http://orcid.org/0000-0003-1233-959X
Figures
Abstract
Objectives
To investigate the long-term postoperative outcomes and predictive factors associated with poor surgical outcomes in mesial temporal lobe epilepsy (MTLE).
Materials and methods
We enrolled patients with MTLE who underwent resective surgery at single university-affiliated hospital. Surgical outcomes were determined using a modified Engel classification at the 2nd and 5th years after surgery and the last time of follow-up.
Results
The mean duration of follow-up after surgery was 7.6 ± 3.7 years (range, 5.0–21.0 years). 334 of 400 patients (83.5%) were seizure-free at the 5th postoperative year. Significant predictive factors of a poor outcome at the 5th year were a history of generalized tonic clonic (GTC) seizures (odds ratio, OR; 2.318), bi-temporal interictal epileptiform discharge (IED) (OR; 3.107), bilateral hippocampal sclerosis (HS) (OR; 5.471), unilateral HS and combined extra-hippocampal lesion (OR; 5.029), and bi-temporal hypometabolism (BTH) (OR; 4.438). Bi-temporal IED (hazard ratio, HR; 2.186), BTH (HR; 2.043), bilateral HS (HR; 2.541) and unilateral HS and combined extra-hippocampal lesion (HR; 2.75) were independently associated with seizure recurrence. We performed a subgroup analysis of 208 patients with unilateral HS, and their independent predictors of a poor outcome at the 5th year were BTH (OR; 5.838) and tailored hippocampal resection (OR; 11.053).
Citation: Shin JH, Joo EY, Seo D-W, Shon Y-M, Hong SB, Hong S-C (2018) Prognostic factors determining poor postsurgical outcomes of mesial temporal lobe epilepsy. PLoS ONE 13(10): e0206095. https://doi.org/10.1371/journal.pone.0206095
Editor: Giuseppe Biagini, University of Modena and Reggio Emilia, ITALY
Received: July 4, 2018; Accepted: October 6, 2018; Published: October 19, 2018
Copyright: © 2018 Shin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the paper and its Supporting Information files.
Funding: This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning, Republic of Korea (2017R1A2B4003120) and by Samsung Biomedical Research Institute grant (SMX1170571).
Competing interests: The authors have declared that no competing interests exist.
Introduction
The rate of complete remission of seizures after epilepsy surgery for mesial temporal lobe epilepsy (MTLE) is only 60% to 70%.[1] Almost one third of patients continue to have seizures after surgery. The long-term outcome is worse than the short-term outcome, with 48 to 58 percent continuing to experience seizures 5 years after surgery.[2,3] It is important to develop reliable predictors of surgical outcomes for MTLE and selecting proper surgical candidates remains a challenge.
Clinical predictors for long-term surgical outcomes differ from the variables that predict short-term outcomes.[2–7] A history of secondarily generalized tonic-clonic seizures (SGTCS) is associated with recurrent seizures in both the short- and long-term after surgery.[4,5] The presence of SGTCS was independently associated with poor 2-year outcomes but not with 5-year outcomes;[2] in that study, epilepsy duration was the only important negative predictor for 5-year outcomes. However, the significant relationship between epilepsy duration and surgical outcome existed only in TLE with a temporal tumor or gliosis,[6] not in non-lesional TLE patients.[7]
Emerging evidence suggests that neuroimaging studies might be able to predict surgical outcomes for TLE. Gray matter abnormalities on magnetic resonance imaging (MRI) other than hippocampal sclerosis (HS), including in the entorhinal cortex and posterior parahippocampal gyrus, were a poor prognostic factor for seizure recurrence.[8] However, no statistically significant difference in surgical outcomes was found between individuals with HS and those with HS plus gray-white matter abnormalities.[9] Brain 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) might help lateralize the seizure focus correctly and improve surgical outcomes in non-lesional TLE cases.[10] Hypometabolism that is not confined to unilateral temporal areas was associated with poor surgical outcomes in TLE patients.[11,12] Still, it is unclear whether hypometabolism extending beyond a unilateral temporal area is an independent factor predicting postoperative seizure outcomes. Patients with bilateral temporal hypometabolism (BTH) had features distinct from those with unilateral temporal hypometabolism (UTH), but their surgical outcomes did not differ.[13] Atypical hyperperfusion on single photon emission computed tomography (SPECT) was associated with poor outcomes and indicated diffuse or extra-temporal epileptogenicity.[14] Subtraction-ictal SPECT co-registered with MRI was known to enhance the diagnostic yield of epileptic foci.[15]
To the best of our knowledge, few longitudinal studies[16,17] have analyzed brain structural and functional abnormalities to find overall predictors of surgical outcomes in a large population with MTLE. We first aimed to assess poor postoperative prognostic factors in patients with MTLE using longitudinal analyses. It was hypothesized that the long-term and short-term outcomes might be affected by different sets of clinical factors. Second, we investigated whether preoperative neuroimaging results, along or in combination, predict seizure relapse after surgery.
