Figures
Abstract
Introduction
Prostate cancer is often treated with radical prostatectomy, but surgery can leave patients with side effects. Patients who actively take part in their rehabilitation have been shown to achieve better clinical outcomes. eHealth support has the potential to increase patient activation, but has rarely been evaluated in long-term randomized controlled trials. Therefore, we evaluated the effects on patient activation of eHealth support (electronic Patient Activation in Treatment at Home, ePATH) based on motivational theory. The aim was to investigate the effects of eHealth support on patient activation at 6 and 12 months after radical prostatectomy, compared with standard care alone, and associations with baseline patient activation and depression.
Methods
A multicentre randomized controlled trial with two study arms was conducted. Men planned for radical prostatectomy at three county hospitals in southern Sweden were included and randomized to the intervention or control group. The effects of ePATH on the secondary outcome, patient activation, were evaluated for one year after surgery using the patient activation measure and analysed using a linear mixed model.
Results
The study included 170 men during 2018–2019. In the intervention group, 64% (53/83) used ePATH. The linear mixed model showed no significant differences between groups in patient activation [β -2.32, P .39; CI -7.64–3.00]. Baseline patient activation [β 0.65, P < .001; CI 0.40–0.91] and depression [β -0.86, P .03; CI -1.64– -0.07] statistically impacted patient activation scores over one year.
Conclusions
ePATH had no impact on patient activation during long-term prostate cancer rehabilitation. However, patient activation at baseline and depression scores significantly influenced patient activation, underlining the need to assess these aspects in prostate cancer surgery rehabilitation.
Trial registration
ISRCTN Registry ISRCTN18055968, (07/06/2018); https://www.isrctn.com/ISRCTN18055968; International Registered Report Identifier: RR2-10.2196/11625.
Citation: Wennerberg C, Ekstedt M, Schildmeijer K, Hellström A (2024) Effects on patient activation of eHealth support in addition to standard care in patients after radical prostatectomy: Analysis of secondary outcome from a randomized controlled trial. PLoS ONE 19(9): e0308555. https://doi.org/10.1371/journal.pone.0308555
Editor: Rabie Adel El Arab, Almoosa College of Health Sciences, SAUDI ARABIA
Received: February 9, 2024; Accepted: July 23, 2024; Published: September 10, 2024
Copyright: © 2024 Wennerberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: The General Data Protection Regulation (GDPR) applies as law for all EU Member countries. All processing of personal data must adhere to the fundamental principles, as indicated in the General Data Protection Regulation. Personal data must always be handled in a secure manner. Even if those processing the data do not know, or are able to identify the person in question, this may be considered as the processing of personal data. In the ethics approval, participating persons are ensured that data will only be handled by the research team. Due to the GDPR and the information given to study participants, data cannot be available openly, but rather on request. Inquiries about data files could be made by contacting dataskyddsombud@lnu.se. It should also be noted that some information in the data file is currently in Swedish and may need to be prepared before sharing.
Funding: Funding for the study, with no involvement in study design, data collection, analysis, or interpretation of data, writing manuscript or decision to publish were provided by: the Kamprad Family Foundation for Entrepreneurship, Research & Charity (No 20150067, ME) www.familjenkampradsstiftelse.se, the Swedish Cancer Society (CAN 2017/748, ME) www.cancerfonden.se, the Research Council of Southeast Sweden (FORSS-657211, 760131, ME) www.researchweb.org/is/forss, the Cancer Foundation in Kalmar County www.cancerstiftelsen-kalmar.se (ME), and Region Kalmar County www.regionkalmar.se (CW).
Competing interests: The authors have declare that no competing interests exist.
