https://orcid.org/0000-0002-5237-0914
Figures
Abstract
Objective
To determine whether the participation of consultant gynaecologists in delivering early pregnancy care results in a lower rate of acute hospital admissions.
Design
Prospective cohort study and emergency hospital care audit; data were collected as part of the national prospective mixed-methods VESPA study on the “Variations in the organization of EPAUs in the UK and their effects on clinical, Service and PAtient-centred outcomes”.
Setting
44 Early Pregnancy Assessment Units (EPAUs) across the UK randomly selected in balanced numbers from eight pre-defined mutually exclusive strata.
Participants
6606 pregnant women (≥16 years old) with suspected first trimester pregnancy complications attending the participating EPAUs or Emergency Departments (ED) from December 2016 to July 2017.
Main outcome measures
Unplanned admissions to hospital following any visit for investigations or treatment for first trimester complications as a proportion of women attending EPAUs.
Results
205/6397 (3.2%; 95% CI 2.8–3.7) women were admitted following their EPAU attendance. The admission rate among 44 units ranged from 0% to 13.7% (median 2.8). Neither planned senior clinician presence (p = 0.874) nor unit volume (p = 0.247) were associated with lower admission rates from EPAU, whilst EPAU opening over the weekend resulted in lower admission rates (p = 0.027). 1445/5464 (26.4%; 95%CI 25.3 to 27.6) women were admitted from ED. There was little evidence of an association with planned senior clinician time (p = 0.280) or unit volume (p = 0.647). Keeping an EPAU open over the weekend for an additional hour was associated with 2.4% (95% CI 0.1% to 4.7%) lower odds of an emergency admission from ED.
Citation: Memtsa M, Goodhart V, Ambler G, Brocklehurst P, Keeney E, Silverio SA, et al. (2021) Differences in the organisation of early pregnancy units and the effect of senior clinician presence, volume of patients and weekend opening on emergency hospital admissions: Findings from the VESPA Study. PLoS ONE 16(11): e0260534. https://doi.org/10.1371/journal.pone.0260534
Editor: Gang Qin, Nantong University, CHINA
Received: April 5, 2021; Accepted: November 11, 2021; Published: November 30, 2021
Copyright: © 2021 Memtsa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the paper’s Supporting information files.
Funding: The VESPA study received funding from the NIHR Health Services & Delivery Research (HS&DR) programme grant number 14/04/41. The funder provided support in the form of salaries for authors MM, VG, GA, PB, EK, SS, ZA, JR, NK, JH, GB, JS, DJ; however, the funder and sponsors of the study did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the author contributions’ section. The role of the commercial company MASS Ltd, as an elite researcher in workforce modelling, was advisory with regards to data collection and analysis. MASS Ltd is a business consultancy specialising in analytics, data modelling, and workforce planning and configuration. MASS (NK) was commissioned by and became a member of the VESPA co-applicants’ group to provide the required workforce modelling expertise and knowledge. VESPA included the services provided by MASS in the submittal for funding to NIHR. In the submitted paper, there are no competing interests and MASS has no claim of ownership for any IP arising from or related to this paper. This commercial affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials.
Competing interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: MM, VG, GA, ZA, NK, JH, GB, RBA, JS, DJ has nothing to disclose. Peter Brocklehurst reports grants and personal fees from MRC, grants from MRC, NIHR HS&DR, NIHR HJTA, Wellcome Trust, personal fees from AG Biotest, outside the submitted work. Edna Keeney reports personal fees from Novartis Pharma, personal fees from Pfizer Inc., outside the submitted work. Sergio A. Silverio (King’s College London) is supported by the National Institute for Health Research Applied Research Collaboration South London [NIHR ARC South London] at King’s College Hospital NHS Foundation Trust. Jeff Round reports grants from NIHR, during the conduct of the study; and Dr Round is currently employed by the Insitute of Health Economics (IHE). The IHE receives funding from, and collaborates with, government, academic, not-for-profit and private sector organisations. The IHE does not currently receive funds for research related to the submitted work.
