Skip to main content
Advertisement
Browse Subject Areas
?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

  • Loading metrics

How to improve automated external defibrillator placement for out-of-hospital cardiac arrests: A case study

  • Dylan Aeby,

    Roles Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

    Affiliation Faculty of Medicine, University of Lausanne, Lausanne, Switzerland

  • Philippe Staeger,

    Roles Supervision, Writing – review & editing

    Affiliation Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland

  • Fabrice Dami

    Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

    fabrice.dami@chuv.ch

    Affiliation Emergency Department, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland

Abstract

Introduction

In out-of-hospital cardiac arrests (OHCAs), the use of an automatic external defibrillator (AED) by a bystander remains low, as AEDs may be misplaced with respect to the locations of OHCAs. As the distribution of historical OHCAs is potentially predictive of future OHCA locations, the purpose of this study is to assess AED positioning with regard to past locations of OHCAs, in order to improve the efficiency of public access defibrillation programs.

Methods

This is a retrospective observational study from 2014 to 2018. The locations of historical OHCAs and AEDs were loaded into a geodata processing tool. Median distances between AEDs were collected, as well as the number and rates of OHCAs covered (distance of <100 meters from the nearest AED). Areas with high densities of uncovered OHCAs (hotspots) were identified in order to propose the placement of additional AEDs. Areas over-covered by AEDs (overlays) were also identified in order to propose the relocation of overlapping AEDs.

Results

There were 2,971 OHCA, 79.3% of which occurred at home, and 633 AEDs included in the study. The global coverage rate was 7.5%. OHCAs occurring at home had a coverage rate of 4.5%. Forty hotspots were identified, requiring the same number of additional AEDs. The addition of these would increase the coverage from 7.5% to 17.6%. Regarding AED overlays, 17 AEDs were found to be relocatable without reducing the AED coverage of historical OHCAs.

Discussion

This study confirms that geodata tools can assess AED locations and increase the efficiency of their placement. Historical hotspots and AED overlays should be considered, with the aim of efficiently relocating or adding AEDs. At-home OHCAs should become a priority target for future public access defibrillation programs as they represent the majority of OHCAs but have the lowest AED coverage rates.

Introduction

Every year, 30.0 to 97.1 in 100,000 people suffer from an out-of-hospital cardiac arrest (OHCA), for which the survival rate varies from 3.1 to 20.4% according to different registries [1]. When defibrillation is provided within 3 to 5 minutes, it can significantly increase the survival rate [2], especially if coupled with effective chest compressions. However, in a large majority of cases, emergency medical services cannot reach the patient within this very short period of time [3]. Fortunately, defibrillation can be performed by bystanders if an automatic external defibrillator (AED) is available. Any OHCA taking place within a 100 m radius of an AED is considered to be "covered", as the device is reachable within 90 seconds by brisk walking, allowing defibrillation to be performed within 3–5 minutes [47], as recommended by the American Heart Association (AHA) [8]. Therefore, public authorities have launched public access defibrillation (PAD) programs, as recommended by the European Resuscitation Council Guidelines [2].

However, due to the cost of AEDs, it is only possible to place a limited number of them; therefore, their location must be methodical to ensure that they are as effective as possible. In addition to public AEDs, some AEDs are privately owned (by private communities or enterprises) and are placed based on different criteria (e.g., number of visitors, specific risks, marketing, to improve the company’s image), rather than following a well-conducted risk analysis [9].

Nevertheless, the use of an AED by a bystander remains low for a number of reasons. AEDs may be misplaced regarding location of OHCAs [46, 1012], be inaccessible at the time of the OHCA [1316] or not registered through the dispatch centre, or bystanders may have difficulty finding them because their locations are poorly indicated [17]. Finally, most OHCAs occur at home, often with no one else around, or with only a sole elderly witness, and these locations are less covered by AEDS [18].

Various studies have highlighted that OHCAs are distributed in clusters, which remain stable over the years [1921]. Therefore, these locations may be suitable candidates for the placement of AEDs, as they are potentially predictive of future OHCAs.

The purpose of this study is to assess the positioning of AEDs with regard to historical locations of OHCAs, in order to improve the efficiency of PAD programs, and to describe the work method.

Materials and methods

This is a retrospective observational study from January 1st 2014 to December 31st 2018 in the State of Vaud (Switzerland), a territory of 3,212.2 square kilometres with a population of 793,129 inhabitants. Its capital, Lausanne, has 148,000 inhabitants [22].