List of abbreviations: ePATH, electronic Patient Activation in Treatment at Home; EPIC, Expanded Prostate cancer Index Composite; RCT, Randomized Control Trial; PAM, Patient Activation Measure; SF, Short Form Health Survey; PHQ, Patient Health Questionnaire; SD, Standard Deviation; SEK, Swedish Crown; CI, Confidence Interval
Introduction
Prostate cancer is one of the most common malignancies in the male genitourinary system. The Global Cancer Statistical Report by WHO, shows that there were about 1 400 000 new cases of prostate cancer worldwide in 2020, accounting for over 7% of malignancies. The incidence rate ranking third highest after breast and lung cancer worldwide, and eighth in mortality rate [1]. Treatments for prostate cancer increase the chance of survival but can lead to side effects such as life-long urinary incontinence, affected bowel habits, pain, and sexual dysfunction, significantly impacting health-related quality of life [2]. Being diagnosed with cancer may also impact psychological well-being, and depression is more prevalent in patients with cancer than in the general population [3–5].
There is a growing awareness of the importance of patients having an active role in the management of their health and care, and the complex challenge of achieving that [6, 7]. Patient activation implies taking responsibility for managing symptoms, adhering to treatment regimens, and adopting new behaviours to reduce risks of complications [8]. However, standardized information routines often overlook assessing patients’ knowledge, skills and competence in actively managing their health and care [9–11].
Assessing patient activation informs strategies for supporting patients with varying capabilities in self-care. Patients range from being passive with poor adherence to recommendations to those who have changed their lifestyle, but struggle with maintaining these changes. With appropriate assessment and support, patients can improve their activation or maintain a high level [11, 12]. Patients with higher patient activation are more likely to understand their diagnosis, cope with side effects, adhere to treatment recommendations, adopt a healthy lifestyle, being satisfied with care [11, 13], and achieve more favourable clinical outcomes [13, 14]. To promote motivation and achieve high levels of patient activation, it is essential to satisfy three basic psychological needs: competence, autonomy, and relatedness [15]. While, adequate support can fulfil patient´s motivational needs, motivation is intricate. It varies on a continuum from intrinsic motivation (self-supporting inner will) to external factors driven by rewards or punishments [16]. Motivation is also vulnerable to external influences including persistent depression during prostate cancer rehabilitation. These influences pose additional challenges in health management [17, 18] affecting treatment decisions, adherence to recommendations, and functional outcomes [3].
Motivational interventions, rooted in fulfilling basic needs for intrinsic motivation have proven effective in cancer rehabilitation [19] and positively impact health outcomes [20]. eHealth interventions hold significant potential for promoting patient activation by offering integrated, individualized services that enhance accessibility, efficiency and align with patient preferences and location [20, 21]. However, there is a lack of longitudinal clinical randomized controlled trials (RCT), investigating the effects of eHealth interventions [22]. In a recent systematic review of eHealth interventions for patient activation, lectures and self-reports were found helpful in rehabilitation [21]. However, requests for interventions throughout the entire care trajectory (not just the initial phases) were noted [23]. Most eHealth interventions primarily focus on clinical outcomes, neglecting the potential to enhance patient activation or to consider its complexity [24]. This study sought to meet this gap by assessing the effects of an eHealth intervention on patient activation during prostate cancer rehabilitation.
The aim was to investigate the effects of eHealth support on patient activation at 6 and 12 months after radical prostatectomy, compared with standard care alone, and explore associations with baseline patient activation and depression.
Methods
Study design
This study analyses data from a RCT, with two study arms. It compares the effects of an eHealth support, known as Patient Activation in Treatment at Home (ePATH), which provides additional assistance for patients to adhere to rehabilitation recommendations in the intervention group, against standard care alone in the control group. The study design has been described in detail in the study protocol [25] and in a previous report on primary outcomes [26]. The study is registered, as an International Standard Randomized Controlled Trial (18055968), International Registered Report Identifier (10.2196/11625) and follows CONSORT guidelines (S1 Checklist).
Ethics approval and consent to participate
The study was performed in accordance with principles in the Declaration of Helsinki and had ethical approval from the Regional Ethics Committee (Ref No 2016/484-31; 2017/512-32; 2018/147-32) in Sweden. All patients gave written informed consent to participate and were informed that data would be handled confidentially, and they could withdraw their consent at any time, without giving a reason.
Inclusion criteria and sample size
The inclusion criteria were: >18 years, elective radical prostatectomy, having a smartphone-based e-identification, and being able to communicate in Swedish. All men who met the inclusion criteria and accepted participation at any of three county hospitals in southern Sweden were included. An exclusion criterion was having a cognitive impairment (assessed by the cancer nurse specialist).
