweita MS, Balbaa ME. RETRACTED: Erectile dysfunction drugs altered the activities of antioxidant enzymes, oxidative stress and the protein expressions of some cytochrome P450 isozymes involved in the steroidogenesis of steroid hormones. PLoS One. 2020;15(11):e0241509. pmid:33166302
  4. 4. The PLOS One Editors. Retraction: Erectile dysfunction drugs altered the activities of antioxidant enzymes, oxidative stress and the protein expressions of some cytochrome P450 isozymes involved in the steroidogenesis of steroid hormones. PLoS One. 2026;21(4): e0347086.
  5. 5. Sheweita SA, El-Hosseiny LS, Nashashibi MA. RETRACTED: Protective Effects of Essential Oils as Natural Antioxidants against Hepatotoxicity Induced by Cyclophosphamide in Mice. PLoS One. 2016;11(11):e0165667. pmid:27802299
  6. 6. The PLOS One Editors. Retraction: Protective effects of essential oils as natural antioxidants against hepatotoxicity induced by cyclophosphamide in mice. PLoS One. 2026;21(3):e0344547.

Citation: The PLOS One Editors (2026) Retraction: Tramadol-induced hepato- and nephrotoxicity in rats: Role of Curcumin and Gallic acid as antioxidants. PLoS One 21(4): e0347088. https://doi.org/10.1371/journal.pone.0347088

Published: April 13, 2026

Copyright: © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.