When the dispatch centre suspects an OHCA, including OHCAs occurring at home, an ambulance and an emergency physician with his own vehicle are dispatched. Simultaneously, lay responders are alerted via a web-application. If more than one lay responder is available and an AED is in the vicinity, one is directed to the victim and another toward the AED. Lay responders are not alerted for suspected traumatic OHCA. Police vehicles within the State are all equipped with AEDs and are registered within the State’s lay responder web-application. The dispatch centre has the locations of all public AEDs and most private ones, as the State strongly recommended that they are registered. For this study, all OHCAs for which an ambulance was dispatched were considered. Traumatic OHCAs, as well as OHCAs occurring on highways and in health care facilities (such as clinics, treatment and rehabilitation centres, medico-social establishments, medical practices, long term care and psychiatric hospitals) were excluded. OHCAs with an incomplete address were also excluded. The locations of the AEDs were obtained through the State’s dispatch centre. The following data were collected:

  • AED location and type (public or private places), available 24/7 as of 31st January 2019
  • OHCA location (home or public places such as workplace, street, sports club) and cause (cardiac, respiratory, others non-cardiac causes) from January 1st 2014 to December 31st 2018

Data processing

Base map and data are issue from OpenStreetMap and OpenStreetMap Foundation. The geolocalization analysis was performed on the Quantum Geographic Information System (QGIS, 3.2.3 Bonn), a free and open-source cross-platform desktop application that supports viewing, editing and analysis of geospatial data from the Geospatial Foundation Project. Addresses were converted into geographical locations with a longitude and latitude combination. This method has been validated in previous epidemiological studies [2326].

Median distances and coverage rate

The straight-line distance from each OHCA to the nearest AED (in meters) was computed by the software and then entered in a spreadsheet (Microsoft Excel, Microsoft Corp., Redmond, Washington, USA). Each OHCA was categorized into urban, intermediate or rural, according to the Swiss Federal Statistical Office [27]. OHCAs were also categorized in terms of the type of location (home vs public place). The median distances, interquartile range (IQR) and coverage rates (percentage of OHCAs covered in proportion to all OHCAs) were calculated for each category and type of location. In this study, according to the AHA recommendation, an OHCA where the nearest AED was within a 100 m radius was considered as “covered” [8].

Hotspots and AED overlays

Areas with ≥5 historical OHCAs within a 100 m radius (public or private place) and without an AED were defined as “hotspots” by the study team. Areas with <5 historical OHCAs were arbitrarily not considered, as this may imply an unreasonable number of AEDs to add. Hotspots were identified with QGIS, by running a uniform density estimation algorithm, and then displayed on a map. These hotspots are recommended for AED placement as they are potentially predictive of future OHCAs. The impact on the coverage rates and median distances following the installation of AEDs in these hotspots was then determined.

Areas with a high density of AEDs (>1) within a 100 m radius were defined as AED “overlays”. They were identified using the same method. Public AEDs in such areas could be relocated elsewhere, without significant loss of coverage.

Ethical approval

The project was submitted to the State’s Ethics committee. Due to the lack of clinical data from the patients, a formal request was deemed unnecessary as it is not a concern regarding the law on Human research

Results

During the study period, 2,971 OHCAs were eligible for inclusion, and 2,225 were finally included (Fig 1). There were 633 public and private registered AEDs available 24/7 on January 31st 2019.

Median distances and coverage rate

The median distance from each OHCA to the nearest AED is 410.9 m (IQR: 216–1004 m). This equates to median distances of 319.7 m (IQR: 184–538 m) in urban municipalities, 1874.7 m (IQR: 535–2846 m) in rural municipalities and 759.9 m (IQR: 351–1619 m) in intermediate municipalities (Table 1). The global AED coverage rate of historical OHCAs is 7.5% (167/2225), specifically 10.3% (144/1399) in urban municipalities, 2.9% (10/340) in rural municipalities and 2.7% (13/486) in intermediate municipalities (Table 1). In terms of the type of location, 1765 (79.3%) of OHCAs occurred at home. The median distance from the OHCAs that occurred at home to the nearest AED is 429.4 m (IQR: 243–1086 m), and the coverage rate is 4.5% (79/1765). The median distance to the nearest AED in out-of-home OHCAs (i.e., public areas, workplaces) is 303.1 m (IQR: 137–783 m), and the coverage rate is 19.1% (88/460), as shown in Table 2. Table 3 shows the results for Lausanne, the State’s capital.

