Following the publication of this article [1], multiple concerns were raised regarding the results and text. Specifically,
- Values in Tables 2 and 3 described as standard deviation (SD) consistently represent 5% of the mean.
- There is text overlap between the Discussion section of [1] and previously published articles with no shared authors [2, 3], without attribution.
- There is text overlap between the Methods and Results sections of [1] and other works by the same author group that were published first [4, retracted in 5, 6, 7]. Text reuse was not cited or acknowledged in [1] and similar submitted manuscripts were not declared during the peer review process as is required by PLOS policy.
- Error bars in Figures 4, 5, 7 and 8 do not appear uniform, and it is not clear if these error bars represent SD as described in the legends or if they were calculated as 5% of the mean as in the tables.
- The numbers of animals reported in the Methods section and Results do not align.
The corresponding author stated that an error occurred in the calculation of SD values. They provided updated tables presenting mean ± standard deviation, as well as raw numerical data underlying the results presented in these tables.
The author also stated that one-way ANOVA was used to compare groups in the tables, however they did not clarify if a post-hoc test was used to compare individual groups, and overall the statistical analysis methods are not adequately reported.
In light of the above issues, the article does not meet the journal’s reporting and policy requirements and PLOS remains concerned about the validity and reliability of the reported quantitative results. Therefore, the PLOS ONE Editors retract this article. We regret that the issues were not identified before the article was published.
All authors either did not respond directly to the editorial decision or could not be reached.
References
- 1. Ze Y, Sheng L, Zhao X, Hong J, Ze X, Yu X, et al. (2014) TiO2 Nanoparticles Induced Hippocampal Neuroinflammation in Mice. PLoS ONE 9(3): e92230. https://doi.org/10.1371/journal.pone.0092230 pmid:24658543
- 2. Hui H, Dotta F, Di Mario U, Perfetti R. (2004) Role of caspases in the regulation of apoptotic pancreatic islet beta cells death. J Cell Physiol 200(2):177–200. pmid:15174089
- 3. Yang J, Liu Q, Zhang L, Wu S, Qi M, Lu S, et al. (2009) Lanthanum chloride impairs memory, decreases pCaMK IV, pMAPK and pCREB expression of hippocampus in rats. Toxicol Lett 190:208–214 pmid:19643171
- 4. Cheng Z, Zhao H, Ze Y, Su J, Li B, Sheng L, et al. (2013) Gene-Expression Changes in Cerium Chloride-Induced Injury of Mouse Hippocampus. PLoS ONE 8(4): e60092. https://doi.org/10.1371/journal.pone.0060092 pmid:23573234
- 5. The PLOS ONE Editors (2024) Retraction: Gene-Expression Changes in Cerium Chloride-Induced Injury of Mouse Hippocampus. PLoS ONE 19(1): e0297257. https://doi.org/10.1371/journal.pone.0297257
- 6. Sang X, Li B, Ze Y, Hong J, Ze X, Gui S, et al. (2013) Toxicological mechanisms of nanosized titanium dioxide-induced spleen injury in mice after repeated peroral application. J. Agr. Food Chem. 61, 5590–5599. pmid:23621103
- 7. Sang X, Fei M, Sheng L, Zhao X, Yu X, Hong J, et al. (2014) Immunomodulatory Effects in the Spleen-Injured Mice Following Exposure to Titanium Dioxide Nanoparticles. J. Biomed. Mater. Res. A 102, 3562–3572. pmid:24243549
Citation: The PLOS ONE Editors (2024) Retraction: TiO2 Nanoparticles Induced Hippocampal Neuroinflammation in Mice. PLoS ONE 19(1): e0297256. https://doi.org/10.1371/journal.pone.0297256
Published: January 11, 2024
Copyright: © 2024 The PLOS ONE Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.