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Prevalence and associated risk factors of tinnitus among Palestinian adolescents aged 15–18: A cross-sectional study

  • Saad Al-Lahhaam ,

    Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Writing – original draft

    saedallahham@gmail.com (SAL); m.alqub@najah.edu (MA)

    Affiliation Department of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Raghad Dweikat,

    Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Tala Nazzal,

    Roles Formal analysis, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Aman Maraqa,

    Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Joud Khalil,

    Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Tala Albadawi,

    Roles Conceptualization, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Raghad Doufish,

    Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Wa'd Amer,

    Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Mustafa Ghanim,

    Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Mohammad Abuawad,

    Roles Conceptualization, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Amer Ghrouz,

    Roles Formal analysis, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Samar Alkhaldi,

    Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Laith El-lahham,

    Roles Validation, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Faculty of Medicine, Al-Quds University, Jerusalem, Palestine

  • Majdi Dwikat,

    Roles Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Allied and Applied Medical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  • Maha Rabayaa,

    Roles Conceptualization, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

    Affiliation Department of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

  •  [ ... ],
  • Malik Alqub

    Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

    saedallahham@gmail.com (SAL); m.alqub@najah.edu (MA)

    Affiliation Department of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine

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Abstract

Background

Tinnitus is a prevalent condition worldwide, particularly among adolescents, that has a substantial impact on quality of life, yet it remains an understudied issue.

Objectives

This study aims to determine the prevalence of tinnitus and its associated risk factors among Palestinian adolescents aged 15–18.

Methods

A cross-sectional study was conducted from January to March 2025. A convenience sample of participants was recruited. The study utilized the European School for the Interdisciplinary Tinnitus Research Screening Questionnaire.

Results

A total of 1,131 participants were enrolled in the study, with 64.5% being females. The prevalence of tinnitus among the study sample was 532, representing 47% of the population. Females had a higher prevalence of tinnitus, with 370 affected (50.7%) compared to males (40.4%). Significant associations were found between tinnitus and several factors: age, positive family history of tinnitus (threefold increased risk), sensitivity to external sounds (2.7 times higher likelihood), slight hearing difficulty in noisy environments (1.7 times higher risk), pain symptoms (double the risk), and difficulty falling asleep (1.8 times higher risk). Notably, the majority of affected participants (71.5%) had never sought professional care for their tinnitus.

Conclusion

Although Tinnitus is common among Palestinian adolescents aged 15–18 years, the majority of affected participants did not seek professional care for tinnitus. These findings highlight the importance of conducting further research to shed insight into this prevalent and neglected health priority.

Introduction

Tinnitus is described as the perception of sound in the absence of external auditory stimuli. Commonly, individuals with tinnitus report hearing sounds such as hissing, sizzling, or ringing. More complex auditory experiences, such as voices or music, have also been documented in some patients [1]. Tinnitus that coincides with the heartbeat may suggest a vascular origin [2,3]. When it does not, palatal muscles or myoclonus of the middle ear is more likely to be the cause, while a lack of such synchronization often points to other causes, such as palatal muscle spasms or myoclonus of the middle ear [2]. Tinnitus typically develops gradually, although it can sometimes have a rapid onset [4]. Many patients report that stress can exacerbate their symptoms, highlighting the potential influence of emotional and psychological factors in the experience of tinnitus [5].

Despite extensive research, the mechanisms behind tinnitus remain poorly understood. It is believed to arise from complex interactions between the auditory pathways, the central nervous system, and other systems. Several factors have been identified as potential risk factors for the development of tinnitus. These include otological (hearing-related), neurological, psychiatric, cardiovascular, traumatic, rheumatological, immune-mediated, endocrine, and metabolic factors. Lifestyle factors such as previous head injuries, alcohol consumption, arthritis, obesity, smoking, and hypertension have also been identified as contributing to the risk of tinnitus [69]. The challenges in tinnitus research stem from its multifactorial etiology, the diverse comorbidities associated with it, its wide clinical variability, and the subjective nature of its assessment [10,11].

Tinnitus is a widespread condition, affecting a significant proportion of the global population [12]. Significant variation in the prevalence of tinnitus was reported from numerous studies across Middle Eastern countries. Estimates of tinnitus prevalence in the general population have been reported at 30.6% in Palestine [7], 33% in Turkey [13], 5.2% in Egypt [14], and 4.6% in Iran [15]. The prevalence of tinnitus in children has been reported to range from 7.5% to 60% [12,16]. Tinnitus is believed to be more common in children with hearing impairment compared with children with normal hearing [17].

In Palestine, the prevalence of tinnitus has been estimated at 30.6% among adults [7] and 31% among university students [18]. Yet data on Palestinian adolescents remain scarce. This represents a critical gap, as tinnitus is increasingly recognized as a condition with significant psychosocial dimensions beyond its auditory characteristics [19]. In adolescents, tinnitus may be closely intertwined with psychological stress, anxiety, sleep disturbance, and daily functioning [20,21], particularly during a developmental stage characterized by academic pressure and heightened emotional sensitivity [22]. These impacts can substantially affect quality of life, emotional equilibrium, and social engagement [23,24]. Conceptualizing tinnitus within a biopsychosocial framework is therefore essential to understanding its mechanisms and risk factors in young populations, as well as for addressing its potential effects on their quality of life [25]. Therefore, the current study aims to examine the prevalence and risk factors of tinnitus among Palestinian children aged 15–18 years.

Methods

Study design and population

A cross-sectional questionnaire-based study was conducted from January to March 2025 to assess the prevalence of tinnitus and its associated risk factors.

The sample size was calculated using Cochran’s formula for prevalence studies:

Assuming a 95% confidence level (Z = 1.96), an expected prevalence of 50% (p = 0.5; no prior regional data), and a 5% margin of error (e = 0.05), the initial sample size was determined to be 385 participants. Given the large target population (N ≈ 340,000), the finite population correction had a negligible impact, and the sample size remained unchanged. To account for potential non-response, the target was increased by 15%, resulting in a final sample size of 443 participants.

