Advertisement
Browse Subject Areas
?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

  • Loading metrics

Open Access

Expression of Concern

Expression of Concern: First identification of resident and circulating fibrocytes in Dupuytren’s disease shown to be inhibited by serum amyloid P and Xiapex

  • The PLOS One Editors

After this article [1] was published, concerns were raised regarding results presented in Fig 6 and the statistical analyses reported in this study.

Specifically:

  • In Fig 6B, part of the Collagenase A 1 µg/ml panel appears similar to part of the Xiapex® 1 µg/ml panel
  • The Statistical Analysis subsection of the Materials and Methods reports that data were analyzed using unpaired two-tailed t-tests, and paired t-test for differences between CT and DD cell counts at each concentration of SAP. However, multiple experiments in this article [1] appear to present more than two variables, suggesting that statistical tests designed for the comparison of multiple variables should have been used instead.

The corresponding author, AB, stated that the data underlying the results in [1] are no longer available, and the underlying data were not provided with the published article [1], contrary to the Data Availability statement. This article [1] therefore does not comply with the PLOS Data Availability policy.

The PLOS One Editors issue this Expression of Concern to inform readers of the above unresolved concerns.

Reference

  1. 1. Iqbal SA, Hayton MJ, Watson JS, Szczypa P, Bayat A. First identification of resident and circulating fibrocytes in Dupuytren’s disease shown to be inhibited by serum amyloid P and Xiapex. PLoS One. 2014;9(6):e99967. pmid:24933153

Citation: The PLOS One Editors (2025) Expression of Concern: First identification of resident and circulating fibrocytes in Dupuytren’s disease shown to be inhibited by serum amyloid P and Xiapex. PLoS One 20(12): e0339113. https://doi.org/10.1371/journal.pone.0339113

Published: December 17, 2025

Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.