Introduction
Current constraints on health expenditure have compelled providers to explore ways of delivering a greater proportion of care in outpatient settings whilst maintaining good clinical outcomes and high levels of patient satisfaction. In the UK, the care of women experiencing complications in the first trimester of pregnancy is mainly provided in Early Pregnancy Assessment Units (EPAUs). They are organisational structures which operate in most acute hospitals in the UK and an increasing number of other countries worldwide [1–4]. They were established following a publication by Bigrigg and Read [5] in 1991 who reported on cost savings and improved quality of early pregnancy care following the opening of an EPAU in their local hospital. EPAUs are currently operating in most acute hospital units in the UK aiming to provide women with comprehensive early pregnancy care, which includes clinical and ultrasound assessment, laboratory investigations, further management, as well as counselling and support, all in an out-patient setting.
Research that could potentially guide recommendations and policies on staffing and configurations of EPAUs has been scarce [6–9]. The National Institute for Health and Care Excellence (NICE) guideline on Ectopic Pregnancy and Miscarriage (CG 154) [10] included a review of evidence comparing EPAUs with other models of providing early pregnancy care for women presenting with first trimester pregnancy complications. The NICE guideline developing group, which includes a patient and public involvement panel, concluded that the configuration of services between different units varied considerably but, due to paucity of data, they were unable to make recommendations on the optimal structure of EPAUs that would balance clinical and service outcomes against cost-effectiveness. As a result, the group prioritised the need for future good quality research into the relative effectiveness of different EPAU configurations [10]. Senior clinician (consultant gynaecologist) involvement in the delivery of acute clinical care has been of interest recently [11], as there is emerging evidence of their positive impact on Emergency Departments (EDs) and Acute Medical Units, contributing to reduced mortality, fewer emergency hospital admissions and accelerated discharge from hospital [12–14].
In this national prospective cohort study, we aimed to determine whether higher participation of senior clinicians in the delivery of first trimester pregnancy care would result in better quality clinical care reflected in a lower risk of acute admissions to hospital for women presenting with first trimester complications.
Methods
Study setting
Data for this observational study were collected as part of the VESPA study, a UK-wide prospective mixed-methods study on the “Variations in the organization of EPAUs in the UK and their effects on clinical, Service and PAtient-centred outcomes”. We report the data from two of the VESPA study strands: 1) the prospective cohort study of women attending EPAUs due to first trimester complications; and 2) the emergency hospital care audit of women admitted as an emergency with first trimester pregnancy complications.
Prior to unit recruitment, a national survey was distributed to all 212 EPAUs operating in UK NHS hospitals between 2015 and 2016. A total of 205 EPAUs which completed the survey reported on unit location, opening hours, access to services, and staffing configurations. These responses were used to categorize the units according to three factors: planned senior clinician presence (yes or no); weekend opening (yes or no); and the annual volume of patients, as reported by the corresponding clinicians (low volume <3000 appointments per year vs. high volume ≥3000 appointments annually). These three factors were selected as being important factors associated with clinical outcomes from the literature [6]. Units were divided into eight mutually exclusive strata based on these characteristics, and 5 or 6 EPAUs were randomly selected from each stratum to a total of 44 for inclusion in the VESPA study. This technique was adopted to ensure that units of all configurations were equally represented in the final sample. The unit characteristics were confirmed again immediately prior to commencing patient recruitment.
Patient involvement
Patients and members of the public were involved at several stages of the study, including the design, management, and conduct of the study. We received input from patients who had experienced first trimester pregnancy complications in the design and timing of the study materials, and management oversight through membership of the study steering committee. A user-led organization (Miscarriage Association), through its national director, acted as a co-applicant and collaborator. We carefully assessed the burden and timings of the study participation and questionnaires on patients. Study participants will not be individually informed of the study results; however, dissemination to the public will be through media outreach (e.g., press release) upon publication of this study.