Study setting, sampling method, and data collection procedure

The study involved a population survey of Palestinians aged from 15 to 18 years. The population included individuals from all four governorates of the West Bank in Palestine. The participants in this study were recruited from different settings across the West Bank in Palestine to ensure a representative sample. Participants were recruited by selecting individuals from local community centers and social media platforms. The questionnaire was shared with people and friends, including researchers’ accounts, to reach a larger number of community participants, enabling a deeper understanding of the study’s findings.

Given the contextual limitations in Palestine, such as restricted institutional access, lack of centralized databases for adolescents, and logistical barriers due to political instability, probability-based sampling strategies were not feasible. Therefore, a large-scale convenience sampling approach was employed, which is a commonly used method in public health research in low-resource or conflict-affected settings. This approach allowed us to efficiently collect data from a broad and diverse sample and generate early epidemiological insights on tinnitus, a condition for which there is limited evidence in this population.

Study tools

The study’s questionnaire was based on the European School for Interdisciplinary Tinnitus Research-Screening Questionnaire (ESIT-SQ), a self-report tinnitus-relevant history questionnaire (supplementary file) [23]. Public health and speech disorders professionals examined and updated the questionnaire before distribution. The questionnaire comprised questions addressing the sociodemographic data, clinical characteristics of the participants, the characteristics of tinnitus, inciting triggers, treatment approaches, and responses to therapy among the tinnitus-affected participants. The questionnaire was an Arabic translation version of ESIT-SQ, which was used as a study tool in a recent Palestinian studies, the questionnaire underwent a forward-backward translation process to ensure language accuracy in prior research [7,18]. The study questionnaire was distributed digitally through email, institutional platforms, etc. Participation was entirely voluntary. A pilot study was executed before the comprehensive data collection to evaluate the clarity, relevance, and feasibility of the questionnaire. The pilot research data were excluded from the final analysis. The study was conducted using a digital questionnaire created via Google Forms. At the beginning of the form, an electronic informed consent statement was presented. Only participants who clicked “I agree” were able to proceed with the rest of the questionnaire. This ensured that informed consent was obtained digitally and voluntarily before any data were collected. To minimize respondent fatigue, the survey platform allowed participants to pause and resume, reducing the likelihood of inconsistent responses toward the end. A total of 1131 responses were received from participants who agreed and completed the questionnaire.

Data analysis

The statistical analyses were carried out using IBM Corp.‘s Statistical Package for the Social Sciences version 25 (SPSS 25) in Armonk, New York, USA. Data was analyzed descriptively, with categorical variables expressed as frequency and percentage. To examine associations between tinnitus and various socio-demographic and clinical variables, Chi-square tests or Fisher’s exact tests (as appropriate, based on cell counts) were performed for bivariate comparisons. A p-value of < 0.05 was considered statistically significant. Variables that showed significant associations in the bivariate analysis were subsequently entered into a binary multivariate logistic regression model to identify independent predictors of tinnitus. In addition, the association between the subtypes of tinnitus (objective vs. subjective tinnitus, continuous vs. intermittent tinnitus) and the characteristics of participants with tinnitus was evaluated using the chi-square and, followed by the binary logistic regression for significant variables to determine the predictive independent variables. The enter method was used for variable entry. Results were reported as adjusted odds ratios (ORs) with 95% confidence intervals (CIs).

Ethical consideration

The Institutional Review Board (IRB) of An-Najah University provided its approval for this study, which was conducted in accordance with ethical standards and was performed in compliance with the Helsinki Declaration for research in humans (Reference: BioMed. Dec.2024/23). Before inclusion, all participants provided written informed consent to take part in the study. All participants provided informed consent before proceeding to the online questionnaire questions, and those who did not sign the consent form were not allowed to participate. The permission form explained the study’s goal and guaranteed voluntary and anonymous participation, with no consequences for nonparticipation.

Results

The study population

The survey included 1131 participants. 35.5% were male, and 64.5% were female. The participants’ ages ranged from 15 to 18 years, with 30.2% being 15 years old, 32.2% being 16 years old, 28.2% being 17 years old, and 9.4% being 18 years old. The majority of the participants had a normal BMI (66%), with 16.5% underweight, 13.5% overweight, and 3.9% obese. Regarding city of residence, 37.3% were from Hebron, 25.2% from Nablus, 30.6% from Ramallah, and 6.9% from Bethlehem. 62% of participants reported high phone usage. The majority of participants (85.9%) were right-handed. Among the participants, 8.5% reported having a mother with tinnitus, 5% a father, 3.9% brothers, and 4% sisters with tinnitus. 46.7% of the participants didn’t know if they had first-degree relatives with tinnitus, while 40.4% reported having no relatives with tinnitus. Among those who reported having relatives with tinnitus, the mean number of affected relatives was 1.92 ± 1.292. Table 1 displays the participants’ characteristics.

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Table 1. Background characteristics of the study participants, descriptive statistics of the sample characteristics (n = 1131).

https://doi.org/10.1371/journal.pone.0344420.t001

Clinical characteristics of the participant

Table 2 presents the clinical features of the study participants. Regarding dizziness, 42.7% reported experiencing it more than once a year, 26.1% less than once a year, and 31.2% reported no dizziness. Among ear-related conditions, acoustic trauma due to sudden loud noise affected 3.6%, and middle ear infection due to external pressure was present in 8.4%. Notably, age-related hearing loss, acoustic neuroma, otosclerosis, and sudden hearing loss were rare, each affecting less than 1% of participants. A significant majority, 82.6%, reported no ear-related conditions. In terms of prior medical procedures, 20.2% had undergone dental procedures, and 2.3% had ear surgery, while a substantial 74.8% reported no prior medical procedures. Sensitivity to external sounds in the past week was observed in 34.7% of participants. Regarding hearing difficulties, 42.4% reported slight difficulty hearing in noisy environments, and 2.9% reported complete hearing loss. The use of hearing assistive devices was uncommon, with only 0.7% using hearing aids and even smaller percentages using cochlear implants, sound generators, or combined devices. Headache was a prevalent symptom, affecting 41.9% of the participants. Psychological conditions were also common, with 37.7% experiencing anxiety or excessive stress. Sleep disturbances were present in 32.9% of participants who reported difficulty falling asleep. In contrast, several conditions demonstrated low prevalence within the participant group. For instance, within the cardiovascular conditions, myocardial infarction (heart attack) was reported by only 0.2% of participants. Among other conditions, Familial Mediterranean Fever, HSV (Herpes Simplex Virus), Helicobacter pylori, Iron Deficiency, Leukemia, OCD (obsessive-compulsive disorder), Schizophrenia, and Parkinson’s disease each affected a mere 0.1%. Detailed descriptions of these clinical characteristics are presented in Table 2.

