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Open Access

Retraction

Retraction: The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6

  • The PLOS One Editors

After this article [1] was published, concerns were raised about Figs 1 and 2.

Specifically, when levels are adjusted to visualize the background:

  • The following lanes appear similar:
    • In Fig 1A, lanes 2-3 of the E6 - IP: E6 panel and lanes 2-3 of the ING4 - IP: E6 panel.
    • In Fig 1B, lanes 2 and 4 of the ING4 panel.
    • In Fig 1B, lane 3 of the ING4 panel, and in Fig 1C, lane 2 of the E6 panel, when flipped horizontally.
    • In Fig 1B, lanes 2 and 4 of the ING4 panel, and in Fig 1C, lane 3 of the E6 panel, when flipped horizontally.
    • In Fig 1D, lanes 3 and 6 of the E6 panel.
    • In Fig 2D, the Caski shE6 and CasKi shC panels and Fig 2A of [2], despite representing different cell transfections.
  • There appear to be vertical discontinuities in the following panels:
    • In Fig 1B, in the E6 and ING4 panels.
    • In Fig 1C, in the E6 panel.
    • In Fig 1D, in the E6 panel.
  • There appear to be multiple regions of similarity, and/or regions which are discontinuous with adjacent areas, in the backgrounds of the following panels:
    • In Fig 1C, in lanes 2 and 3 of the Coomassie panel.
    • In Fig 1D, in lane 2 of the ING4 panel.
    • In Fig 2B, in lane 5 of the ING4 panel.
    • In Fig 2B, in lane 5 of the Flag-E6 panel.

The authors did not respond to PLOS’ requests for comment or original data underlying the figures of concern.

In light of the above unresolved concerns, the PLOS One Editors retract this article.

All authors either did not respond directly or could not be reached.

References

  1. 1. Guo Y, Meng X, Wang Q, Wang Y, Shang H. The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. PLoS One. 2013;8(8):e71453. pmid:23967213
  2. 2. Guo Y, Meng X, Ma J, Zheng Y, Wang Q, Wang Y, et al. Human papillomavirus 16 E6 contributes HIF-1α induced Warburg effect by attenuating the VHL-HIF-1α interaction. Int J Mol Sci. 2014;15(5):7974–86. pmid:24810689

Citation: The PLOS One Editors (2025) Retraction: The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. PLoS One 20(9): e0331481. https://doi.org/10.1371/journal.pone.0331481

Published: September 3, 2025

Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.