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Correction: The Effects of 17-Methoxyl-7-Hydroxy-Benzene-Furanchalcone on the Pressure Overload-Induced Progression of Cardiac Hypertrophy to Cardiac Failure

  • Jianchun Huang,
  • XiaoJun Tang,
  • Xingmei Liang,
  • Qingwei Wen,
  • Shijun Zhang,
  • Feifei Xuan,
  • Jie Jian,
  • Xing Lin,
  • Renbin Huang

During the preparation of Fig 1C in this article [1], the underlying data for panel 3CI were inadvertently used to represent the data in panel 3CIV. In the updated Fig 1 below, the correct panel has been included for Fig 3CIV. Underlying data provided for the corrected Fig 1 are in S1 File. All raw data underlying the remainder of the results reported in the article are available from the first author.

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Fig 1. Effects of MHBFC on myocyte cross-sectional area, myocardial fibrosis, perivascular fibrosis, and hydroxyproline content in cardiac tissue of pressure-overload rats.

(A) Representative figure of myocyte cross-section (HE stain, x400); (B) statistic results of myocyte cross-section area; (C) representative figure of myocardial fibrosis (Masson’s stain, x100); (D) statistic results of myocardial fibrosis; (E) representative figure of perivascular fibrosis (Masson’s stain, x100); (F) statistic results of perivascular fibrosis; (G) hydroxyproline content in cardiac tissue. I: Sham group; II: Model group; III: MHBFC 6 mg kg-1 group; IV: MHBFC 12 mg kg-1 group; V: Lisinopril 15 mg kg-1 group. The myocyte cross-sectional area, levels of myocardial and perivascular fibrosis, and the hydroxyproline content all increased significantly when compared with the sham-operated rats. MHBFC at dose of 12 mg/kg for 6 weeks could reverse all these pathological changes in LVH parameters, and MHBFC at dose of 6 mg/kg for 6 weeks could reduce the myocyte cross-sectional area and level of myocardial fibrosis. The data are expressed as the mean±SD, n = 6. #P<0.05, ##P<0.01 vs. Sham group; *P<0.05, **P<0.01 vs. Model group.

https://doi.org/10.1371/journal.pone.0276104.g001

Supporting information

Reference

  1. 1. Huang J, Tang X, Liang X, Wen Q, Zhang S, Xuan F, et al. (2014) The Effects of 17-Methoxyl-7-Hydroxy-Benzene-Furanchalcone on the Pressure Overload-Induced Progression of Cardiac Hypertrophy to Cardiac Failure. PLoS ONE 9(3): e91834. https://doi.org/10.1371/journal.pone.0091834. pmid:24622486