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Table 2. Clinical characteristics of the study participants (n = 1131).

https://doi.org/10.1371/journal.pone.0344420.t002

Prevalence of tinnitus and its characteristics

Of the participants affected by tinnitus (n = 532), 12.6%, 17.9%, and 13.5% experienced it daily or almost daily, weekly, and monthly, respectively. The majority of participants (28.2%) experienced tinnitus every few months, with 27.8% experiencing it yearly. 32.7% of those affected reported constant tinnitus, while 67.3% reported intermittent tinnitus. Tinnitus sounded like a cricket in 34.8% of the affected participants, and 27.6% perceived it as tonal. Tinnitus was perceived inside the head by 25.6% of the participants. The majority of tinnitus cases (74.1%) had no rhythm. At least 6% of individuals reported tinnitus audible to the clinician. The results are presented in Table 3.

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Table 3. Characteristics of tinnitus among the affected participants (n = 532).

https://doi.org/10.1371/journal.pone.0344420.t003

As presented in Table 4, for many, tinnitus onset was unclear, with 57.7% not knowing when it began. In a small number of cases, tinnitus occurred before (2.6%), after (4.3%), or around the same time (1.1%) as other related conditions. Prominent conditions associated with tinnitus onset included exposure to loud sounds (28.2%), flu, common cold, or other infections (21.6%), and anxiety (20.9%). Concerning drug intake among respondents, 16.7% reported using pain relievers, while smaller percentages reported using antibiotics (9.2%), aspirin (1.9%), or quinine (1.9%). In terms of management, Table 5 shows that the majority of participants didn’t seek professional help, with 71.5% reporting they had never seen a healthcare professional for their tinnitus.

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Table 4. Onset of tinnitus-associated conditions and respondent drug intake (n = 532).

https://doi.org/10.1371/journal.pone.0344420.t004

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Table 5. Management of tinnitus (n = 532).

https://doi.org/10.1371/journal.pone.0344420.t005

Tinnitus-associated factors

Table 6 presents the factors potentially associated with tinnitus. The Chi-square and Fisher’s exact tests revealed that several factors were significantly associated with tinnitus (p-value < 0.05). These factors included demographic variables such as age and gender, as well as a family history of tinnitus, specifically in the mother, brothers, or participants who reported “I don’t know” or “None.” Significant associations were also found with symptoms like dizziness and various ear-related conditions, including acoustic trauma from sudden loud noise, middle ear infections due to external pressure, sudden hearing loss, middle ear infections or Eustachian tube dysfunction, and even the absence of any ear-related conditions. Medical history, such as previous dental procedures or the absence of any procedures, was also significant. Other associated variables included sensitivity to external sounds, difficulty hearing in noisy environments, and a range of symptoms such as headache, neck pain, ear pain, jaw pain, facial pain, or the absence of pain. Additionally, oral health issues like Jaw joint pain and dental problems, neurological conditions such as epilepsy and multiple sclerosis, and psychological conditions including anxiety or excessive stress, depression, and emotional trauma were all significantly linked to tinnitus. Sleep problems, particularly difficulty falling asleep and staying asleep, were also associated. Further medical conditions, such as high blood pressure, thyroid dysfunction, high cholesterol, rheumatoid arthritis, chronic sinusitis, deviated nasal septum, anemia, balance disorders, and gastroesophageal reflux disease (GERD), showed significant relationships with tinnitus as well.

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Table 6. Association between the presence of tinnitus with socio-demographic and clinical characteristics.

https://doi.org/10.1371/journal.pone.0344420.t006

Binary logistic regression analysis of the associations between tinnitus and influencing factors

Predictors of tinnitus were determined by entering significant variables from the Chi-square and Fisher’s exact analysis into a binary logistic regression model. The analysis revealed that individuals aged 17 were significantly more likely to have tinnitus by 1.5 times compared to those aged 15 (p = 0.038, 95% CI: 1.023–2.157). Additionally, reporting first-degree relatives had tinnitus was significantly associated with an approximately threefold increased risk of tinnitus (p = 0.010, 95% CI: 1.277–6.044). Moreover, higher sensitivity to external sounds during the past week was significantly associated with tinnitus, with a 2.7 times increased likelihood compared to those who didn’t report such sensitivity (p < 0.001, 95% CI: 1.971–3.711). Slight difficulty hearing in noisy environments was also significantly associated with tinnitus, increasing the likelihood by 1.7 times compared to those without such difficulty (p < 0.001, 95% CI: 1.261–2.314). Reporting pain symptoms was significantly associated with tinnitus, doubling the risk compared to those who didn’t report experiencing pain (p = 0.033, 95% CI: 1.057–3.805). Lastly, difficulty falling asleep was associated with a 1.8-fold higher risk of tinnitus compared to those who didn’t report such difficulty (p < 0.001, 95% CI: 1.270–2.462). Results are shown in Table 7.

