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Open Access

Retraction

Retraction: Chemopreventive efficacy of Andrographis paniculata on Azoxymethane-induced aberrant colon crypt foci In Vivo

  • The PLOS One Editors

After the publication and correction of this article [1,2], concerns were raised regarding results presented in Figs 4–6, and Tables 1–3 and 5.

Specifically,

  • The Fig 4E panel in [1] and the Fig S1C panel in [3, retracted in 4] appear to partially overlap
  • The following panels appear similar:
    • Fig 5A in [1] and Fig 3a panel A in [5]
    • Fig 5B in [1] and Fig 1B in [3, retracted in 4]
    • Fig 5C in [1] and Fig 5A in [6]
    • Fig 6E in [1] and Fig 5a panel D in [5] when rotated 180°
  • There appear to be overlaps in some of the values in the following tables. It is unclear whether these results represent data obtained from the same or different conditions.
    • Table 1 in [1] and Table 2 in [5]
    • Table 2 in [1] and Table 3 in [5]
    • Table 3 in [1] and Table 4 in [5]
    • Table 5 in [1] and Table 1 in [5]

The corresponding author stated that they were unable to retrieve the original data underlying the results of this study. In light of the above concerns that question the reliability of the reported results and conclusions, the PLOS One Editors retract this article.

NAH, RPYY, SI, WN, SAMK, and HES either did not respond directly or could not be reached. MAA did not respond to the final editorial decision.

References

  1. 1. Al-Henhena N, Ying RPY, Ismail S, Najm W, Khalifa SAM, El-Seedi H, et al. Chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon crypt foci in vivo. PLoS One. 2014;9(11):e111118. pmid:25390042
  2. 2. PLOS ONE Staff. Correction: chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon Crypt Foci in vivo. PLoS One. 2015;10(4):e0119354. pmid:25848945
  3. 3. Hajrezaie M, Hassandarvish P, Moghadamtousi SZ, Gwaram NS, Golbabapour S, Najihussien A, et al. Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats. PLoS One. 2014;9(3):e91246. pmid:24618844
  4. 4. PLOS One Editors. Retraction: Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats. PLoS ONE. 2025;20(7):e0328986.
  5. 5. Al-Henhena N, Khalifa SAM, Ying RPY, Hassandarvish P, Rouhollahi E, Al-Wajeeh NS, et al. Chemopreventive effects of Strobilanthes crispus leaf extract on azoxymethane-induced aberrant crypt foci in rat colon. Sci Rep. 2015;5:13312. pmid:26307342
  6. 6. Almagrami AA, Alshawsh MA, Saif-Ali R, Shwter A, Salem SD, Abdulla MA. Evaluation of chemopreventive effects of Acanthus ilicifolius against azoxymethane-induced aberrant Crypt Foci in the rat colon. PLoS One. 2014;9(5):e96004. pmid:24819728

Citation: The PLOS One Editors (2025) Retraction: Chemopreventive efficacy of Andrographis paniculata on Azoxymethane-induced aberrant colon crypt foci In Vivo. PLoS One 20(7): e0328989. https://doi.org/10.1371/journal.pone.0328989

Published: July 28, 2025

Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.