Study population
The VESPA study recruited from the EPAU population. All women aged ≥16 years of age who attended the participating EPAUs presenting with first trimester pregnancy complications for the first time during the index pregnancy were included in the cohort study. The upper gestational age limit was set at 13+6 weeks’ gestation in order to keep recruitment from all participating EPAUs consistent. Non-identifiable demographic and routine clinical data were collected for all women attending the participating EPAUs, and if women gave their written consent to participate to the VESPA study, their clinical data were linked. Clinical follow-up was not standardised but was based on local management protocols and women’s medical needs.
For the emergency hospital care audit strand, data from routine hospital databases for women attending hospital emergency services (EDs) at the same location as the EPAU were collected in collaboration with the Information Services (IS) departments in the participating hospitals. We collected data about the total number of Emergency Department attendances and emergency in-patient admissions of women who presented with first trimester pregnancy complications. Wherever possible, all data relating to hospital admissions provided by the IS departments were crosschecked by a member of the research team against ward admission books/databases in an attempt to check their accuracy. The aim was to capture hospital emergency activity with regards to early pregnancy care in EDs. These data were collected retrospectively at the end of the three-month period corresponding to the date when the last woman recruited to the cohort study was discharged from each hospital’s EPAU.
Emergency admission
The variable ‘Emergency admission’ indicates whether a patient had an unplanned admission to hospital following any visit for investigations or treatment of first trimester pregnancy complications. The primary outcome for the VESPA study was the number of emergency admissions as a proportion of women attending each participating EPAU. As a secondary outcome, we aimed to establish the number of emergency hospital admissions for women attending EDs in the same location as the EPAU for first trimester pregnancy complications.
Senior clinician presence
Planned senior clinician presence was defined as the percentage of planned hours which they were expected to spend in the unit according to their weekly timetable, divided by the planned unit opening hours. This variable was also dichotomised for some analyses to indicate whether they were expected to spend any time in EPAU (yes/no). During patient recruitment, we collected data on the grade of all members of staff present in the EPAU during its opening hours, their involvement in delivering early pregnancy care, as well as the actual hours which each member of staff spent in the unit. We could therefore calculate the actual amount of time senior clinicians spent in EPAU delivering clinical care. Actual senior clinician presence was defined as the percentage of hours they spent in EPAUs delivering care divided by the unit opening hours.
Other covariates
Unit volume.
Unit volume was defined as the number of patient visits per year and was estimated using the time taken to obtain data on the required number of patients and the average number of visits per patient. This variable was also dichotomised for some analyses to indicate whether the annual number of patient visits for a unit was above or below the median.
Weekend opening.
The total number of opening hours per weekend was used to illustrate weekend opening. For some analyses, this variable was also dichotomised to indicate whether a unit was open at weekends (yes/no), whilst a three-level weekend opening variable was defined: None/Saturday only/Saturday and Sunday.
Gestational age policy.
At the time of patient recruitment, we collected information about the unit referral policy with regards to the minimum gestational age at which women could be seen at the EPAU. The variable Gestational Age Policy (GAP) captures whether units either accepted referrals for women of any gestational age or only reviewed women of six weeks’ gestation or more.
Final diagnosis.
Final diagnosis (FD) was divided into five groups: 1) Normal intrauterine pregnancy including early and live pregnancies; 2) Abnormal intrauterine pregnancy including early embryonic demise, incomplete, and complete miscarriage; 3) Ectopic pregnancy at any site; 4) Pregnancy of unknown location; and 5) Other: molar pregnancy, multiple pregnancy, and not pregnant.
Statistical considerations
Sample size.