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Table 7. Logistic regression analysis of the associations between tinnitus and influencing factors.

https://doi.org/10.1371/journal.pone.0344420.t007

Binary logistic regression analysis of the associations between tinnitus subtypes and influencing factors

Within the group of participants with tinnitus (n = 532), the predictor variables were evaluated. The variables that were significant in the chi-square analysis (results not included) were introduced into the logistic regression analysis to determine the predictors for having objective tinnitus compared with the subjective subtype and intermittent tinnitus compared with the continuous subtype. Table 8 shows the variables that were significantly associated with having objective or subjective tinnitus in the first column; however, the variables that were significant predictors of having objective tinnitus based on the logistic regression were just having epilepsy and migraine. Participants with tinnitus who have epilepsy are more likely to have objective tinnitus by around 9 times (p = 0.001, 95% CI: 2.59–37.579). Additionally, participants with tinnitus who have migraine are more likely to have objective tinnitus by around 16 times (p = 0.032, 95% CI: 1.268–208.176). Table 9 shows the variables that were significantly associated with having intermittent or continuous tinnitus in the first column; however, the variables that were significant predictors for continuous tinnitus were prior tonsillectomy and sensitivity to external sounds. Participants with tinnitus who have had tonsillectomy are less likely to have continuous tinnitus (OR: 0.164), (p = 0.03, 95% CI: 0.032–0.836). Additionally, participants with tinnitus who were sensitive to external sounds are also less likely to have continuous tinnitus (OR: 0.0619), (p = 0.013, 95% CI: 0.424–0.903).

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Table 8. Logistic regression analysis of the associations between tinnitus form (subjective vs. objective) and the patients’ characteristics.

https://doi.org/10.1371/journal.pone.0344420.t008

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Table 9. Logistic regression analysis of the associations between tinnitus form (intermittent vs. continuous) and the patients’ characteristics.

https://doi.org/10.1371/journal.pone.0344420.t009

Discussion

The reported tinnitus prevalence in the current study is 47% among Palestinian young people aged 15–18 years old, which is notably high. The significant association between age and tinnitus in the current study, with older teenager (17-year-olds) exhibiting a 1.5-fold increased risk compared to younger studied group (15-year-olds). This is supported by previous studies that showed the prevalence of tinnitus increases with age [1,26,27] and among adolescents, those in their mid-teens have the highest incidence of tinnitus [26]. The single-year ages of 15 and 17 years examined in the present study both fall unequivocally within middle adolescence from a developmental perspective [20]. Their comparison should not be viewed as representing discrete developmental stages. The use of age ranges in adolescent research is theoretically based on the understanding that development during this life stage is continuous, non-linear, and not limited by rigid chronological limits, acknowledging contemporary perspectives that emphasize the fluidity and extended upper boundary of adolescence [28]. Adolescence is still a relatively understudied and developing life stage, with growing understanding that its upper boundary goes beyond traditional bounds.

Gender differences, more prevalent among females, align with prior research findings [2931]. This may be due to the greater tendency of girls to describe symptoms [32] and their more frequent generation of spontaneous otoacoustic emissions [33]. Our results revealed that tinnitus was more prevalent in females (50.7%) than in males (40.4%). Increased prevalence of tinnitus and tinnitus annoyance in females was also shown in a survey on the population of South Korea by Park et al. Those authors attributed their findings to the more stressful cultural situation of South Korean women, which demands female obedience and more roles for women within the family [34]. Palestinian females suffer similar cultural stressors in addition to political violence arising from the military occupation [35], which may have contributed to the increased perception of tinnitus in girls in our study. On the other hand, the decreased prevalence of tinnitus in Palestinian males may arise from the tendency of males to not declare their health problems [36].

Notably, the current study indicated that a positive family history of tinnitus increases the risk of developing tinnitus. This finding is in line with a previous study on tinnitus among Palestinian university students [18]. These notes support recent hypotheses about the possible genetic component in the etiology of tinnitus [37]. A recent genome-wide association study highlighted several significant pathways implicated in tinnitus [38]. Another study on tinnitus found a higher concordance rate in monozygotic twins compared to dizygotic twins [39]. Nevertheless, other large-scale studies have reported low heritability estimates for tinnitus and concluded that a strong association with any specific genetic locus is lacking [40]. It is frequently challenging to distinguish whether familial aggregation is caused by common genes or shared environmental factors, even though it has been demonstrated for many, if not all, disorders [41]. The existence of a familial impact for tinnitus allows for targeted research to ascertain if genetic factors or a shared familial environment are responsible for this effect [42]. Families are frequently exposed to the same environmental risks, eat comparable meals, and reside in the same geographic area. These common exposures may raise the chance of contracting specific illnesses, which could result in familial aggregation [43]. Because families live near one another and share living quarters, infectious diseases can spread readily within them. This may cause several family members to contract the same virus, giving the impression that there is a hereditary connection when in fact it is the result of transmission [44]. Family dynamics, stress levels, and learned coping mechanisms can also play a role. For example, a family with high levels of chronic stress might experience a higher prevalence of stress-related illnesses, even without a genetic predisposition [43]. Further collaborative attempts are necessary to provide biological insight into the potential genetic etiology of tinnitus.

Tinnitus in our sample frequently co-occurred with symptoms such as dizziness, sound sensitivity, headaches, and sleep disturbances, reflecting the multifaceted nature of the condition. These findings are consistent with previous research indicating that tinnitus often co-occurs with other auditory and non-auditory symptoms, including hyperacusis and psychological distress [45]. This study found a substantial association between disturbances in sleeping, especially difficulty in initiating sleep, and tinnitus. This corresponds with meta-analyses indicating that more than fifty percent of tinnitus sufferers suffer from sleep disturbances. The reciprocal association between tinnitus and sleep disruptions indicates that therapies aimed at improving sleep quality may positively impact tinnitus severity and vice versa [46].

