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Open Access

Retraction

Retraction: Long Non-Coding RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the Cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast Cancer Cells

  • The PLOS ONE Editors

Following the publication of this article [1], concerns were raised that images presented in Figs 2 and 4 appear similar to panels representing different experiments in articles [2–6] published by different author groups. Specifically:

  1. ○ Fig 2D LV-HOTAIRKD in [1] and Fig 4C Transwell miR-99a of [2].
  2. ○ Fig 2D LV-scrambled in [1], Fig 3B H1299-miR-NC of [2], and Fig 6B 24h MG63-DDP/vector of [3].
  3. ○ Fig 2D LV-HOTAIR in [1] and Fig 4C Transwell miR-NC of [2].
  4. ○ Fig 2D LV-vector in [1] and Fig 6A 0h MG63/vector of [3].
  5. ○ Fig 4C LV-vector in [1] and Fig10A SK-HEP-1 shCCDC88A/VEGF of [4].
  6. ○ Fig 4C LV-HOTAIR in [1] and Fig 1A SNU-449 CSCs Mock of [5, retracted in 6].
  7. ○ Fig 4C LV-HOTAIR/miR-34a mimics in [1] and Fig 10A SK-HEP-1 shScrambled of [4].
  8. ○ Fig 4C LV-HOTAIR/scrambled mimics in [1] and Fig 10A SK-HEP-1 Mock of [4].

First author JD responded stating that they collaborated with authors of [2] and [3] at the Analysis Testing Center of Chengdu University of Traditional Chinese Medicine, and suggested that image errors may have occurred because research by these three groups was carried out around the same time using the same equipment and therefore images may have been misused. The Chengdu University of Traditional Chinese Medicine is neither listed among the affiliations of the authors of [1] nor mentioned in this article, and the explanation that the images may have been misused because different groups used the same equipment around the same time raises serious concerns about the overall data handling by the research groups. The underlying data provided by first author JD were insufficient to resolve the above concerns.

The above concerns call into question the reliability and provenance of the results. Therefore, the PLOS ONE Editors retract this article.

JD did not agree with the retraction. MY, RJ, NA, XW, and BL either did not respond directly or could not be reached.

Note: For panels in [1] that appear to overlap with the 2015 article [2], refer to the CC-BY 4.0 DEED license that applies to the original publication.

References

  1. 1. Deng J, Yang M, Jiang R, An N, Wang X, Liu B (2017) Long Non-Coding RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the Cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast Cancer Cells. PLoS ONE 12(1): e0170860. https://doi.org/10.1371/journal.pone.0170860 pmid:28122024
  2. 2. Chen C, Zhao Z, Li Y, and Mu D (2015) microRNA‑99a is downregulated and promotes proliferation, migration and invasion in non‑small cell lung cancer A549 and H1299 cells. Oncology Letters 9(3): 1128–1134. https://doi.org/10.3892/ol.2015.2873 pmid:25663868
  3. 3. Zou Y, Yang J, Wu J, Luo C, and Huang Y (2017). miR‑133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion. Oncology Letters 15(1): 1097–1102. https://doi.org/10.3892/ol.2017.7432 pmid:29399170
  4. 4. Hu Q, Li Y, Chen H, Liao H, He Y, and Zheng Q (2022). CCDC88A Post-Transcriptionally Regulates VEGF via miR-101 and Subsequently Regulates Hepatocellular Carcinoma. Frontiers Immunology 13: eCollection 2022. https://doi.org/10.3389/fimmu.2022.859331 pmid:35493459
  5. 5. Zhang K, Hu J, Zhao Z (2023) Fumagillin regulates stemness and malignancies in cancer stem-like cells derived from liver cancer via targeting to MetAP-2. PLoS ONE 18(7): e0289024. https://doi.org/10.1371/journal.pone.0289024 pmid:37506053
  6. 6. The PLOS ONE Editors (2024) Retraction: (2023) Fumagillin regulates stemness and malignancies in cancer stem-like cells derived from liver cancer via targeting to MetAP-2. PLoS ONE 19(3): e0300802. https://doi.org/10.1371/journal.pone.0300802

Citation: The PLOS ONE Editors (2024) Retraction: Long Non-Coding RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the Cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast Cancer Cells. PLoS ONE 19(3): e0300804. https://doi.org/10.1371/journal.pone.0300804

Published: March 26, 2024

Copyright: © 2024 The PLOS ONE Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.