Methods
Patient selection
We retrospectively reviewed the records of 868 patients with refractory epilepsy who underwent resective surgery between January 1995 and December 2011 at one university-affiliated hospital. A total of 400 patients with MTLE who underwent a standard anterior temporal lobectomy were enrolled. Epilepsy was intractable before surgery despite proper and sufficient antiepileptic drug (AED) treatment. Patients were diagnosed as having MTLE if (a) HS was seen on an MRI and mesial temporal ictal onset was identified during video-EEG monitoring, or (b) the MRI was normal or another definite pathologic lesion was found in the temporal or extratemporal regions on MRI, but video-EEG monitoring and other functional neuroimaging, including PET and SPECT, confirmed exclusive mesial temporal ictal onset. Patients with follow-up of less than 5 years were excluded. Clinical characteristics registered for each patient included age of seizure onset, age at surgery, duration of epilepsy, history of febrile seizures, SGTCS, central nervous system infections, and the existence of auras.
Ethics statement
All patients provided written informed consent for their participation in the study. Written informed consent was obtained from the next of kin, caretakers, or guardians on the behalf of the minors/children participants involved in this study. The study was approved by Institutional Review Board of Samsung Medical Center.
Presurgical evaluation
Intractable epilepsy patients received a comprehensive presurgical evaluation consisting of a complete neurologic examination, ictal and inter-ictal EEG results, and brain MRI during the first admission period. Ictal and inter-ictal SPECT studies[15,18,19] were performed to lateralize or localize the epileptic foci. Each patient underwent PET, a neuropsychological test, and the Wada test[13] during the second admission. All data from these admissions were reviewed and discussed in an epilepsy management conference at which surgical strategy was also discussed.
Analysis of clinical seizures during scalp video EEG monitoring
We reviewed each patient’s seizures carefully. The presence of an aura was determined by patient’s memory or the patient pressing a button before seizures.
Scalp video EEG monitoring
The 10/10 system for scalp electrodes was used. AEDs were usually reduced or stopped to facilitate the recording of seizures.
Interictal EEG classification[13].
Interictal epileptiform discharges (IEDs) were counted and analyzed over entire recording days and classified into temporal and extratemporal IED. Unilateral temporal IED was defined as strictly unilateral IED or as a 75% or more preponderance of IED in one temporal lobe if bilateral IED was present. Bilateral temporal IED was defined as a 74% or less preponderance in one temporal lobe. Temporal and extratemporal IEDs were indicated when IEDs from ipsi- or contralateral extratemporal regions were present with more than a 25% preponderance to the temporal IED.
Ictal EEG classification during scalp EEG recording[13].
A temporal ictal onset zone was defined when the location of the ictal discharges was uni- or bi-temporal, and the amplitude ratio of the temporal vs. parasagittal chain was higher than 2:1 in bipolar montages and higher than 2:1 for the 2 sides in referential montages. A hemispheric ictal onset zone was defined when ictal discharges arose from a lateralized hemisphere and the amplitude ratio of the temporal vs. parasagittal chain was lower than 2:1 in bipolar montages and lower than 2:1 for the two sides in referential montages.