According to the data, those affected experienced varying frequencies of tinnitus. Participants had tinnitus on a monthly, weekly, and daily basis with 13.5%, 17.9%, and 12.6% respectively, while a major proportion of participants experienced tinnitus every few months (28.2%) and yearly (27.8%). The frequency of tinnitus differs among individuals, suggesting it is a symptom rather than a disease, with multiple potential etiologies contributing to its onset. The figures indicate that a significant percentage of individuals experience tinnitus monthly, weekly, or daily. This data aligns with the evolving characteristics of tinnitus, emphasizing the necessity for a more profound understanding of its impact on individuals’ lives [47]. The other characteristics of tinnitus in our study sample confirm the disorder’s variability, with 32.7% reporting constant tinnitus and 67.3% experiencing intermittent tinnitus. The most prevalent tinnitus noises are crickets at 34.8%, noise at 25.7%, and tone sounds at 27.6%. Greater variation exists in the tinnitus rhythm, the affected ear, and whether it is subjective or objective. Notably, tinnitus is reported bilaterally in approximately 41% of our study population, indicating a potential association with systemic rather than localized disorders, such as Ménière’s disease, vestibular schwannoma, atmospheric inner ear barotrauma, vertebrobasilar ischemic stroke, and otosclerosis [48,49]. Although the precise etiology of tinnitus remains unclear, numerous risk factors have been identified. Multiple environmental and health-related factors were identified as associated with tinnitus. Older age, female, history of smoking, sleep disturbances, stress, exposure to noise, and a history of various medical conditions such as arthritis, asthma, and thyroid disorders have been identified as risk factors for tinnitus [9,31].

A significant proportion of respondents (57.7%) reported uncertainty about the onset of their tinnitus, indicating a potential lack of awareness or difficulty in pinpointing the exact timing of symptoms. The high proportion of uncertain responses regarding tinnitus onset reflects findings from Rosing et al. (2016), who noted similar challenges in pediatric tinnitus case histories. Among those who could recall, the majority (18.4%) experienced tinnitus within the past 1–12 months, followed by 13.5% reporting onset within 13–24 months. This suggests that tinnitus may often develop relatively recently in this population, though a subset (2.6%) reported symptoms persisting for over 36 months. The high percentage of uncertain responses underscores the need for improved education and awareness about tinnitus in adolescents [29]. The timing of tinnitus-associated conditions relative to tinnitus onset revealed that only a small fraction of respondents (2.6%) experienced these before tinnitus began, while 4.3% reported conditions arising after tinnitus started. A negligible proportion (1.1%) noted coincident timing. The low percentages suggest that while some conditions may be linked to tinnitus, the majority of cases (92.8%) either had no clear association or were unknown. This highlights the complexity of identifying direct causative factors and the need for further research into underlying mechanisms.

Regarding medication use, the majority of respondents (59.2%) reported no drug intake, which contrasts with adult populations [50], suggesting different risk profiles in adolescents. The pain relievers use (16.7%) could imply a potential association with over-the-counter medications [51]. Antibiotics were reported by 9.2% of respondents, raising questions about ototoxic effects in some cases. However, the high percentage of “I don’t know” responses (16.5%) indicates a need for better documentation and awareness of medication histories in this population. These findings emphasize the multifactorial nature of tinnitus in adolescents, with noise exposure, infections, and anxiety emerging as prominent risk factors [6]. The high prevalence of uncertainty regarding onset and associated conditions highlights the challenges in diagnosing and managing tinnitus in this age group. Public health efforts should focus on preventive measures, such as hearing protection and awareness campaigns, while clinicians should consider comprehensive evaluations that include mental health and medication histories [52].

The finding that 71.5% of participants had never sought professional help for tinnitus underscores a widespread reluctance or barrier to care. A recent scoping review reported that across diverse populations, fewer than one-third of individuals with tinnitus pursue medical evaluation, often due to beliefs that nothing can be done or low perceived severity [53]. Likewise, in Saudi Arabia, despite a prevalence of 37.6%, only a minority sought medical support, mirroring our finding of low help-seeking behavior [54].

Inner-ear pathologies such as acoustic trauma, middle-ear infections, and sudden hearing loss were significantly linked to tinnitus in our cohort, consistent with reports that cochlear injury and Eustachian tube dysfunction predispose to aberrant neural firing underlying phantom sound perception. Dizziness and balance disorders often coexist with tinnitus, reflecting shared vestibular–auditory pathophysiology [55]. Tinnitus frequently co-occurs with psychiatric conditions: anxiety, depression, and post-traumatic stress have been shown to exacerbate tinnitus distress and may influence its onset [56]. Sleep disturbances, particularly insomnia, both worsen symptom perception and are a consequence of tinnitus-related arousal. Pain syndromes—including headache, neck pain, and temporomandibular disorders—share convergent neural circuits with tinnitus, potentially explaining the association we observed [57]. Importantly, these findings highlight the necessity of adopting a biopsychosocial framework when interpreting tinnitus in adolescents [19]. In our Palestinian sample, the high prevalence of anxiety, stress, and sleep disturbances may reflect not only individual predisposition but also broader contextual stressors, including ongoing political conflict [58], academic pressures [22], and restricted access to healthcare [58], that can amplify tinnitus perception and distress. This underscores that tinnitus in this population cannot be understood through biological pathways alone but must account for the psychosocial environment in which these adolescents develop. Moreover, while tinnitus emerged as a reported symptom, it should be understood within the broader context of trauma-related conditions such as PTSD, particularly in conflict-affected areas such as Palestine, where the population, including all age groups, is frequently experiencing collective violence and adverse childhood experiences (ACEs) [59].

In our multivariate model, six factors emerged as independent predictors of tinnitus: adolescents aged 17 showed a 1.5-fold higher risk compared to those aged 15 (p = 0.038, 95% CI: 1.023–2.157), consistent with documented increases in tinnitus prevalence during late adolescence and early adulthood [60]; having a first-degree family history of tinnitus conferred approximately a threefold elevated risk (p = 0.010, 95% CI: 1.277–6.044), underscoring genetic predisposition evidenced by familial aggregation and heritability studies [61,62]; recent sensitivity to external sounds—hyperacusis—was associated with a 2.7-times greater likelihood of tinnitus (p < 0.001, 95% CI: 1.971–3.711), in line with the tight comorbidity observed between these conditions [63]; slight difficulty hearing in noisy environments increased the odds by 1.7 times (p < 0.001, 95% CI: 1.261–2.314), reflecting early sensorineural deficits as precursors to tinnitus [64]; reporting pain symptoms doubled the risk of tinnitus (p = 0.033, 95% CI: 1.057–3.805), corroborating population-based associations between chronic pain and tinnitus [65]; and difficulty falling asleep was linked to a 1.8-fold increased risk (p < 0.001, 95% CI: 1.270–2.462), consistent with evidence that insomnia both predisposes to and exacerbates tinnitus distress [66].