An independent statistician performed the sample size estimation based on the “The sample size and suggested end point” table of the primary outcome measure for the RCT, the Expanded Prostate Index Composite (EPIC). To show clinical importance, the effect size was set to 0.5, as recommended. A maximum of 4 domains of EPIC, with a two-tailed independent samples t-test per domain, a 5% overall significance level and a power of 80%, 91 patients per group had to be included. Considering a dropout of 25%, 114 patients per group was needed [26–28]. Sample size was not calculated for the secondary outcome measure, the Patient Activation Measure (PAM), on which the present study reports [25].
Setting and standard care
Three county hospitals in southern Sweden included patients planned for radical prostatectomy. The care organizations differed somewhat between the sites [25], but all clinics applied the national standardized care trajectory [9]. Men with prostate cancer are allocated a cancer nurse specialist, for easy access to healthcare and support. Generic recommendations for rehabilitation were provided verbally and in writing to both intervention and control groups. The cancer nurse specialists contacted the patients in conjunction with regular check-ups after surgery (usually at 3- or 6-month intervals) and provided individual consultation on rehabilitation and further treatment. Other contacts were on each patient’s initiative [9].
The ePATH intervention
ePATH consisted of a web-based and mobile application, to be used as additional support in cancer rehabilitation. The intervention is based on the self-determination theory, to satisfy the three basic psychological needs for motivation: competence, autonomy, and relatedness [15]. Competence was supported as patients could read/re-read individualized information, explanations, and instruction for self-care at any time. Patient autonomy was respected as they had the option to customize ePATH, and independently choose actions and when to perform them. Patients could register self-care activities performed, rate their symptoms, get notifications, set goals for themselves and see graphs of improvements over time. Relatedness was pursued through the simplified interaction with the cancer nurse specialist through ePATH’s messaging function. Links to patient associations were also provided [29].
Data collection and procedures
Recruitment.
Patients were recruited between 2018 (Jan 1) and 2019 (Dec 31), for the study length to be reasonable and data collection was finalized in 2021 (Jan 31). In conjunction with treatment decisions on radical prostatectomy, all men at the three sites got written information about the study and a manual for ePATH from their cancer nurse specialist. The cancer nurse specialists asked the patients about participation a week after the written information. A signed consent form was sent by post to the researchers. Every other week, the cancer nurse specialists were in contact with CW regarding patient inclusion, at which time participants were sent the baseline survey. All participants answered web surveys at baseline (2 weeks prior to surgery) and at 1, 3, 6, and 12 months [25] after their radical prostatectomy (two reminders/survey were sent by e-mail within 10 days). This study reports on the patient activation and depression scores, reported at baseline, 6 and 12 months post radical prostatectomy.
Randomization.
The trial was performed as a 1:1 randomization trial, with computer-generated block randomization lists created by an independent statistician. The allocation was revealed by opening sealed, numbered envelopes consecutively. ePATH accounts were set up (by CW) for the patients in the intervention group and the cancer nurse specialists adjusted the accounts based on each individual patient. All patients received an e-mail one week after the baseline questionnaires, revealing allocation. Thus, no blinding of patients, cancer specialist nurses or CW was possible. Both groups got standard care, and the intervention group additionally got access to ePATH for one year. They were free to use and adjust their accounts to suit individual preferences during this time.
Measures
The characteristics of participants obtained at baseline were age, marital status, household income, and education. Use of ePATH was based on data metrics after data collection was finalized. Self-rated general health was measured using a single item from the Short Form Health Survey (SF-36) (in general, how would you describe your overall health?) rated on a 5-point scale from 1 = excellent to 5 = poor [30, 31].
Motivation was measured using the short form of the Needs Satisfaction and Frustration scale [32], with three subscales, a patient’s perceived autonomy, social belonging, and own competence. The scale comprises 6 items (2 per subscale), with 7 response options ranging from very often (1) to very seldom (7). One of two items per subscale should be reversed before summarizing and divided by two, for the final score. A Swedish version of the scale has been validated in a general Swedish population [33].