Neuroimaging studies
Brain MRI.
MRI was performed using a GE Signa 1.5-Tesla scanner (GE Medical Systems, Inc., Milwaukee, WI, USA) or a 3.0-Tesla scanner (Philips, Best, the Netherlands). All patients underwent the spoiled gradient echo, T2-weighted, and fluid attenuated inversion recovery imaging protocols.[20] The MRI results were classified as 5 subtypes: (a) unilateral HS, (b) bilateral HS, (c) unilateral HS and combined extra-hippocampal lesion (mainly ipsilateral anterior temporal atrophy or diffuse hemiatrophy/focal cerebromalacia), (d) normal, and (e) tumorous lesion involving mesial temporal structures.
FDG-PET studies.
PET images were obtained (GE Advance PET scanner, GE Medical Systems, Inc.) after patients had fasted for four or more hours and then received an intravenous injection of 7–10 mCi (259–370 MBq) of FDG. EEG during the uptake period demonstrated no EEG seizure activity in any patient. Hypometabolism was determined semi-quantitatively by visual assessment using calibrated color scales with a high or absolute degree of inter-observer agreement. A graduated color scale in 2% increments was used for display and analyses. When the metabolism of the lobe showed a 20% or more reduction compared with the other areas of metabolism, it was regarded as abnormal hypometabolism.[13,21]
Surgery and outcomes
Intraoperative electrocorticography (ECoG) with subdural electrodes to verify epileptiform discharges was applied in all but 30 patients. If ECoG revealed active spikes in the brain regions adjacent to the standard resection margin, those active regions were supplementally resected.[20,22] We used relatively uniform surgical procedures. Three subtypes of resective operations were performed in our epilepsy center.[20] The first subtype was a standard anterior temporal lobectomy (ATL) with tailored amygdalohippocampectomy (AH) that included the anterior temporal neocortex, as well as a minimal part of the amygdaloid structures and partial hippocampal structures. The second subtype was ATL with a complete resection of the amygdala-hippocampus based on the intraoperative ECoG results. In the third subtype, an additional corticectomy guided by ECoG was added to the second subtype of surgery. The International League Against Epilepsy (ILAE) has recently proposed a simple classification of HS based on semiquantitative cell loss patterns that can be easily used by most laboratories. It identifies three HS types characterized characterized by cell loss affecting all of the sectors of the CA (type1), predominantly CA1 (type 2), or predominantly CA4 (type 3).[23] The resected mesial temporal specimens were analyzed just after surgery, and we classified those histopathologic results according to ILAE classification.
Postoperative seizure outcomes were determined by outpatient clinic interview or telephone interview using Engel’s classification.[24] The patients were instructed to visit the clinic one month after surgery and then every 3 months. If patients became seizure-free, they visited the clinic every six months. For this study, we evaluated the surgical outcomes 2 and 5 years after surgery and at the end of the study period. We also performed year-by-year analyses of surgical outcomes.
Statistical analyses
To compare seizure-free (Engel I) patients and patients with recurrent seizures (Engel II–IV), we applied Chi-square or Fisher’s exact test for categorical variables. A student’s t-test or the Mann-Whitney U test was performed for continuous variables. Logistic regression analyses were used to verify independent risk factors for seizure recurrence. Variables with p values ≤ 0.05 in the simple logistic regression were tested in the multiple logistic regression analyses. Adjustment for multiple comparisons was done by Fisher’s exact test using the permutation method. Statistical significance was accepted at p < 0.05. The time to first seizure recurrence was plotted using a Kaplan-Meier survival curve to estimate the proportion of individuals with several prognostic factors who remained seizure-free at various time points. A log rank test and a comparison of 95% confidence intervals were used to establish differences between good and bad prognostic factors for seizure recurrence after surgery.
