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Retraction

Retraction: MicroRNA-503 Acts as a Tumor Suppressor in Osteosarcoma by Targeting L1CAM

  • The PLOS ONE Editors

Following the publication of this article [1], similarities were noted between this article and articles submitted by other research groups, including [2–10], of which one article [10] was previously retracted [11].

Similarities included the following figures, which appear to fully or partially overlap, despite being published in different articles and representing different conditions:

  • untreat panel in Fig 3A of [1], and pCDNA-MDM2 + scramble panel in Fig 4C of [2].
  • untreat and control panels in Fig 3B of [1], and pCDNA-MDM2 + miR-410 panel in Fig 4C of [2].
  • inhibitors panel in Fig 3B of [1], and miR-575 mimic panels in Fig 2C and 2D of [8].
  • L1CAM panel in Fig 4D of [1], WASF3 panel in Fig 3D of [4], PAQR3 panel in Fig 4D of [6], and BRD7 panel in Fig 4C of [7].

The corresponding author did not comment on the above concerns. They provided data files which did not appear to contain the full raw data underlying the published figure, and they stated that they are unable to provide the ethics approval documentation. Therefore, the concerns regarding the similarities between this article [1] and others [2–10] remain unresolved.

The unresolved concerns call into question the validity and provenance of the reported results, and the adherence of this article to the PLOS Authorship policy. Therefore, the PLOS ONE Editors retract this article [1].

All authors did not comment on the retraction decision, did not respond directly or could not be reached.

References

  1. 1. Chong Y, Zhang J, Guo X, Li G, Zhang S, Li C, et al. (2014) MicroRNA-503 Acts as a Tumor Suppressor in Osteosarcoma by Targeting L1CAM. PLoS ONE 9(12): e114585. https://doi.org/10.1371/journal.pone.0114585 pmid:25536034
  2. 2. Shen J, Niu W, Zhou M, Zhang H, Ma J, Wang L, et al. (2014) MicroRNA-410 Suppresses Migration and Invasion by Targeting MDM2 in Gastric Cancer. PLoS ONE 9(8): e104510. https://doi.org/10.1371/journal.pone.0104510 pmid:25136862
  3. 3. Xu N, Li Z, Yu Z, Yan F, Liu Y, Lu X, et al. (2014) MicroRNA-33b Suppresses Migration and Invasion by Targeting c-Myc in Osteosarcoma Cells. PLoS ONE 9(12): e115300. https://doi.org/10.1371/journal.pone.0115300 pmid:25546234
  4. 4. Shen L, Wang P, Yang J, Li X (2014) MicroRNA-217 Regulates WASF3 Expression and Suppresses Tumor Growth and Metastasis in Osteosarcoma. PLoS ONE 9(10): e109138. https://doi.org/10.1371/journal.pone.0109138 pmid:25289936
  5. 5. Niu G, Li B, Sun L, An C (2015) MicroRNA-153 Inhibits Osteosarcoma Cells Proliferation and Invasion by Targeting TGF-β2. PLoS ONE 10(3): e0119225. https://doi.org/10.1371/journal.pone.0119225 pmid:25793604
  6. 6. Xiu Y, Liu Z, Xia S, Jin C, Yin H, Zhao W, et al. (2014) MicroRNA-137 Upregulation Increases Bladder Cancer Cell Proliferation and Invasion by Targeting PAQR3. PLoS ONE 9(10): e109734. https://doi.org/10.1371/journal.pone.0109734 pmid:25330156
  7. 7. Xue Z, Zhao J, Niu L, An G, Guo Y, Ni L (2015) Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7. PLoS ONE 10(5): e0127682. https://doi.org/10.1371/journal.pone.0127682 pmid:26010572
  8. 8. Wang H, Yan C, Shi X, Zheng J, Deng L, Yang L, et al. MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells. FEBS Letters 589 (2015) 805–811. https://doi.org/10.1016/j.febslet.2015.02.013 pmid:25728273
  9. 9. Qian K, Mao B, Zhang W, Chen H. (2016). MicroRNA-561 inhibits gastric cancercell proliferation and invasion by downregulating c-Myc expression. American journal of translational research, 8(9), 3802–3811. pmid:27725860
  10. 10. Chen G, Lu L, Liu C, Shan L, Yuan D (2015) MicroRNA-377 Suppresses Cell Proliferation and Invasion by Inhibiting TIAM1 Expression in Hepatocellular Carcinoma. PLoS ONE 10(3): e0117714. https://doi.org/10.1371/journal.pone.0117714 pmid:25739101
  11. 11. The PLOS ONE Editors (2022) Retraction: MicroRNA-377 Suppresses Cell Proliferation and Invasion by Inhibiting TIAM1 Expression in Hepatocellular Carcinoma. PLoS ONE 17(3): e0266302. https://doi.org/10.1371/journal.pone.0266302 pmid:35325011

Citation: The PLOS ONE Editors (2022) Retraction: MicroRNA-503 Acts as a Tumor Suppressor in Osteosarcoma by Targeting L1CAM. PLoS ONE 17(6): e0269900. https://doi.org/10.1371/journal.pone.0269900

Published: June 8, 2022

Copyright: © 2022 The PLOS ONE Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.