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Open Access

Correction

Correction: Roles of PI3K/Akt and c-Jun Signaling Pathways in Human Papillomavirus Type 16 Oncoprotein-Induced HIF-1α, VEGF, and IL-8 Expression and In Vitro Angiogenesis in Non-Small Cell Lung Cancer Cells

  • Erying Zhang,
  • Xiaowei Feng,
  • Fei Liu,
  • Peihua Zhang,
  • Jie Liang,
  • Xudong Tang

In Fig 2D, the image of 16 E6 is incorrect. Please see the correct Fig 2 here.

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Fig 2. Effect of LY294002 on HPV-16 E6-induced HIF-1α, VEGF, and IL-8 expression and in vitro angiogenesis in NSCLC cells.

HPV-16 E6-transfected NSCLC cells were pretreated for 24 h with different concentrations of LY294002. (A) HIF-1α and p-Akt protein levels in transfected NSCLC cells (Left: A549, Right: NCI-H460) were analyzed by Western blotting. (B) VEGF and IL-8 protein concentration in the conditioned media derived from transfected A549 cells was determined by ELISA. (C) VEGF and IL-8 mRNA levels in transfected A549 cells were determined by real-time PCR. (D) HUVECs (5×103 cells/well) were seeded onto the surface of 96-well cell culture plates pre-coated with polymerized ECMatrix and then incubated at 37°C for 6 to 8 h in the conditioned media derived from HPV-16 E6-transfected A549 cells in the absence or presence of LY294002. Left: The tube formation was observed under a phase-contrast microscope (20×). Right: The total tube length in three random view-fields per well was by Scion image software measured and average value was calculated. All data are expressed as mean ± SD of three independent experiments. *P<0.05,**P<0.01.

https://doi.org/10.1371/journal.pone.0314378.g001

Reference

  1. 1. Zhang E, Feng X, Liu F, Zhang P, Liang J, Tang X (2014) Roles of PI3K/Akt and c-Jun Signaling Pathways in Human Papillomavirus Type 16 Oncoprotein-Induced HIF-1α, VEGF, and IL-8 Expression and In Vitro Angiogenesis in Non-Small Cell Lung Cancer Cells. PLOS ONE 9(7): e103440. pmid:25058399

Citation: Zhang E, Feng X, Liu F, Zhang P, Liang J, Tang X (2024) Correction: Roles of PI3K/Akt and c-Jun Signaling Pathways in Human Papillomavirus Type 16 Oncoprotein-Induced HIF-1α, VEGF, and IL-8 Expression and In Vitro Angiogenesis in Non-Small Cell Lung Cancer Cells. PLoS ONE 19(11): e0314378. https://doi.org/10.1371/journal.pone.0314378

Published: November 20, 2024

Copyright: © 2024 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.