After this article [1] was published, concerns were raised regarding results presented in Figures 1, 2, 3, 7, 8, 9, 10, and 11.

Specifically:

• There appears to be vertical and horizontal discontinuities in the background surrounding lanes of the following panels:
  • Figure 2A SIRT3
  • Figure 7A β-actin
  • Figure 8A β-actin
• There appears to be similarities between lanes within the following panels:
  • Figure 1A: SIRT1, FOXO3A, FOXO1, and β-actin
  • Figure 2A: SIRT4
  • Figure 3A: bax, bcl-2, and β-actin
  • Figure 7A: TIM50 (mitochondria)
  • Figure 9A: bax (mitochondria), bax (cytosol), and bcl-2 (cytosol)
  • Figure 10A: SIRT1, SIRT3, and β-actin
  • Figure 11A: FOXO3A and FOXO1
• The following results appear more similar than would be expected from independent results:
  • Figure 1A SIRT1 lanes 1, 2, and 7 of [1] and Figure 4B bax lanes 1, 2, and 7 of [2] respectively
  • Figure 1A FOXO3A lanes 2-6 of [1] and Figure 4B p27 lanes 2-6 of [2] respectively
  • Figure 1A FOXO1 lanes 1-4 of [1] and Figure 4B CDK-2 lanes 2-5 of [2] respectively
  • Figure 1A FOXO1 lane 6 of [1], Figure 1A FOXO1 lane 7 of [1], and Figure 4B CDK-2 lane 7 of [2]
  • Figure 1A β-actin lanes 1-3 and 6-7 of [1] and Figure 4B β-actin lanes 1-3 and 5-6 of [2] respectively
  • Figure 1A β-actin lane 4 of [1], Figure 1A β-actin lane 5 of [1], and Figure 4B β-actin lane 4 of [2]

The authors’ responses did not resolve the concerns with this article.

In light of the above concerns that question the integrity and reliability of the reported results and conclusions, the PLOS One Editors retract this article.

All authors did not respond to the final editorial decision.

The Figure 1A results report material that appears similar to results previously reported in [2] published in 2006 by The American Society of Hematology, which is not offered under a CC BY license. Due to restrictions that apply to the original article’s license, Figure 1A is excluded from the PLOS article’s [1] CC BY 4.0 license.