Conclusions

This study demonstrates a remarkably high prevalence of tinnitus among young Palestinians aged 15–18. The findings suggest that tinnitus onset and severity are influenced by a number of risk factors, particularly age, family history, sleep disturbances, and comorbid symptoms such as hyperacusis and pain. A significant association between tinnitus and positive family history of tinnitus was noted, supporting the hypothesis of a genetic role. These findings underscore the need for targeted public health initiatives to raise awareness, promote early identification, and encourage appropriate management of tinnitus among adolescents.

Recommendations

Future research should aim to clarify causal relationships and further explore the genetic, environmental, and psychosocial contributors to tinnitus in young populations. In particular, subtype-specific risk analysis, distinguishing between continuous vs. intermittent, subjective vs. objective tinnitus, and tinnitus with or without ear-related comorbidities, will be crucial for advancing knowledge and clinical practice. Such analyses will require larger or clinically enriched samples to enable sufficient statistical power and more targeted prevention and intervention strategies. Additionally, future studies should collect medication use data from all participants, regardless of tinnitus status, to enable a more robust assessment of the potential role of analgesics in the onset and severity of tinnitus. Future studies should incorporate comprehensive audiological and otologic evaluations to improve diagnostic accuracy and allow for clearer differentiation of tinnitus subtypes. Collaboration with audiologists and otolaryngologists is recommended to provide a more clinically grounded understanding of tinnitus and its underlying risk factors.

Limitations

This study has several limitations to be considered when interpreting the results. First, its cross-sectional design limits our ability to establish causal relationships, as data were collected at a single point in time. Second, the reliance on self-reported measures may introduce information bias due to recall inaccuracies or subjective interpretations. Third, while the study included a large sample of Palestinian adolescents, the use of convenience sampling, necessitated by Ministry of Education restrictions and mobility barriers during the ongoing conflict, may introduce selection bias that could affect prevalence estimates. The non-probability sampling design does not allow formal estimation of the magnitude or direction of this bias; therefore, the findings should be interpreted with caution and cannot be generalized to the broader Palestinian population. Additionally, the absence of objective audiological assessments and otologic evaluations limits the ability to clinically verify tinnitus and differentiate between tinnitus subtypes. The prevalence of tinnitus might be overestimated in the current study, as individuals with pre-existing auditory problems may have been more motivated to participate. Individuals with access to digital platforms were able to participate, which represents an additional bias in participation. Since identity confirmation was not applicable in our study setting, the precision of age-specific findings requires future studies with stricter verification protocols.

Acknowledgments

We thank everyone who contributed their time to make this project a reality. Likewise, we are grateful to the faculty of medicine and health sciences of An-Najah National University for their affordable collaboration.