thumbnail
Table 1. OHCA characteristics categorized by the type of municipality.

https://doi.org/10.1371/journal.pone.0250591.t001

thumbnail
Table 2. OHCA characteristics categorized by location type.

https://doi.org/10.1371/journal.pone.0250591.t002

thumbnail
Table 3. OHCA characteristics in Lausanne, the State’s capital.

https://doi.org/10.1371/journal.pone.0250591.t003

Hotspots and AED overlays

There are 40 hotspots (≥ 5 OHCAs within a 100 m radius not covered by an AED): 38 in urban areas and 2 in intermediate locations. There are no hotspots in rural communities. If these hotspots were equipped with AEDs, 225 additional historical OHCAs (213 in urban areas and 12 in intermediate areas) would be covered. The coverage rate would then rise from 7.5% (167/2225) to 17.6% (392/2225). The impact of additional AEDs is shown in Tables 13. Fig 2 presents the area with the highest concentration of uncovered OHCAs and shows how adding three AEDs would improve the coverage. More hotspots and recommended AED placements can be found in the S1 File.

thumbnail
Fig 2. Map of the highest concentrations of uncovered OHCAs in the State.

The density of uncovered OHCAs in an area is defined by the number of uncovered OHCAs located in a radius of 100 m.

https://doi.org/10.1371/journal.pone.0250591.g002

Regarding AED overlays, 17 public AEDs could be relocated without reducing the AED coverage rate in the State. Fig 3 illustrates an example of severe overlap, where AEDs 1 and 2 could be removed. More suggestions to replace AEDs can be found in the S2 File.

thumbnail
Fig 3. Map of the area with the highest AED density of the State of Vaud.

The AED density of an area is defined by the number of AEDs within a 100 m radius.

https://doi.org/10.1371/journal.pone.0250591.g003

S3 File provides a comparison of AED coverage rates from previous works and the present study.

Discussion

This study proposes a method to evaluate the efficiency of the PAD coverage in an urban and rural territory. It confirms that it is possible to improve the spatial coverage rate of historical OHCAs by adding new AEDs and also points to a less common concept of relocating AEDs that are inefficiently placed (overlapping) to main hotspot areas. Adding an AED to each identified hotspot would increase the coverage rate and would require 40 AEDs for the whole State. Working on overlays and relocating overlapping AEDs, the example in our study shows that it would be possible to relocate 17 AEDs, thus sparing the number of new AEDs that would be required.

The study also confirms that the majority of OHCAs take place at home (79.3%) and that their coverage rate is poor (4.5%), four times lower than in public places (19.1%) [18].

The concept of improving the spatial or spatio-temporal AEDs coverage rate is not new [4, 6, 12, 28]; however, improving the efficiency of PADs by relocating AEDs is less known.

Tierney et al. developed a flexible location model for AEDs, which includes the relocation of existing AEDs to improve coverage [7]. The present work uses a less complex method but emphasizes the opportunity of saving costs while improving a public system. When thinking about adding new AEDs, every PAD program should consider the possibility of relocating existing AEDs to improve coverage.

Besides improving hotspots, OHCAs occurring at home deserve special attention, especially in high-density areas. They represent the majority of OHCAs, yet an AED is rarely available. Until now, PAD programs have mainly focused on public areas because the benefits on survival have been demonstrated [2]. In addition, some studies concluded that the conditions for public defibrillation in residential areas were less favourable for several reasons [2, 2932], including a higher rate of non-shockable rhythms [33]. However, the context has changed with the emergence of lay responders who can be alerted by dispatch centres [34]. These programs show higher CPR rates [3436], more frequent shockable rhythms [29, 37, 38] and faster defibrillations [37, 3942]. Consequently, some authors are now calling for a paradigm shift from public, to all-access defibrillation [43]. This could be achieved by the expansion of AED networks in residential areas, accompanied by the development of systems of local lay responders [31, 40, 41, 44, 45].

