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Open Access

Correction

Correction: High prevalence of p16 staining in malignant tumors

  • Noémi De Wispelaere,
  • Sebastian Dwertmann Rico,
  • Marcus Bauer,
  • Andreas M. Luebke,
  • Martina Kluth,
  • Franziska Büscheck,
  • Claudia Hube-Magg,
  • Doris Höflmayer,
  • Natalia Gorbokon,
  • Sören Weidemann,
  • Katharina Möller,
  • Christoph Fraune,
  • Christian Bernreuther,
  • Ronald Simon,
  • Christian Kähler,
  • Anne Menz,
  • Andrea Hinsch,
  • Frank Jacobsen,
  • Patrick Lebok,
  • Till Clauditz,
  • Guido Sauter,
  • Ria Uhlig,
  • Waldemar Wilczak,
  • Stefan Steurer,
  • Eike Burandt,
  • Rainer Krech,
  • David Dum,
  • Till Krech,
  • Andreas Marx,
  •  [ ... ],
  • Sarah Minner
  • [ view all ]
  • [ view less ]

In Table 1, there are errors in the values indicated to the columns of p16 immunostaining of rows “Non-invasive papillary urothelial carcinoma, pTa G2 low grade”, “Non-invasive papillary urothelial carcinoma, pTa G2 high grade” and “Non-invasive papillary urothelial carcinoma, pTa G3” under the category of Tumors of the urinary system. Also, the “(neg. = negative, mod. = moderate, pos. = positive).” is missing from its caption. Please see the correct Table 1 and its complete caption here.

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Table 1. p16 immunostaining in human tumors (neg. = negative, mod. = moderate, pos. = positive).

https://doi.org/10.1371/journal.pone.0318271.t001

In the S2 Table, the values in the rows “Non-invasive papillary urothelial carcinoma, pTa G2 low grade”, “Non-invasive papillary urothelial carcinoma, pTa G2 high grade” and Non-invasive papillary urothelial carcinoma, pTa G3 of the organ urinary system are incorrect. The authors have provided the correct version of S2 Table here.

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S2 Table. p16 positive and p16 negative normal tissues and associated tumor types.

https://doi.org/10.1371/journal.pone.0318271.t002

In Figs 3 and 4, the ranking order of tumor types is incorrect. Please see the correct Figs 3 and 4 here.

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Fig 3. Ranking order of p16 immunostaining in human tumors.

Both the frequency of positive cases (blue dots) and the frequency of strongly positive cases (orange dots) is shown.

https://doi.org/10.1371/journal.pone.0318271.g001

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Fig 5. Graphical representation of p16 data from this study (marked with a cross) in comparison with data from existing literature (marked with dots).

In order to simplify the figure the percentage of weak, moderate and strong staining was merged. Red dots are used for previous studies involving 1–9 cases, yellow dots for studies involving 10–50 cases and green dots for studies involving >50 cases. All studies are quoted in a list of references in S1 Table.

https://doi.org/10.1371/journal.pone.0318271.g002

There is an error in fourth sentence of the Abstract section. The correct sentence is: In cancer, highest positivity rates were observed in uterine cervix squamous cell carcinomas (94.4%), Merkel cell carcinoma (97.7%), and small cell carcinomas of various sites of origin (54.5%-100%).

Reference

  1. 1. De Wispelaere N, Rico SD, Bauer M, Luebke AM, Kluth M, Büscheck F, et al. (2022) High prevalence of p16 staining in malignant tumors. PLOS ONE 17(7): e0262877. pmid:35862385

Citation: De Wispelaere N, Rico SD, Bauer M, Luebke AM, Kluth M, Büscheck F, et al. (2025) Correction: High prevalence of p16 staining in malignant tumors. PLoS ONE 20(1): e0318271. https://doi.org/10.1371/journal.pone.0318271

Published: January 24, 2025

Copyright: © 2025 De Wispelaere et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.