References

  1. 1. Al-Swiahb J, Park SN. Characterization of tinnitus in different age groups: a retrospective review. Noise Health. 2016;18(83):214–9. pmid:27569409
  2. 2. Bhimrao SK, Masterson L, Baguley D. Systematic review of management strategies for middle ear myoclonus. Otolaryngol Head Neck Surg. 2012;146(5):698–706. pmid:22261497
  3. 3. Ramly NA, Roslenda AR, Suraya A, Asma A. Vascular loop in the cerebellopontine angle causing pulsatile tinnitus and headache: a case report. EXCLI J. 2014;13:192–6. pmid:26417253
  4. 4. Sedley W. Tinnitus: does gain explain?. Neuroscience. 2019;407:213–28.
  5. 5. Patil JD, Alrashid MA, Eltabbakh A, Fredericks S. The association between stress, emotional states, and tinnitus: a mini-review. Front Aging Neurosci. 2023;15:1131979. pmid:37207076
  6. 6. Baguley D, McFerran D, Hall D. Tinnitus. The Lancet. 2013;382(9904):1600–7.
  7. 7. Al-Lahham S, Nazzal Z, Massarweh A, Saymeh D, Al-Abed S, Muhammad D, et al. Prevalence and associated risk factors of tinnitus among adult Palestinians: a cross-sectional study. Sci Rep. 2022;12(1):20617. pmid:36450754
  8. 8. Boecking B, Klasing S, Walter M. Vascular-metabolic risk factors and psychological stress in patients with chronic tinnitus. 2022;14(11).
  9. 9. Kim H-J, Lee H-J, An S-Y, Sim S, Park B, Kim SW, et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One. 2015;10(5):e0127578. pmid:26020239
  10. 10. Cianfrone G, Mazzei F, Salviati M, Turchetta R, Orlando MP, Testugini V, et al. Tinnitus holistic simplified classification (thosc): a new assessment for subjective tinnitus, with diagnostic and therapeutic implications. Ann Otol Rhinol Laryngol. 2015;124(7):550–60. pmid:25725038
  11. 11. Gallus S, Lugo A, Garavello W, Bosetti C, Santoro E, Colombo P, et al. Prevalence and determinants of Tinnitus in the Italian adult population. Neuroepidemiology. 2015;45(1):12–9. pmid:26182874
  12. 12. Møller AR, Langguth B, DeRidder D, Kleinjung T. Textbook of tinnitus. Springer Science & Business Media. 2010.
  13. 13. Günay O, Borlu A, Horoz D, Günay İ. Tinnitus prevalence among the primary care patients in Kayseri, Turkiye. Erciyes Medical Journal. 2011;33(1):39–46.
  14. 14. Khedr EM, Ahmed MA, Shawky OA, Mohamed ES, El Attar GS, Mohammad KA. Epidemiological study of chronic tinnitus in Assiut, Egypt. Neuroepidemiology. 2010;35(1):45–52. pmid:20389124
  15. 15. Jalessi M, Farhadi M, Asghari A, Kamrava SK, Amintehran E, Ghalehbaghi S, et al. Tinnitus: an epidemiologic study in Iranian population. Acta Med Iran. 2013;51(12):886–91. pmid:24442544
  16. 16. Esmaili AA, Renton J. A review of tinnitus. Aust J Gen Pract. 2018;47(4):205–8. pmid:29621860
  17. 17. Kentish R. Managing tinnitus in childhood. In: Baguley D, Fagelson M, editors. Tinnitus: clinical and research perspectives. Plural Publishing. 2016.
  18. 18. Alqub M, Tourman N, Mousa J, Humead N, Abd Alrazeq A, Khatatbh A, et al. Tinnitus prevalence and associated risk factors among university students: A cross-sectional study. SAGE Open Med. 2024;12:20503121241283344. pmid:39376496
  19. 19. Cima RFF, Mazurek B, Haider H, Kikidis D, Lapira A, Noreña A, et al. A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. Hno. 2019;67(Suppl 1):10–42.
  20. 20. Kim SY, Jeon YJ, Lee J-Y, Kim YH. Characteristics of tinnitus in adolescents and association with psychoemotional factors. Laryngoscope. 2017;127(9):2113–9. pmid:27774600
  21. 21. Tegg-Quinn S, Bennett RJ, Brennan-Jones CG, Barabash S, Mulders WH, Eikelboom RH. Reflections and perceptions of chronic tinnitus during childhood and adolescence. Int J Pediatr Otorhinolaryngol. 2020;138:110258. pmid:32823204
  22. 22. Wang J, Wang Z, Yang Y, Wang T, Lin H, Zhang W, et al. Academic Burden and Emotional Problems Among Adolescents: A Longitudinal Mediation Analysis. J Adolesc. 2025;97(4):989–1001. pmid:39835663
  23. 23. Genitsaridi E, Partyka M, Gallus S, Lopez-Escamez JA, Schecklmann M, Mielczarek M, et al. Standardised profiling for tinnitus research: the European school for interdisciplinary tinnitus research screening questionnaire (ESIT-SQ). Hear Res. 2019;377:353–9. pmid:30871820
  24. 24. Kennedy V, Wilson C, Stephens D. Quality of life and tinnitus. Audiological Medicine. 2004;2(1):29–40.
  25. 25. Shetye A, Kennedy V. Tinnitus in children: an uncommon symptom?. Arch Dis Child. 2010;95(8):645–8. pmid:20371585
  26. 26. Rhee J, Lee D, Suh MW, Lee JH, Hong Y-C, Oh SH, et al. Prevalence, associated factors, and comorbidities of tinnitus in adolescents. PLoS One. 2020;15(7):e0236723. pmid:32735626
  27. 27. Martinez C, Wallenhorst C, McFerran D, Hall DA. Incidence rates of clinically significant tinnitus: 10-year trend from a cohort study in England. Ear Hear. 2015;36(3):e69-75. pmid:25470370
  28. 28. Baird S, Choonara S, Azzopardi PS, Banati P, Bessant J, Biermann O, et al. A call to action: the second Lancet Commission on adolescent health and wellbeing. Lancet. 2025;405(10493):1945–2022. pmid:40409329
  29. 29. Rosing SN, Schmidt JH, Wedderkopp N, Baguley DM. Prevalence of tinnitus and hyperacusis in children and adolescents: a systematic review. BMJ Open. 2016;6(6):e010596. pmid:27259524
  30. 30. Mahboubi H, Oliaei S, Kiumehr S, Dwabe S, Djalilian HR. The prevalence and characteristics of tinnitus in the youth population of the United States. Laryngoscope. 2013;123(8):2001–8. pmid:23606449
  31. 31. Bhatt IS. Prevalence of and risk factors for Tinnitus and Tinnitus-Related Handicap in a college-aged population. Ear Hear. 2018;39(3):517–26. pmid:29068861
  32. 32. Eley TC, Lichtenstein P, Stevenson J. Sex differences in the etiology of aggressive and nonaggressive antisocial behavior: results from two twin studies. Child Dev. 1999;70(1):155–68. pmid:10191520
  33. 33. Penner MJ. Linking spontaneous otoacoustic emissions and tinnitus. Br J Audiol. 1992;26(2):115–23. pmid:1628116
  34. 34. Park KH, Lee SH, Koo J-W, Park HY, Lee KY, Choi YS, et al. Prevalence and associated factors of tinnitus: data from the Korean National Health and Nutrition Examination Survey 2009-2011. J Epidemiol. 2014;24(5):417–26. pmid:24953134