Results
Patient characteristics
Demographic and clinical assessment data for subjects are summarized in Table 1. The mean age of seizure onset was 16.9 ± 10.3 years (range 0.2–52). The mean age at surgery was 30.3 ± 10.5 years (range 7–64). 233 (58.3%) patients experienced one or more tonic-clonic seizures before surgery. All patients underwent scalp video EEG and brain MRI. Functional imaging studies were performed in 245 patients (ictal SPECT with/without interictal SPECT) and 336 patients (FDG-PET).
Surgery, surgical outcome, and histopathology
All patients underwent ATL with partial or complete AH. 58 (14.5%) patients received partial AH, of which 38/58 (65.5%) were left sided. 172 (43%) patients showed an interictal spike on the ECoG recording during surgery, of whom 129/172 (75%) underwent a tailored corticectomy. There was no significant difference in surgical outcome between the positive ECoG group that received a corticectomy and the positive ECoG group that did not receive a corticectomy.
All cases were confirmed histopathologically after resective surgeries. We examined postoperative tissue from 382 of 400 MTLE surgeries. HS type could not be defined with certainty for 18 samples. The remaining tissue samples were classed as type1 HS for 288 patients (75.4%), type 2 for 6 patients (1.6%), type 3 for 2 patients (0.5%), and type no-HS for 44 patients (11.5%). 42 patients (11.0%) showed tumors involving the hippocampus without or with hippocampal sclerosis. Among 84 patients with unilateral HS and combined extra-hippocampal lesion, 53 patients showed ipsilesional anterior temporal abnormalities with various degrees of focal cortical dysplasia.
The mean follow-up duration after surgery was 7.6 ± 3.7 years (range, 5.0–21.0 years). The short-term (2-year) outcome data showed that 342 patients (85.5%) were in Engel class I: 337 (84.25%) in class Ia (ILAE class 1).[25] The long- term seizure free rate was good. 334 patients (83.5%) were Engel class I at the fifth year after surgery and 302 patients (79.1%) had an Engel class Ia (ILAE class 1) outcome. Of 13 patients with an Engel class IV two years after surgery, 99.7% (12/13) had persisting seizures at the last follow-up.
Factors predicting seizure outcomes two and five years after surgery
Subsequent multiple logistic regressions using variables significant in the univariate analyses at year two after surgery showed that tailoredhippocampal resection (OR, 5.295; 95% CI, 1.871–14.986), unilateral HS and combined extra-hippocampal lesion (OR, 3.643; 95% CI, 1.258–10.555), BTH (OR, 3.436; 95% CI, 1.118–9.941), bi-temporal IED (OR, 3.060; 95% CI, 1.389–6.738), and a history of GTC seizures (OR, 2.758; 95% CI, 1.267–6.000) were independently associated with poor outcomes. Significant prognostic factors for poor outcomes at year five after surgery were nearly the same as those at year two, except for bilateral HS on brain MRI (Table 2).
Survival analysis of seizure recurrence
Multivariate analyses using the Cox proportional hazards test demonstrated that a history of GTC seizures and tailored hippocampal resection had significantly high hazard ratios (HRs) (HR = 1.711; 95% CI = 1.026–2.855, HR = 2.834; 95% CI = 1.424–5.639, respectively). In the presurgical evaluation, bi-temporal IED (HR = 2.186; 95% CI = 1.288–3.709), BTH (HR = 2.04; 95% CI = 1.138–3.667), bilateral HS (HR = 2.541; 95% CI = 1.217–5.307) and unilateral HS and combined extra-hippocampal lesion (HR = 2.75; 95% CI = 1.589–4.758) were independently associated with seizure recurrence (Table 3).
We used a Kaplan Meier’s survival analysis to compare seizure-free survival according to different MRI findings and PET hypometabolism patterns. The survival curves show a significantly higher seizure-free ratio in patients with unilateral HS compared with bilateral HS or unilateral HS combined with extra-hippocampal lesion (log-rank test, p = 0.026 and p = 0.001, respectively) (Fig 1). In addition, patients with BTH (log-rank test, p < 0.001) and temporal plus extratemporal hypometabolism (log-rank test, p = 0.029) showed seizure recurrence more frequently than patients with UTH involving only mesial temporal and temporal pole structures (Fig 1).
