Following the publication of this article, concerns were raised with results presented in Figs 2–7. Specifically,
- The following panels appear similar:
- Bands in the following lanes appear more similar than would be expected from independent results:
- Fig 2B actin lanes 1-2 and Fig 2B actin lanes 3-4
- Each Fig 3B actin lane,
- Fig 7C cyclin A lane 1 and Fig 7C lane 1,
- Fig 7C cyclin A lane 2 and Fig 7C lane 4 when flipped horizontally,
- Fig 7C cyclin A lane 4 and Fig 7C lane 3 when flipped horizontally,
- Fig 7C cyclin D1 lanes 1-2 and Fig 7C actin lanes 3-4
- When adjusting the colour levels to visualize the background, there appear to be irregularities in the background of the following panels:
- Fig 2B CDK2
- Fig 3B cyclin B1
- Fig 3B CDK4
- Fig 4B actin
- Fig 5C CDK4
- Fig 6C cyclin D1
- Fig 7C cyclin B1
- Fig 7C CDK4
In response to these concerns, author JC stated that they did not consent to being included as an author and requested retraction of the article,
In light of the above unresolved concerns that question the reliability and integrity of these results, the PLOS One editors retract this article.
JC agreed with the retraction. PW, SH, FW, YR, MH, and XW either did not respond directly or could not be reached.
References
- 1. Wang P, Huang S, Wang F, Ren Y, Hehir M, Wang X, et al. Cyclic AMP-response element regulated cell cycle arrests in cancer cells. PLoS One. 2013;8(6):e65661. pmid:23840351
- 2. Patel R, Gao M, Ahmad I, Fleming J, Singh LB, Rai TS, et al. Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. J Clin Invest. 2013;123(3):1157–75. pmid:23434594
Citation: The PLOS One Editors (2025) Retraction: Cyclic AMP-response element regulated cell cycle arrests in cancer cells. PLoS One 20(7): e0328370. https://doi.org/10.1371/journal.pone.0328370
Published: July 17, 2025
Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.