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Open Access

Expression of Concern

Expression of Concern: Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation

  • The PLOS ONE Editors

After this article [1] was published, concerns were raised about similarities in some of the microscopy images in Figures 1A and 1D.

Specifically:

  • In Figure 1A in this article, the 0 RBV (μg/ml), 100 IFN-α (IU/ml) panel appears similar to the 40 RBV (μg/ml), 10 IFN-α (IU/ml) panel; the 10 RBV (μg/ml), 0 IFN-α (IU/ml) panel appears similar to the 20 RBV (μg/ml), 10 IFN-α (IU/ml) panel; and the 20 RBV (μg/ml), 0 IFN-α (IU/ml) panel appears similar to the 20 RBV (μg/ml), 1000 IFN-α (IU/ml) panel.
  • In Figure 1D in this article, the 0 RBV (μg/ml), 100 IFN-α (IU/ml) panel appears similar to the 10 RBV (μg/ml), 10 IFN-α (IU/ml) panel; and the 0 RBV (μg/ml), 250 IFN-α (IU/ml) appears similar to the 20 RBV (μg/ml), 250 IFN-α (IU/ml) panel.

Follow-up on these issues is ongoing; in the meantime, the PLOS ONE Editors issue this Expression of Concern.

In addition, please note that reference 16 in this article [1] has been retracted [2].

References

  1. 1. Panigrahi R, Hazari S, Chandra S, Chandra PK, Datta S, Kurt R, et al. (2013) Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation. PLoS ONE 8(8): e72791. pmid:24009705
  2. 2. Journal of General Virology 2021;86:3047–3053, pmid:16227227

Citation: The PLOS ONE Editors (2022) Expression of Concern: Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation. PLoS ONE 17(3): e0266498. https://doi.org/10.1371/journal.pone.0266498

Published: March 31, 2022

Copyright: © 2022 The PLOS ONE Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.