The Patient Health Questionnaire 9 (PHQ-9) comprises 9 questions, measuring the severity of depression (as defined by the Diagnostic and Statistical Manual of Mental Disorders 4th edition), with a total score ranging from 0 to 27, and a cut-off score at 10. Higher scores indicate a higher degree of depression, with scores categorized on a five-level scale: minimal depression 1–4, mild depression 5–9, moderate depression 10–14, moderately severe depression 15–19, and severe depression 20–27. One item assesses suicide risk [34]. The PHQ-9 fulfils the criteria for sensitivity and specificity of instruments used to diagnose and grade depression severity [35]. The Swedish version has demonstrated good measurement properties in a primary care context and in a sample of psychiatric patients [36].
Patient activation was measured using the Patient Activation Measure (PAM-13), which aims to assess patient’s self-reported knowledge, skill, and confidence regarding management of own health and illness [12]. Patient activation is assessed by 13 items, that gauges a person’s self-concept as a manager of their own health and care. Each question has 5 response categories, ranging from strongly disagree (1) to strongly agree (4), with 0 corresponding to ‘not applicable’. A scoring sheet provided by the developer, Insignia Health, indicates the PAM scores (0–100) and correlating levels (1–4) of patient activation. Level 1: disengaged and overwhelmed; level 2: becoming aware, but still struggling; level 3: taking action; level 4: maintaining behaviours and pushing further. Each point change in the score is meaningful and a change of 3–4 points may be associated with the difference between being engaged and not. However, no cut-offs are available. Most individuals have activation scores between 30 and 90 [37]. The PAM-13 has shown good measurement properties regarding validity and reliability [12, 38] and the Swedish version has been validated in discharged medical patients, geriatric patients, and surgical patients [39].
Statistical analysis
Data were analysed using SPSS software (version 29; IBM Corp) for Windows [40]. Of the 170 patients included, five declined participation after randomization (remaining: 83 intervention and 82 control group). Patients without any data (n = 20) were considered lost to follow-up and excluded from final analyses, resulting in 145 patients (71 intervention and 74 control group) included in a modified intention-to-treat analysis (Fig 1) [26]. For an intention-to-treat analysis to be valid, its assumptions need to be valid; not all patients must be included in the analysis [41]. A missing data analysis showed randomly missing data at the individual level for approximately 15% of outcome measures, no outliers were removed. We therefore imputed data, using multiple imputations with predictive means matching [42]. Five imputation rounds were performed, and the pooled values of these imputations have been presented [43]. The pooled values and imputations were further compared with the original data for validity (S1 Table). All statistical tests employed a two-sided significance level of < .05. Descriptive statistics were used to describe participant characteristics and baseline data. Means and standard deviations were used for the normally distributed continuous variables (S2 Table). To identify differences between groups, Pearson’s chi-squared test was used for nominal variables, the Mann-Whitney U-test for ordinal variables, and the independent Student’s t-test for normally distributed continuous variables. Some response options for self-rated general health were merged– 1 (poor) and 2 (fair), and 4 (very good) and 5 (excellent), respectively–due to a small number of responses at the extremes, resulting in a 3-point scale. To investigate the mean PAM score differences over time between groups, a linear mixed model with repeated measures and an unstructured correlation structure was used. An interaction term between time and group was employed to identify differences in the pattern of change. The assumptions of the model were checked based on residuals and Akaike Information Criterion (AIC). The model was controlled for the effects of baseline PAM scores, PHQ scores, and age. To illuminate the time-varying covariance of the PHQ, we used mean PHQ scores to distinguish from changes in time.
170 men were included and both groups allocated 85 men. Five men withdrew participation. Men with no answers (19) were considered lost to follow-up.
Results
Participant characteristics, baseline data, and use
The mean age of participants in both groups at inclusion was 64 years (SD 6.2) and age ranged from 48 to 78 years. The participant characteristics did not statistically significantly differ between the groups as regards marital status (p = .82), household income (p = .51), or level of education (p = .74). In the intervention group 43% (36/83) were married/had a partner compared to 54% (44/82) in the control group. The largest proportion of participants had a monthly household income >45,000 Swedish crowns (intervention group 40%, 33/83; control group 39%, 32/82), and university education (intervention group 27%, 22/83; control group 29%, 24/82).