  35. 35. Sousa CA, Kemp S, El-Zuhairi M. Dwelling within political violence: palestinian women’s narratives of home, mental health, and resilience. Health Place. 2014;30:205–14. pmid:25306419
  36. 36. Tudiver F, Talbot Y. Why don’t men seek help? Family physicians’ perspectives on help-seeking behavior in men. J Fam Pract. 1999;48(1):47–52. pmid:9934383
  37. 37. Vona B, Nanda I, Shehata-Dieler W, Haaf T. Genetics of Tinnitus: still in its infancy. Front Neurosci. 2017;11:236. pmid:28533738
  38. 38. Bhatt IS, Wilson N, Dias R, Torkamani A. A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders. Sci Rep. 2022;12(1):22511. pmid:36581688
  39. 39. Lopez-Escamez JA, Amanat S. Heritability and genetics contribution to tinnitus. Otolaryngologic Clinics of North America. 2020;53(4):501–13.
  40. 40. Kvestad E, Czajkowski N, Engdahl B, Hoffman HJ, Tambs K. Low heritability of tinnitus: results from the second Nord-Trøndelag health study. Arch Otolaryngol Head Neck Surg. 2010;136(2):178–82. pmid:20157066
  41. 41. Khoury MJ, Beaty TH, Liang KY. Can familial aggregation of disease be explained by familial aggregation of environmental risk factors?. Am J Epidemiol. 1988;127(3):674–83. pmid:3341366
  42. 42. Hendrickx JJ, Huyghe JR, Demeester K, Topsakal V, Van Eyken E, Fransen E. Familial aggregation of tinnitus: a European multicentre study. B-ENT. 2007;3(Suppl 7):51–60.
  43. 43. Institute of Medicine Committee on Assessing Interactions Among Social B, Genetic Factors in H. Genes, behavior, and the social environment: Moving beyond the nature/nurture debate. In: Hernandez LM, Blazer DG, editors. The National Academies Collection: Reports funded by National Institutes of Health. Washington (DC): National Academies Press (US). 2006.
  44. 44. Matthews AG, Finkelstein DM, Betensky RA. Analysis of familial aggregation studies with complex ascertainment schemes. Stat Med. 2008;27(24):5076–92. pmid:18618413
  45. 45. Fioretti AB, Fusetti M, Eibenstein A. Association between sleep disorders, hyperacusis and tinnitus: evaluation with tinnitus questionnaires. Noise Health. 2013;15(63):91–5. pmid:23571298
  46. 46. Gu H, Kong W, Yin H, Zheng Y. Prevalence of sleep impairment in patients with tinnitus: a systematic review and single-arm meta-analysis. Eur Arch Otorhinolaryngol. 2022;279(5):2211–21. pmid:34708282
  47. 47. Langguth B, Kreuzer PM, Kleinjung T, De Ridder D. Tinnitus: causes and clinical management. Lancet Neurol. 2013;12(9):920–30. pmid:23948178
  48. 48. Thompson TL, Amedee R. Vertigo: a review of common peripheral and central vestibular disorders. Ochsner J. 2009;9(1):20–6. pmid:21603405
  49. 49. Newman-Toker DE, Della Santina CC, Blitz AM. Vertigo and hearing loss. Handb Clin Neurol. 2016;136:905–21. pmid:27430449
  50. 50. Cianfrone G, Pentangelo D, Cianfrone F, Mazzei F, Turchetta R, Orlando MP, et al. Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide. Eur Rev Med Pharmacol Sci. 2011;15(6):601–36. pmid:21796866
  51. 51. Sheppard A, Hayes SH, Chen GD, Ralli M, Salvi R. Review of salicylate-induced hearing loss, neurotoxicity, tinnitus and neuropathophysiology. Acta Otorhinolaryngol Ital. 2014;34(2):79–93.
  52. 52. Tunkel DE, Bauer CA, Sun GH, Rosenfeld RM, Chandrasekhar SS, Cunningham ER Jr, et al. Clinical practice guideline: tinnitus. Otolaryngol Head Neck Surg. 2014;151(2 Suppl):S1–40. pmid:25273878
  53. 53. Carmody N, Eikelboom RH, Tegg-Quinn S. Seeking Help for Tinnitus and Satisfaction With Healthcare Providers Including Diagnosis, Clinical Services, and Treatment: A Scoping Review. Eval Health Prof. 2023;46(2):170–93. pmid:36853910
  54. 54. Alkahtani R, Alkhalaf A, Aljabr A, Alharbi D, Almulafikh N, Almotairi S. Tinnitus Prevalence, Impact on Quality of Life, and Health-care-seeking Behavior among Adults: A Cross-sectional Study. Indian Journal of Otology. 2024;30(3):192–8.
  55. 55. Batts S, Stankovic KM. Tinnitus prevalence, associated characteristics, and related healthcare use in the United States: a population-level analysis. Lancet Reg Health Am. 2024;29:100659. pmid:38269207
  56. 56. Beukes EW, Onozuka J, Brazell TP, Manchaiah V. Coping With Tinnitus During the COVID-19 Pandemic. Am J Audiol. 2021;30(2):385–93. pmid:33979227
  57. 57. McFerran DJ, Stockdale D, Holme R, Large CH, Baguley DM. Why Is There No Cure for Tinnitus?. Front Neurosci. 2019;13:802. pmid:31447630
  58. 58. Marie M, SaadAdeen S, Battat M. Anxiety disorders and PTSD in Palestine: a literature review. BMC Psychiatry. 2020;20(1):509. pmid:33066736
  59. 59. Butchart A, Villaveces A, Check P, Phinney A. Preventing violence: a guide to implementing the recommendations of the World report on violence and health. World Health Organisation. 2004.
  60. 60. Meijers SM, de Ruijter JHJ, Stokroos RJ, Smit AL, Stegeman I. The Lifelines Cohort Study: Prevalence of Tinnitus Associated Suffering and Behavioral Outcomes in Children and Adolescents. Ear and Hearing. 2024;45(6).
  61. 61. T. J M, T Y, A D, O. A O, P. A O, A. A A, et al. The impact of occurrence of tinnitus in first degree relatives on the severity of disease among subjects. Int J Otorhinolaryngol Head Neck Surg. 2021;7(2):243.
  62. 62. Biswas R, Genitsaridi E, Trpchevska N, Lugo A, Schlee W, Cederroth CR, et al. Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis. J Assoc Res Otolaryngol. 2023;24(1):81–94. pmid:36380120
  63. 63. Cederroth CR, Lugo A, Edvall NK, Lazar A, Lopez-Escamez JA. Association between hyperacusis and tinnitus. 2020;9(8).
  64. 64. Weilnhammer V, Gerstner D, Huß J, Schreiber F, Alvarez C, Steffens T, et al. Exposure to leisure noise and intermittent tinnitus among young adults in Bavaria: longitudinal data from a prospective cohort study. Int J Audiol. 2022;61(2):89–96. pmid:33787447
  65. 65. Wang C, Li S, Shi M, Qin Z, Wang D, Li W, et al. Association between sleep and tinnitus in US adults: Data from the NHANES (2007–2012). Medicine. 2024;103(43).
  66. 66. Jiang Y, Liu Q, Ding Y, Sun Y. Systematic review and meta-analysis of the correlation between tinnitus and mental health. Am J Otolaryngol. 2025;46(3):104611. pmid:40088765