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Open Access

Retraction

Retraction: Genistein Improves 3-NPA-Induced Memory Impairment in Ovariectomized Rats: Impact of Its Antioxidant, Anti-Inflammatory and Acetylcholinesterase Modulatory Properties

  • The PLOS One Editors

Following the publication of this article [1], concerns were raised for Figs 3, 6, 7, 8 and 9. Specifically, there are regions within the following figure panels which appear similar:

  • Fig 3F, 3G
  • Fig 6A, 6B, 6D, 6E, 6F, 6G
  • Fig 7D, 7E
  • Fig 8A, 8B, 8C, 8D, 8E, 8F
  • Fig 9A, 9B, 9D, 9G

In light of the above concerns that question the reliability and integrity of these results, the PLOS One Editors retract this article. In addition, results presented in Fig 3 of this article [1] appear similar to results presented in Fig 5 of [2, retracted in 3], published later by the same researchers. All authors either did not respond directly or could not be reached.

References

  1. 1. Menze ET, Esmat A, Tadros MG, Abdel-Naim AB, Khalifa AE (2015) RETRACTED: Genistein Improves 3-NPA-Induced Memory Impairment in Ovariectomized Rats: Impact of Its Antioxidant, Anti-Inflammatory and Acetylcholinesterase Modulatory Properties. PLoS ONE 10(2): e0117223.
  2. 2. Menze ET, Esmat A, Tadros MG, Khalifa AE, Abdel-Naim AB. (2016) Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum. Neuropharmacology, 105:35–46.
  3. 3. Menze ET, Esmat A, Tadros MG, Khalifa AE, Abdel-Naim AB. (2024) Retraction Notice to “Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum” [Neuropharm. 105 (2016) 35–46]. Retraction in: Neuropharmacology, 2024 Jul 1;252:109964.

Citation: The PLOS One Editors (2025) Retraction: Genistein Improves 3-NPA-Induced Memory Impairment in Ovariectomized Rats: Impact of Its Antioxidant, Anti-Inflammatory and Acetylcholinesterase Modulatory Properties. PLoS One 20(11): e0336073. https://doi.org/10.1371/journal.pone.0336073

Published: November 5, 2025

Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.