Baseline data (Table 1) on the motivational subscales ‘autonomy’ and ‘relatedness’ and depression were similar between groups. However, the intervention group had higher PAM scores and higher ratings on the motivational subscale ‘competence’ than those in the control group at baseline. The largest proportion of participants (in both groups) had minimal depression at baseline. Use of ePATH in the intervention group was defined as using ePATH more than once, and 64% of the intervention group fell into that category.
Changes in depression scores (PHQ-9)
The depression scores (PHQ-9 mean value) increased from 6 months to 12 months from minimal depression (mean 2.72 (SD 3.94)) to moderate depression (mean 12.92 (SD 4.11)) in both the intervention and control group. No statistically significant difference between groups was detected (6 months p = .69; 12 months p = .68).
Effects of ePATH on patient activation (Patient Activation Measure, PAM-13)
The linear mixed model did not detect any statistically significant differences in PAM score between the intervention and control groups at 6 or 12 months (Table 2). No statistically significant interaction between time and group was found. Higher PAM score at baseline (higher patient activation) was statistically significantly correlated with increased PAM score at 6 and 12 months. Higher PHQ score (higher levels of depression) was statistically significantly correlated with decreased PAM score (less patient activation) at 6 and 12 months. Age did not statistically significantly correlate with PAM score.
Both intervention and control groups had improved PAM scores between 6 months and 12 months (Table 3).
Discussion
The present study investigated the effects of eHealth support on patient activation at 6 and 12 months after radical prostatectomy, compared with standard care alone, and explored associations with baseline patient activation and depression. Our results did not show an increase in patient activation in the intervention group although ePATH was designed based on self-determination theory [15]. Hence, ePATH did not effectively promote patients’ active engagement in long-term prostate cancer rehabilitation. Notably, both the intervention and control groups exhibited high motivation and patient activation at baseline. Although the intervention group had slightly higher scores in patient activation and competence than the control group, it is possible that patients with already fulfilled motivation needs may not experience further improvements. High PAM scores could indicate that these patients possess the necessary skills and confidence to seek rendering additional support targeting motivational aspects unnecessary [13].
Our study shows that patients’ PAM scores at baseline significantly correlated with PAM scores at 6 and 12 months. Patients in both groups had high PAM scores at baseline and these were maintained over the year after surgery. Previous research indicates that when a behaviour is established at baseline, increase in patient activation correlates with sustained high levels of that behaviour over time [44]. However, ePATH, which broadly supports patient activation, did not differentiate interventions for highly activated versus less activated patients. Assessing patient activation at the beginning of a patient’s cancer trajectory can help identify those who require targeted support [45]. Healthcare professionals could need tools for tailoring support based on each patient’s capacity for activation [46].
The streamlined accessibility to the cancer nurse specialist in ePATH did not yield an impact on patient activation despite the possibility of increased engagement. Prior research [47], underscores that substantial interaction time with a care provider correlates with increased activation levels among prostate cancer patients. This suggests that strategies aimed at enhancing accessibility to healthcare professionals could be a promising approach for fostering patient activation. Nevertheless, our results did not support ePATH as such a tool. As the demand for cancer rehabilitation support grows and care structure evolves [1], enhancing patient activation might require re-evaluating the roles of patients and healthcare providers, involving both parties in utilizing eHealth tools, as their interaction significantly influences outcomes.
Depression (PHQ scores) negatively predicted patient activation, impacting self-management and adherence to rehabilitation recommendations, which is in line with previous research [48]. Prior research found that patients with higher patient activation correlated with lower depression scores over one year and that more activated patients showed greater engagement in healthy behaviours [49]. Further, psychological interventions in prostate cancer rehabilitation also improved depression scores [50–52]. Thus, to effectively address patient needs, supporting patient activation may require integrating the management of depression symptoms [49]. However, further research is needed to explore causal relationships and effective interventions for behaviour change and increased patient activation [5].
eHealth has the potential to improve patient activation through interventions [53] but is rarely incorporated into the healthcare system [54]. Patients are left to decide on their own, which applications might be useful for them. There is a need for further understanding of the mechanisms determining what works, under which circumstances, and for whom, to disseminate eHealth interventions in cancer rehabilitation [55, 56]. Future research should aim to assess not only the outcomes of eHealth interventions on patient activation, but also explore the specific mechanisms through which eHealth support can be beneficial. It is crucial to investigate which patient groups can benefit from eHealth interventions.
