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Open Access

Retraction

Retraction: Short communication: Upregulation of hypoxia/reoxygenation-induced Shc3 by downregulated miR-455-5p, suppresses trophoblast invasion and is associated with placental inflammation and angiogenesis in preeclampsia

  • The PLOS One Editors

Following the publication of this article [1], concerns were raised about Fig 1. Specifically, there appears to be overlap between panels in Fig 1 in [1], and between the original images in [2], representing different experimental conditions:

  • In Fig 1C, between the panels
    • Invasion (60h) Control and Invasion (60h) miR-455-5p mimic
    • Invasion (60h) Control and Invasion (60h) miR-455-5p mimic-NC
    • Invasion (60h) miR-455-5p mimic and Invasion (60h) miR-455-5p mimic-NC
    • Migration (18h) Control and Migration (18h) miR-455-5p mimic
  • In Figure-1_C.zip [2] between original images
    • invasion-hypoxia-mimic(3).png and invasion-hypoxia-Control(3).png
    • In Figure-1_D.zip [2] between original images
    • invasion-Normoxia-Nc(1).png and invasion-Normoxia-mimic(3).png
    • invasion-Normoxia-Nc(3).png and invasion-Normoxia-mimic(2).png
    • invasion-Normoxia-Nc(3).png and invasion-Normoxia-Control(2).png
    • invasion-Normoxia-mimic(2).png and invasion-Normoxia-Control(2).png
    • Normoxia-mimic(2).png and Normoxia-Control(3).png

In light of the above unresolved concerns that question the reliability and integrity of the results presented in [1], the PLOS One Editors retract this article.

All authors did not agree with the retraction.

References

  1. 1. Gong H-Z, Guan J, Pan Y-Z, Ding H-J, Shi A-W, Gu N. RETRACTED: Short communication: Upregulation of hypoxia/reoxygenation-induced Shc3 by downregulated miR-455-5p, suppresses trophoblast invasion and is associated with placental inflammation and angiogenesis in preeclampsia. PLoS One. 2025;20(1):e0314544. pmid:39792965
  2. 2. Short communication: Upregulation of hypoxia/reoxygenation-induced Shc3 by downregulated miR-455-5p, suppresses trophoblasts invasion and is associated with placental inflammation and angiogenesis in preeclampsia. 2024. Database: Dryad [Internet]. Available from: https://datadryad.org/share/Ejw1WICOw_eD_n6cKla7uWsMtEQfdENe5p1De6eSLDc (Accessed February 6, 2026)).

    Citation: The PLOS One Editors (2026) Retraction: Short communication: Upregulation of hypoxia/reoxygenation-induced Shc3 by downregulated miR-455-5p, suppresses trophoblast invasion and is associated with placental inflammation and angiogenesis in preeclampsia. PLoS One 21(3): e0344272. https://doi.org/10.1371/journal.pone.0344272

    Published: March 5, 2026

    Copyright: © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.