In preparation for the study, we carried out a prospective audit of clinical activity in eight EPAUs in London, UK, which included 3,600 women. This showed substantial variations in the proportion of in-patient emergency admissions with 8.5% in units without, and 3.5% in those with, senior clinician presence. Based on this study, the sample size of 44 units, each contributing 150 patients, was calculated to give us 90% power to detect a 5% absolute difference in the risk of an emergency admission. A moderate level of clustering within units (Intraclass Correlation Coefficient, ICC = 0.04) was assumed.
Statistical analysis.
The association between the three factors: senior clinician presence, unit volume, and weekend opening hours, and the proportion of emergency admissions was investigated by using regression models, where hierarchical models were used for analysing patient-level data, and standard models were used for analysing unit-level data. Most models were adjusted using one of two sets of potential confounder variables: i) maternal age and final diagnosis (MA+FD) or; ii) maternal age, final diagnosis, IMD and gestational age policy (MA+FD+IMD+GAP). Two sets were used because IMD and gestational age policy had a reasonable amount of missing data.
We performed sensitivity analyses by refitting the regression models using the binary variables for planned senior clinician presence, unit volume and weekend opening hours.
The relationship between emergency admissions from Emergency Departments and senior clinician presence, unit volume, and weekend opening hours was investigated by fitting multivariable logistic regression models. Models were either unadjusted or adjusted for gestational age unit policy.
Results
The study ran from December 2016 to July 2017. We obtained clinical data from 6,606 women. All units were asked to recruit a minimum number of 150 women each. Forty units met this target, whilst four units recruited between 143 and 149 women. 33 days (IQR 24–47) was the median time for units to complete recruitment.
Upon completion of data collection, we revisited the activity in all 44 units. The majority of units (37/44) had a unit volume of less than 4000 visits per year, and 22 units had a yearly visit volume lower than 2500 visits per year. In view of this, we revised our cut-off and used ≥2500 instead of ≥3000 visits to describe the units as high or low volume in the final data analysis. Twenty-three units were open during weekends. Senior clinicians were present only in 19 of the 44 EPAUs. This was due to the changes in provision of medical cover which occurred between the site initiation visit and the start of recruitment. A summary of all units showing their characteristics in respect to the key factors of interest and outlining participants’ median age, parity, deprivation score, ethnicity and gestational age at presentation is provided in Table 1. This is based on 6397 women that had complete information on the outcome and key characteristics.
A total of 205/6397 (3.2%; 95% CI 2.8–3.7) women were admitted following their EPAU attendance. The median admission rate among 44 units was 2.8% (range 0% to 13.7%) (Fig 1). The admission rates by patient characteristics is shown in Table 2. These are further broken down by diagnosis in Tables 3 and 4.
Initially, we investigated the association between senior clinician presence, unit volume, and weekend opening hours on emergency admissions from EPAU. There was no apparent relationship between planned senior clinician presence and emergency admissions (Fig 2).
Fitting hierarchical logistic regression models for ‘Emergency admission from EPAU’, there was little evidence of an association between the admission rate and planned senior clinician presence or unit volume controlled for final diagnosis and maternal age, as shown in Table 5. However, there was evidence of an association between the emergency admission rate and weekend opening hours. That is, a one-hour increase in weekend opening hours was associated with a 3.0% (95% CI: 0.3% to 5.8%) increase in the odds of an emergency admission from EPAU. These associations did not markedly change after further confounder adjustment. They were also similar if we consider patients with normally-developing pregnancies (FD group 1) and abnormally-developing pregnancies (FD groups 2–5) (Table 6).
We found that, in general, the actual amount of time spent by the senior clinicians in the units was less than planned, and in only five units, they were present for more than 5% of the time (Fig 3).
We next investigated the relationship between emergency admissions from the Emergency Department and planned senior clinician presence in EPAU, unit volume and weekend opening hours of the EPAU. This analysis was based on the 29 units (5,464 patients) that were able to provide us with reliable data regarding the attendances to Emergency Department and emergency admissions out of hours. In total, 1,445/5,464 (26.4%; 95%CI 25.3 to 27.6) patients had an emergency admission from the Emergency Department. The percentage of emergency admissions from the Emergency Department ranged from 7% to 58% with the majority of the units having an emergency admission rate of between 10% and 30%. The relationship between emergency admissions from the Emergency Department and senior clinicians’ presence in EPAU is shown in Fig 4.
