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Open Access

Retraction

Retraction: Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway

  • The PLOS One Editors

After this article [1] was published, concerns were raised regarding Figs 2–8.

Specifically, there appears to be partial or full overlap between the following panels:

  • The Invasion (48 h) - LoVo panel in Fig 2C and the Invasion (48 h) - over/MALAT1 panel in Fig 4B.
  • The Invasion (48 h) - LoVo panel of Fig 4B, the Invasion (48 h) - Vector panel of Fig 4B and the Invasion (48 h) - over/MALAT1 panel in Fig 6A.
  • The Migration (24 h) - LoVo panel in Fig 4B and the Migration (24 h) - over/MALAT1 panel in Fig 6A.
  • The β-actin panels in Figs 3A and 3B.
  • The β-actin panels in Figs 5A and 5B.
  • Lanes 2–3 of the MMP-7 panel in Fig 5B and lanes 1–2 of the β-catenin (Nuclear) – shRNA/MALAT1 panel in Fig 7B.
  • The Invasion (48 h) - vector and Invasion (48 h) - over/MALAT1 panels in Fig 8E, when flipped horizontally.
  • The upper panels in Fig 7A in [1] and the lower panels of Fig 4E in [2] (retracted in [3]).
  • The lower panels in Fig 7A in [1] and the upper panels of Fig 4E in [2] (retracted in [3]).

The first author stated that errors were made during the preparation of Figs 2C, 4B and 6A and provided what is stated to be the available original image and quantitative data underlying all figures in [1], and updated versions of Figs 4B and 6A. However, both the underlying image data and the updated figures provided raised further concerns about image integrity.

Regarding Figs 3 and 5, the first author stated that the same internal reference bands (β-actin) were presented in each figure because the original experiments were performed simultaneously with the same internal reference.

During editorial follow-up on another PLOS One article [4], the first author of [4] provided underlying images for Fig 2E of [4]. PLOS identified what appears to be partial and full panel overlap between that set of underlying data and panels in Figs 2C, 4B and 6A of [1].

Given the nature and extent of the above unresolved concerns which bring the reliability and integrity of the results and conclusions into question, the PLOS One Editors retract articles [1] and [4]. The Retraction notice for [4] can be found in [5].

QJ agreed with the retraction. XL, XF, LZhang, HS, LZhou, JS, JC, JQ, JR, and QL either did not respond directly or could not be reached.

References

  1. 1. Ji Q, Liu X, Fu X, Zhang L, Sui H, Zhou L, et al. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One. 2013;8(11):e78700. pmid:24244343
  2. 2. Chen F, Qi S, Zhang X, Wu J, Yang X, Wang R. lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma. Int J Oncol. 2019;54(4):1183–94. pmid:30720068
  3. 3. Chen F, Qi S, Zhang X, Wu J, Yang X, Wang R. [Retracted] lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma. Int J Oncol. 2025;66(5):37. pmid:40183411
  4. 4. Liu X, Ji Q, Ye N, Sui H, Zhou L, Zhu H, et al. Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway. PLoS One. 2015;10(5):e0123478. pmid:25954974
  5. 5. The PLOS One Editors. Retraction: Berberine inhibits invasion and metastasis of colorectal cancer cells via COX-2/PGE2 mediated JAK2/STAT3 signaling pathway. PLoS ONE. 2025;20(7):e0328009.

Citation: The PLOS One Editors (2025) Retraction: Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One 20(7): e0328012. https://doi.org/10.1371/journal.pone.0328012

Published: July 14, 2025

Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.