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Open Access

Retraction

Retraction: Chemopreventive Evaluation of a Schiff Base Derived Copper (II) Complex against Azoxymethane-Induced Colorectal Cancer in Rats

  • The PLOS One Editors

After this article [1] was published, concerns were raised regarding results presented in Figs 1 and S1.

Specifically:

  • The following panels appear to partially overlap:
    • Fig 1D in [1] and Fig 5B in [2]
    • Fig S1C in [1] and Fig 4E in [3, corrected in 4 and retracted in 5]
  • Fig 1B in [1] appears similar to Fig 5B in [3, corrected in 4 and retracted in 5]

In response to the above concerns, a co-author and the corresponding author stated that they were unable to retrieve the original data underlying the results in this study, and the co-author requested retraction of the article.

In light of the above concerns which question the reliability of the reported results and conclusions, the PLOS One Editors retract this article.

SZM and NAM agreed with the retraction. NAM apologized for the issues with the published article. MAA did not respond to the final editorial decision. MH, PH, NSG, SG, ANH, AAA, MZ, ER, HK, SF, BK, and HMA either did not respond directly or could not be reached.

References

  1. 1. Hajrezaie M, Hassandarvish P, Moghadamtousi SZ, Gwaram NS, Golbabapour S, Najihussien A, et al. Chemopreventive Evaluation of a Schiff Base Derived Copper (II) Complex Against Azoxymethane-Induced Colorectal Cancer in Rats. PLoS ONE. 2014;9(3):e91246. pmid:24618844
  2. 2. Almagrami AA, Alshawsh MA, Saif-Ali R, Shwter A, Salem SD, Abdulla MA. Evaluation of Chemopreventive Effects of Acanthus ilicifolius against Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon. PLoS ONE. 2014;9(5):e96004. pmid:24819728
  3. 3. Al-Henhena N, Ying RPY, Ismail S, Najm W, Khalifa SAM, El-Seedi H, et al. Chemopreventive Efficacy of Andrographis paniculata on Azoxymethane-Induced Aberrant Colon Crypt Foci In Vivo. PLoS ONE. 2014;9(11):e111118. pmid:25390042
  4. 4. The PLOS ONE Staff. Correction: Chemopreventive Efficacy of Andrographis paniculata on Azoxymethane-Induced Aberrant Colon Crypt Foci In Vivo. PLoS ONE. 2015;10(4): e0119354.
  5. 5. The PLOS One Editors. Retraction: Chemopreventive Efficacy of Andrographis paniculata on Azoxymethane-Induced Aberrant Colon Crypt Foci In Vivo. PLoS ONE. 2025;20(7): e0328989.

Citation: The PLOS One Editors (2025) Retraction: Chemopreventive Evaluation of a Schiff Base Derived Copper (II) Complex against Azoxymethane-Induced Colorectal Cancer in Rats. PLoS One 20(7): e0328986. https://doi.org/10.1371/journal.pone.0328986

Published: July 28, 2025

Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.