Fitting multivariable logistic models, we found an association between the emergency admissions from the Emergency Department and weekend opening (p = 0.037). A 1-hour increase in the weekend opening hours of the EPAU was associated with 2.4% (95% CI: 0.1% to 4.7%) lower odds of an emergency admission from the Emergency Department. However, there was little evidence of an association with unit volume (p = 0.647) or planned senior clinician time (p = 0.280).
Discussion
We found no significant association between senior clinician presence in EPAUs and the proportion of women admitted for suspected first trimester pregnancy complications. We obtained similar results whether we analysed for senior clinician presence as a binary outcome or as a continuum. Having collected contemporaneous data documenting the actual time that senior clinicians spent in the EPAU delivering early pregnancy care, we found no significant association whether we analysed for planned or actual presence of the senior clinicians in EPAU. Statistical models were adjusted for final diagnosis, maternal age at initial visit, deprivation score, and unit referral policy regarding gestational age, as these variables have a known effect on the rate of emergency admissions [15–17].
Our findings are in contrast with the results of previous studies in other clinical settings, which showed that involvement of more experienced clinicians in delivering emergency care results in a significant reduction in emergency hospital admissions and the length of stay in hospital [12, 18].
However, our study is the first large prospective study designed with a specific aim to study emergency admission rates in women presenting with acute first trimester pregnancy complications. We chose to study the rate of emergency admissions which is a recognised quality outcome indicator for acute hospital units [19, 20]. In addition, we recorded the amount of time senior clinicians (consultant gynaecologists) spent working in EPAUs which is of critical importance when assessing the impact of their presence on various clinical outcomes.
In addition to senior clinicians’ presence, we also explored the effect that weekend opening of an EPAU has on emergency admissions. Having collected detailed data on the opening hours of all participating EPAUs over the weekend, we were able to identify that one hour’s increase in the weekend opening hours of an EPAU resulted, as expected, in an increased probability of a woman with first trimester complications being admitted to hospital from the EPAU, but decreased the chance of an admission to hospital from the Emergency Department. Bearing in mind that women attending the ED are eight times more likely to be admitted than those seen in the EPAU, keeping EPAUs open over the weekend reduces the overall number of emergency admissions to hospital.
Our study has several limitations. The senior clinicians were actually spending less time in the EPAUs than expected. In view of that, we were unable to identify the threshold above which senior clinicians would need to be present in the units actively delivering early pregnancy care in order to improve clinical outcomes. In addition, obtaining good quality data on emergency admissions from the Emergency Department based on routine hospital databases proved to be challenging, and we were only able to confidently utilise the data obtained from a fraction of the participating units.
There are several possible explanations for our findings. When we compared actual with planned senior clinicians’ presence, we found that in only 3/19 units (16%) did senior clinicians spend more than 15% of their time actively delivering clinical care, and in 13/19 units (68%) their actual documented presence was less than 5%. This relatively low level of senior clinicians’ involvement could explain the lack of an observed association between their presence and emergency admissions in this study. The other possibility is that senior clinicians, who are fully trained in general obstetrics and gynaecology, lack the additional clinical and ultrasound skills necessary for the effective running of an EPAU. Despite the fact that an advanced training module in acute gynaecology and early pregnancy has been running for a number of years from The Royal College of Obstetricians and Gynaecologists, to our knowledge, a rigorous assessment of its quality and effectiveness has not been undertaken [21]. It is also unclear whether completion of the module is a requirement locally for appointment to EPAU leadership roles.
There is also a need to further explore the skill mix of a multidisciplinary team of nurses, midwives and sonographers, which could facilitate effective running of EPAUs in the absence of senior clinicians.