Strengths and limitations
The study’s power was calculated based on primary outcome measures in another study [26]. Recruitment of patients was terminated after two years, of concern of the involved clinics (workload) and for standard care to remain the same for all included participants. The current study therefore included 170 patients. Dropout can be a threat to validity, as it can introduce selection bias. An intention-to-treat analysis, where dropouts are assumed to have a neutral effect, is a way to avoid bias. However, such a procedure can diminish the power of a study [57]. eHealth interventions generally struggle with high dropout rates and one of the fundamental methodological issues in eHealth trials is that a substantial proportion of the intervention group will use the intervention sparingly or not at all [58]. The study was performed in routine clinical practice, to ensure minimal burden on the valuable time of the cancer nurse specialists and to show how this kind of intervention could work in contemporary clinical scenarios. This approach stems from the prevalent demand for clinical RCTs [22]. The frequency of use of ePATH [26] in the intervention group might have affected the results, as not all men used ePATH, even though they had gone through recruitment and given informed consent, thus agreeing to adopt the intervention [57]. Participants might have experienced dissonance between the intervention and their expectations, affecting attrition [59] or not perceived as creating benefits [57]. The procedure at inclusion might have influenced the use as well; incorporation of a hands-on introduction or choosing another time point might have increased use. Multiple factors affect how the findings can be generalized and eHealth support do not reach the total population. Further studies should focus on investigating which patients would gain from eHealth support for patient activation.
Applicability and validity should be considered in the evaluation. The study had a homogeneous sample of men after radical prostatectomy, which increases the generalizability of the findings. The sample had high PAM scores in general, which reflects the physiological capacity of this population. Further, that fact raises questions of selection bias and ceiling effects, causing difficulties in identifying statistical differences between groups. The use of linear mixed models with two assessment points improved the representability of the sample, as individuals without complete data could be included [60]. However, the use of imputations should be considered. An accepted method for imputation was used, which increases validity [61]. Valid results were seen when the imputed dataset was compared with the original dataset.
Patient activation is a complex outcome with heterogeneous variables and processes involved. The lack of conceptual clarity concerning patient empowerment, engagement, and activation, makes it challenging to operationalize interventions and measure all the aspects involved, influencing the eHealth context [62]. Although it appears that eHealth interventions can be effective, the interventions show a great heterogeneity of technologies, variables, and outcomes assessed [20]. The PAM offers an adequate measure to monitor patient activation [12] and is viewed as a successful way to measure patient activation [63], but can be arbitrary in nature [64]. In the present study, patients with elevated depression scores correspondingly showed diminished patient activation scores. This underscores the importance of illuminating the complex dimension of patient activation within the context of cancer rehabilitation. Moreover, it emphasises the need for a comprehensive approach where the evaluation and support of patients encompass both depression and patient activation in parallel throughout the rehabilitation process.
Conclusions
ePATH had no impact on patient activation during long-term prostate cancer rehabilitation. However, baseline patient activation levels and depression scores significantly influenced patient activation. This study underlines the need to assess patient activation preoperatively and identify depression in post-prostate cancer surgery rehabilitation.
Supporting information
S1 Table. Sensitivity analysis of original data and five imputation rounds.
https://doi.org/10.1371/journal.pone.0308555.s002
(XLSX)
S2 Table. Descriptive statistics of mean (SD) and median (IQR) of continuous outcome variables.
https://doi.org/10.1371/journal.pone.0308555.s003
(DOCX)
Acknowledgments
We thank the men who participated, the urological clinics, and the cancer nurse specialists who made this study possible. We also thank the statistician Magnus Backheden for contributing with his statistical expertise.
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