Limitations

There were certain limitations with this study. Firstly, distances were calculated as the crow flies; therefore, vertical distances (height in a building) were not taken into account. Secondly, existing and unregistered AEDs do not appear in this study, but they have a limited impact on population coverage because dispatchers are unable to guide an OHCA bystander or lay responder to these AEDs if they are not listed. Finally, the count of AEDs was stopped on 31st January 2019, and more AEDs may have been registered since, thus increasing the coverage rate.

Conclusion

Geodata tools can be used to increase the coverage of OHCAs with AEDs by detecting historical OHCA hotspots and identifying overlapping AEDs, which could be moved for better coverage efficiency. At-home OHCAs represent the majority of OHCAs, yet they are poorly covered. These should become a priority target for future PAD programs.

Supporting information

S1 File. Recommended locations for new AEDs.

https://doi.org/10.1371/journal.pone.0250591.s001

(DOCX)

S2 File. Suggested public AEDs to be removed.

https://doi.org/10.1371/journal.pone.0250591.s002

(DOCX)

S3 File. Comparison of AED coverage rates from previous works and the present study.

https://doi.org/10.1371/journal.pone.0250591.s003

(DOCX)

References

  1. 1. Kiguchi T, Okubo M, Nishiyama C, Maconochie I, Hock Ong ME, Kern KB, et al. Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR). Resuscitation. 2020;152: 39–49. pmid:32272235
  2. 2. Perkins GD, Handley AJ, Koster RW, Castrén M, Smyth MA, Olasveengen T, et al. European Resuscitation Council Guidelines for Resuscitation 2015: Section 2. Adult basic life support and automated external defibrillation. Resuscitation. 2015;95: 81–99. pmid:26477420
  3. 3. Swiss heart society. Cardiac arrest. [cited 2019 April 27] Available from https://www.swissheart.ch/fr/prevention/comportement-en-cas-durgence/arret-cardio-circulatoire.html.
  4. 4. Chan TCY, Li H, Lebovic G, Tang SK, Chan JYT, Cheng HCK, et al. Identifying locations for public access defibrillators using mathematical optimization. Circulation. 2013;127: 1801–9. pmid:23553657
  5. 5. Neves Briard J, de Montigny L, Ross D, de Champlain F, Segal E. Is distance to the nearest registered public automated defibrillator associated with the probability of bystander shock for victims of out-of-hospital cardiac arrest? Prehosp Disaster Med. 2018;33: 153–9. pmid:29433603
  6. 6. Fredman D, Haas J, Ban Y, Jonsson M, Svensson L, Djarv T, et al. Use of a geographic information system to identify differences in automated external defibrillator installation in urban areas with similar incidence of public out-of-hospital cardiac arrest: a retrospective registry-based study. BMJ Open. 2017;7(5): e014801. pmid:28576894
  7. 7. Tierney NJ, Reinhold HJ, Mira A, Weiser M, Burkart R, Benvenuti C, et al. Novel relocation methods for automatic external defibrillator improve out-of-hospital cardiac arrest coverage under limited resources. Resuscitation. 2018;125: 83–9. pmid:29414670
  8. 8. Aufderheide T, Hazinski MF, Nichol G, Steffens SS, Buroker A, McCune R, et al. Community lay rescuer automated external defibrillation programs: key state legislative components and implementation strategies: a summary of a decade of experience for healthcare providers, policymakers, legislators, employers, and community leaders from the American Heart Association Emergency Cardiovascular Care Committee, Council on Clinical Cardiology, and Office of State Advocacy. Circulation. 2006;113: 1260–70. pmid:16415375
  9. 9. Verbrugghe M, De Ridder M, Kalaai M, Mortelmans K, Calle P, Braeckman L. Presence and use of automated external defibrillators in occupational setting, Belgium. Int J Occup Med Environ Health. 2018;31(5): 603–11. pmid:30160257