The results of our study indicate that the presence of senior clinicians in early pregnancy units may not lead to more effective care when this is measured by the proportion of women who are admitted as an emergency. This is an important finding for health providers as the cost of employing senior clinicians is much higher compared to nurses and other healthcare professionals. Equally, weekend opening of an EPAU, even for a limited number of hours, is associated with lower probability of emergency hospital admissions.
Future research is needed to assess whether increased participation of senior clinicians and actual time commitment in provision of early pregnancy care, a change in their training could have more significant impact on the rate of emergency admissions and other indicators of the quality of clinical care in early pregnancy.
Acknowledgments
This national study has been realised thanks to the participation and hard work of 44 Early Pregnancy Assessment Units and their supporting research staff, a large number of patients who took the time to advise us before and during the study, as well as complete questionnaires and take part in interviews, and a number of organisations and individuals, to which we are extremely grateful. We apologise for any inaccuracies in the following list of contributors, whose primary role has been described.
We would like to thank Ms Heidi Chandler; whose hard work and dedication was instrumental in securing the funding for this study.
We would like to express our gratitude to the 44 participating Early Pregnancy Assessment Units and their supporting research staff:
Aberdeen Maternity Hospital, Aberdeen
Addenbrookes’ Hospital, Cambridge
Barnsley Hospital, Barnsley
Bishop Auckland Hospital, Bishop Auckland
Bradford Royal Infirmary, Bradford
City Hospital, Sunderland
Ealing Hospital, Ealing
Epsom Hospital, Epsom
Forth Valley Royal Hospital, Larbert
Frimley Park Hospital, Camberley
Glangwili General Hospital, Carmarthen
Gloucestershire Royal Hospital, Gloucester
Good Hope Hospital, Sutton Coldfield
Heartlands Hospital, Birmingham
Heatherwood Hospital, Ascot
Hereford County Hospital, Hereford
Homerton University Hospital, London
Ipswich Hospital, Ipswich
Kettering General Hospital, Kettering
Lincoln County Hospital, Lincoln
Luton and Dunstable University Hospital, Luton
Maidstone Hospital, Maidstone
Newham University Hospital, Newham
Peterborough City Hospital, Peterborough
Princess Anne Hospital, Southampton
Queen Elizabeth Hospital, Gateshead
Queen Elizabeth The Queen Mother Hospital, Margate
Rotherham General Hospital, Rotherham
Royal Derby Hospital, Derby
Royal Devon and Exeter Hospital, Exeter
Royal Hallamshire Hospital, Sheffield
Royal Oldham Hospital, Oldham
Royal Surrey County Hospital, Guildford
Royal Sussex County Hospital, Brighton
Salisbury District Hospital, Salisbury,
St George’s University Hospital, London
St Mary’s Hospital, London
St Thomas’s Hospital, London
Tameside Hospital, Ashton-under-Lyne
The James Cook University Hospital, Middlesborough
The Queen’s Medical Centre, Nottingham
Warwick Hospital, Warwick
Wexham Park Hospital, Slough
York Hospital, York
Organisations
Association of Early Pregnancy Units (AEPU)
The Ectopic Pregnancy Trust
The Miscarriage Association
Study Steering Committee
Pat Doyle (Chairperson), Professor in Epidemiology, London School of Hygiene and Tropical Medicine
Cecilia Bottomley, Lead clinician for Early Pregnancy, Chelsea and Westminster Hospital
Elizabeth Bradley, General Practitioner, Hampstead Group Practice
Hannah-Rose Douglas, Research lead for Analytical Services, NHS England
Marjory Maclean, Consultant Obstetrician and Gynaecologist, NHS Ayrshire and Arran
Brad Manktelow, Associate Statistics Professor, University of Leicester
Alex Peace-Gadsby, Chair, The Ectopic Pregnacy Trust
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