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Correction: Serum matrix metalloproteinase 3 levels are associated with an effect of iguratimod as add-on therapy to biological DMARDs in patients with rheumatoid arthritis

  • Nao Tokai,
  • Shuzo Yoshida,
  • Takuya Kotani,
  • Ayaka Yoshikawa,
  • Yuko Kimura,
  • Youhei Fujiki,
  • Yoko Matsumura,
  • Tohru Takeuchi,
  • Shigeki Makino,
  • Shigeki Arawaka

There is an error in the second sentence of the Subjects and Methods section. The correct sentence is: This was defined as the state of 2.6 < DAS28ESR < 5.1 or PD score ≥ 2 in at least one of the 28 joints on US examination.

There is an error in the fourth sentence of the fifth paragraph of the Discussion section. The correct sentence is: Therefore, the effects of bDMARDs on the serum MMP-3 levels could not be evaluated accurately.

There is an error in the first sentence of the eighth paragraph of the Discussion section. The correct sentence is: According to a report by Hattori et al. analyzing 114 RA patients treated with adalimumab for 52 weeks or longer, the rate of improvement of the serum MMP-3 levels after 4 weeks was significantly higher in the DAS28-CRP remission group.

In Fig 3, the headings PSL using and PSL non-using are swapped. The left side should be PSL non-using and the right should be PSL using. Please see the corrected Fig 3 here.

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Fig 3.

Comparison of the serum MMP-3 levels at 12 weeks and the MMP-3 ratio between steroids using and non-using groups (A). Correlation between the serum MMP-3 levels at 12 weeks / the MMP-3 ratio and dosage of steroids (B). MMP-3 ratio, ratio of the serum matrix metalloproteinase 3 levels at baseline to those at 12 weeks; PSL, prednisolone.

https://doi.org/10.1371/journal.pone.0211750.g001

Reference

  1. 1. Tokai N, Yoshida S, Kotani T, Yoshikawa A, Kimura Y, Fujiki Y, et al. (2018) Serum matrix metalloproteinase 3 levels are associated with an effect of iguratimod as add-on therapy to biological DMARDs in patients with rheumatoid arthritis. PLoS ONE 13(8): e0202601. https://doi.org/10.1371/journal.pone.0202601 pmid:30138480