  10. 10. Sondergaard KB, Hansen SM, Pallisgaard JL, Gerds TA, Wissenberg M, Karlsson L, et al. Out-of-hospital cardiac arrest: probability of bystander defibrillation relative to distance to nearest automated external defibrillator. Resuscitation. 2018;124: 138–44. pmid:29217395
  11. 11. Levy MJ, Seaman KG, Millin MG, Bissell RA, Jenkins JL. A poor association between out-of-hospital cardiac arrest location and public automated external defibrillator placement. Prehosp Disaster Med. 2013;28: 342–7. pmid:23702153
  12. 12. Folke F, Lippert FK, Nielsen SL, Gislason GH, Hansen ML, Schramm TK, et al. Location of cardiac arrest in a city center: strategic placement of automated external defibrillators in public locations. Circulation. 2009;120: 510–7. pmid:19635969
  13. 13. Agerskov M, Nielsen AM, Hansen CM, Hansen MB, Lippert FK, Wissenberg M, et al. Public access defibrillation: great benefit and potential but infrequently used. Resuscitation. 2015;96: 53–8. pmid:26234893
  14. 14. Hansen CM, Wissenberg M, Weeke P, Ruwald MH, Lamberts M, Lippert FK, et al. Automated external defibrillators inaccessible to more than half of nearby cardiac arrests in public locations during evening, nighttime, and weekends. Circulation. 2013;128: 2224–31. pmid:24036607
  15. 15. Sun CLF, Demirtas D, Brooks SC, Morrison LJ, Chan TCY. Overcoming spatial and temporal barriers to public access defibrillators via optimization. J Am Coll Cardiol. 2016;68: 836–45. pmid:27539176
  16. 16. Karlsson L, Malta CH, Wissenberg M, Møller Hansen S, Lippert FK, Rajan S, et al. Automated external defibrillator accessibility is crucial for bystander defibrillation and survival: a registry-based study. Resuscitation. 2019;136: 30–7. pmid:30682401
  17. 17. Brooks B, Chan S, Lander P, Adamson R, Hodgetts GA, Deakin CD. Public knowledge and confidence in the use of public access defibrillation. Heart. 2015;101: 967–71. pmid:25926599
  18. 18. Gräsner J-T, Lefering R, Koster RW, Masterson S, Böttiger BW, Herlitz J, et al. EuReCa ONE 27 Nations, ONE Europe, ONE Registry: a prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation. 2016;105: 188–95. pmid:27321577
  19. 19. Demirtas D, Brooks SC, Morrison LJ, Chan TC. Abstract 15003: Spatiotemporal stability of public cardiac arrests. Circulation. 2015;132: A15003–A15003.
  20. 20. Sasson C, Keirns C, Smith D. Small area variations in out-of-hospital cardiac arrest: does the neighborhood matter? Ann Intern Med. 2010;153: 19. pmid:20516307
  21. 21. Lerner EB, Fairbanks RJ, Shah MN. Identification of out-of-hospital cardiac arrest clusters using a geographic information system. Acad Emerg Med. 2005;12: 81–4. pmid:15635143
  22. 22. Swiss Statistics office. [cited 2019 June 7] Available from https://www.bfs.admin.ch/bfs/fr/home/statistiken/regionalstatistik/regionale-portraets-kennzahlen/kantone/waadt.html.
  23. 23. Faure E, Danjou AMN, Clavel-Chapelon F, Boutron-Ruault M-C, Dossus L, Fervers B. Accuracy of two geocoding methods for geographic information system-based exposure assessment in epidemiological studies. Environ Health. 2017;16: 15. pmid:28235407
  24. 24. Roongpiboonsopit D, Karimi HA. Comparative evaluation and analysis of online geocoding services. Int J Geogr Inf Sci. 2010;24: 1081–100.
  25. 25. Singh SK. Evaluating two freely available geocoding tools for geographical inconsistencies and geocoding errors. Open Geospatial Data Softw Stand. 2017;2.
  26. 26. Karimi HA, Sharker MH, Roongpiboonsopit D. Geocoding recommender: an algorithm to recommend optimal online geocoding services for applications. Trans GIS. 2011;15: 869–86.
  27. 27. Swiss office of statistics. [cited 2019 April 25] Available from https://www.atlas.bfs.admin.ch/maps/13/fr/12362_12361_3191_227/20389.html#
  28. 28. Sun CLF, Karlsson L, Torp-Pedersen C, Morrison LJ, Brooks SC, Folke F, et al. In silico trial of optimized versus actual public defibrillator locations. J Am Coll Cardiol. 2019;74: 1557–67. pmid:31537265
