Figures
After the publication of this article [1] several typographical and data entry errors were identified. A member of the PLOS One Editorial Board assessed the following updates and confirmed that they did not impact the conclusions of [1].
The meta-analysis of coagulation parameters depicted in Fig 3A incorrectly included [2], which did not use the same measurement unit as the other included studies. Please see the correct Fig 3 here with [2] removed from the meta-analysis. Additionally, the second paragraph of the Coagulation Parameters section of the Mortality Outcomes section of the Results is corrected to: “Six studies evaluated the association between PT and mortality at the 7-day and 6-month endpoints in SICH patients. Meta-analysis results indicated that the differences in PT levels between non-surviving and surviving SICH patients were not statistically significant at 7-day (MD -0.12 [-0.52, 0.28], z = 0.59, p = 0.56; I2 = 37%, p = 0.19) or at 6-month (MD 0.11 [-0.38, 0.59], z = 0.43, p = 0.67; I² = 44%, p = 0.17) time points (Fig 3A).” This does not impact the interpretation of the analysis.
There are errors in the reporting of several statistical analyses in the results due to data entry and typographical errors. The following corrections are made:
- The first paragraph of the Blood counts section of the Mortality outcomes section of the Results is updated to: “A meta-analysis of 23 studies revealed significantly higher baseline white blood cells (WBC) counts in non-surviving SICH patients at all evaluated time points, including 7-day (MD 1.61 [0.61, 2.61], z = 3.15, p = 0.002; I2 = 39%, p = 0.13), 30-day (MD 2.49 [2.12, 2.87], z = 13.07, p < 0.00001; I2 = 16%, p = 0.31), 3-month (MD 1.13 [0.23, 2.03], z = 2.46, p = 0.01; I2 = 85%, p < 0.00001), and 6-month (MD 1.57 [0.12, 3.01], z = 2.12, p = 0.03; I2 = 77%, p = 0.002). (Fig 4A).”
- The first sentence of the fifth paragraph of the Coagulation parameters section of the Functional outcome section of the Results is updated to: “In contrast, meta-analyses of nine studies evaluating D-dimer levels showed that SICH patients with good functional outcome had significantly lower D-dimer levels compared to those with poor outcome at both the 3-month (MD -0.54 [-0.86, -0.21], z = 3.25, p = 0.001; I² = 73%, p = 0.005) and 6-month (MD -2.23 [-3.02, -1.45], z = 5.57, p < 0.00001; I² = 0%, p = 0.90) evaluation endpoints (Fig 8E).”
- The sixth paragraph of the Blood counts section of the Functional outcome section of the Results is updated to: “Last, meta-analyses of 18 studies showed no significant differences on platelet counts between patients with good and poor functional outcome at the 3-month (MD -1.60 [-7.55, 4.35], z = 0.53, p = 0.60; I2 = 64%, p = 0.0002) and 6-month (MD 4.16 [-1.84, 10.16], z = 1.36, p = 0.17; I2 = 0%, p = 0.71) evaluation endpoints (Fig 9F). The certainty of evidence were very low, with small effect sizes.”
There were no errors in the reporting of the above analyses in the figures included in [1], however, panel F was not originally included in Fig 9, and the updated figure can be found here.
The effect of VEGF on 3-month functional outcomes, reported in Fig 6B, were incorrectly interpreted. The second paragraph of the Angiogenic factors section of the Functional outcome section of the Results is updated to: “A meta-analysis of two studies revealed statistically significant differences in vascular endothelial growth factor (VEGF) levels between patients with good and poor functional outcome at the 3-month evaluation time (MD 62.11 [9.24, 114.98], z = 2.30, p = 0.02; I2 = 0%, p = 0.99) (Fig 6B). Nevertheless, the certainty of evidence was low, and the effect size was small.”
In the fifth line of the 17th paragraph of the Discussion, the interpretation of the meta-analysis of white blood cells was reported incorrectly, and is updated to: “In support of the meta-analysis findings on inflammatory biomarkers, the meta-analysis on WBC revealed that WBC counts are higher in SICH patients with poor outcomes.”
Due to the suboptimal quality of Figs 4, 5, 8 and 10 affecting readability in [1], the updated figures can be found here with improved resolution.
The authors apologize for the errors in the published article.
References
- 1. Sasongko AB, Perdana Wahjoepramono PO, Halim D, Aviani JK, Adam A, Tsai YT, et al. Potential blood biomarkers that can be used as prognosticators of spontaneous intracerebral hemorrhage: A systematic review and meta-analysis. PLoS One. 2025;20(2):e0315333. pmid:39970158
- 2. Delgado P, Alvarez-Sabín J, Abilleira S, Santamarina E, Purroy F, Arenillas JF, et al. Plasma d-dimer predicts poor outcome after acute intracerebral hemorrhage. Neurology. 2006;67(1):94–8. pmid:16832084
Citation: Sasongko AB, Perdana Wahjoepramono PO, Halim D, Aviani JK, Adam A, Tsai YT, et al. (2025) Correction: Potential blood biomarkers that can be used as prognosticators of spontaneous intracerebral hemorrhage: A systematic review and meta-analysis. PLoS One 20(9): e0332555. https://doi.org/10.1371/journal.pone.0332555
Published: September 17, 2025
Copyright: © 2025 Sasongko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.