  29. 29. Hansen SM, Hansen CM, Folke F, Rajan S, Kragholm K, Ejlskov L, et al. Bystander defibrillation for out-of-hospital cardiac arrest in public vs residential locations. JAMA Cardiol. 2017;2: 507–14. pmid:28297003
  30. 30. Bardy GH, Lee KL, Mark DB, Poole JE, Toff WD, Tonkin AM, et al. Home use of automated external defibrillators for sudden cardiac arrest. N Engl J Med. 2008;358: 1793–804. pmid:18381485
  31. 31. Folke F, Gislason GH, Lippert FK, Nielsen SL, Weeke P, Hansen ML, et al. Differences between out-of-hospital cardiac arrest in residential and public locations and implications for public-access defibrillation. Circulation. 2010;122: 623–30. pmid:20660807
  32. 32. Tay PJM, Pek PP, Fan Q, Ng YY, Leong BS-H, Gan HN, et al. Effectiveness of a community based out-of-hospital cardiac arrest (OHCA) interventional bundle: results of a pilot study. Resuscitation. 2020;146: 220–8. pmid:31669756
  33. 33. Weisfeldt ML, Rea T, Bigham B, Brooks SC, Foerster C, Gray R, et al. Ventricular tachyarrhythmias after cardiac arrest in public versus at home. N Engl J Med. 2011: 364: 313–321. pmid:21268723
  34. 34. Ringh M, Rosenqvist M, Hollenberg J, Jonsson M, Fredman D, Nordberg P, et al. Mobile-phone dispatch of laypersons for CPR in out-of-hospital cardiac arrest. N Engl J Med. 2015;372: 2316–25. pmid:26061836
  35. 35. Hansen CM, Kragholm K, Pearson DA, Tyson C, Monk L, Myers B, et al. Association of bystander and first-responder intervention with survival after out-of-hospital cardiac arrest in North Carolina, 2010–2013. JAMA. 2015;314: 255–64. pmid:26197186
  36. 36. Caputo ML, Muschietti S, Burkart R, Benvenuti C, Conte G, Regoli F, et al. Lay persons alerted by mobile application system initiate earlier cardio-pulmonary resuscitation: a comparison with SMS-based system notification. Resuscitation. 2017;114: 73–8. pmid:28268186
  37. 37. Pijls RWM, Nelemans PJ, Rahel BM, Gorgels APM. A text message alert system for trained volunteers improves out-of-hospital cardiac arrest survival. Resuscitation. 2016;105: 182–7. pmid:27327230
  38. 38. Hansen MB, Lippert FK, Rasmussen LS, Nielsen AM. Systematic downloading and analysis of data from automated external defibrillators used in out-of-hospital cardiac arrest. Resuscitation. 2014;85: 1681–5. pmid:25281188
  39. 39. Karlsson L, Hansen CM, Vourakis C, Sun CL, Rajan S, Søndergaard KB, et al. Improving bystander defibrillation in out-of-hospital cardiac arrests at home. Eur Heart J Acute Cardiovasc Care. 2020. pmid:32166951
  40. 40. Zijlstra JA, Stieglis R, Riedijk F, Smeekes M, van der Worp WE, Koster RW. Local lay rescuers with AEDs, alerted by text messages, contribute to early defibrillation in a Dutch out-of-hospital cardiac arrest dispatch system. Resuscitation. 2014;85: 1444–9. pmid:25132473
  41. 41. Stieglis R, Zijlstra JA, Riedijk F, Smeekes M, Worp WE van der, Koster RW. AED and text message responders density in residential areas for rapid response in out-of-hospital cardiac arrest. Resuscitation. 2020;150: 187–188. pmid:32045663
  42. 42. Sarkisian L, Mickley H, Schakow H, Gerke O, Jørgensen G, Larsen ML, et al. Global positioning system alerted volunteer first responders arrive before emergency medical services in more than four out of five emergency calls. Resuscitation. 2020;152: 170–176. pmid:31923531
  43. 43. Rea T. Paradigm shift: changing public access to all-access defibrillation. Heart. 2018;104: 1311–2. pmid:29773656
  44. 44. Zijlstra JA, Koster RW, Blom MT, Lippert FK, Svensson L, Herlitz J, et al. Different defibrillation strategies in survivors after out-of-hospital cardiac arrest. Heart. 2018;104: 1929–36. pmid:29903805
  45. 45. Ringh M, Hollenberg J, Palsgaard-Moeller T, Svensson L, Rosenqvist M, Lippert FK, et al. The challenges and possibilities of public access defibrillation. J Intern Med. 2018;283: 238–56. pmid:29331055