(a) The Kaplan-Meier survival curves show statistically significant associations of bilateral HS and unilateral HS combined with extra-hippocampal lesion with seizure recurrence. (b) The survival curves show significantly more frequent recurrence in patients with BTH or temporal plus extratemporal hypometabolism compared with patients with UTH involving only mesial temporal and temporal pole structures. HS, hippocampal sclerosis; UTH, unilateral temporal hypometabolism; BTH, bilateral temporal hypometabolism.
Subgroup analysis
The subgroup analysis was performed on 208 patients with only unilateral HS. Five years after surgery, BTH (OR, 5.838; 95% CI, 1.195–28.532) and tailoredhippocampal resection (OR, 11.053; 95% CI, 2.306–52.971) independently predicted poor outcomes in the multiple logistic regression (Table 4).
Discussion
We observed surgical outcomes and verified possible prognostic factors in a large group of patients with MTLE during a long-term follow-up period. We found that 85.5% of patients experienced seizure freedom 2 years after MTLE surgery. In the further follow-up period (5 years after surgery) the rate of seizure freedom declined slightly to 83.5%. We demonstrated that neuro-radiological findings, including unilateral HS combined with extra-hippocampal abnormalities, bilateral HS on MRI, and BTH on FDG-PET were independently associated with seizure recurrence. Furthermore, in the subgroup with unilateral HS, BTH predicted a poor long-term outcome.
In past studies, the presence of secondarily generalized seizures before surgery was closely related to postsurgical seizure recurrence,[2,4,5] and some previous studies showed that a long duration of epilepsy was associated with worse outcomes after surgery.[2,26] However, other studies did not find those associations, which has yielded controversy in the literature.[6,7] Among the clinical variables we considered in this study, only the presence of preoperative secondarily generalized seizures had a significant association with short- and long-term outcomes. The duration of epilepsy did not affect outcomes. Our results might stem from the relatively shorter epilepsy duration before surgery among our study population compared with previous studies.
Advances in imaging technologies have improved the detection of brain structural and functional changes related to TLE.[27–29] Extrahippocampal abnormalities in MTLE are not uncommon.[30–34] TLE is a common progressive disease in which the persistent paroxysmal activity during seizures alters highly diffuse, often bilateral, structural brain connectivity. The degree of hippocampal and extrahippocampal brain atrophy might be related to the severity and duration of epilepsy.[31,35] Poor surgical outcomes have been associated with a widespread pattern of preoperative gray matter atrophy in MTLE patients.[36] In our study, unilateral HS combined with extra-hippocampal lesions and bilateral HS on MRI were independently associated with seizure recurrence, compared with unilateral HS. 53 patients (65.5%) with extrahippocampal lesions showed ipsilateral anterior temporal lesions with focal cortical dysplasia in their pathology reports. This finding suggests that the involvement of extrahippocampal structures could be evidence of widespread seizure activity propagation or other aspects of the epileptogenic process.[34,37,38]
Previous studies demonstrated that non-lesional FDG-PET positive patients had outcomes comparable to those of lesional cases after epilepsy surgery.[10,39,40] In our study, 15 patients with MRI-negative TLE who underwent resective surgery experienced favorable results. 86.7% of patients (13 out of 15) with UTH on the preoperative FDG-PET study were seizure free at the 5th year after surgery. But the remaining 2 patients, who had temporal plus extratemporal hypometabolism and BTH on their PET studies, had poor outcomes.
The extent of interictal hypometabolism on FDG-PET could be related to the neuronal networks involved by ictal discharge generation and spread pathways.[41] Although our study did not reveal differences in surgical outcomes between patients with unilateral hypometabolism restricted to the mesiobasal temporal regions and those in whom it extended to the posterolateral temporal region, we did find that BTH was independently associated with seizure recurrence. Some studies looked at functional connectivity in epileptogenic temporal lobe networks and reported that patients with left or right MTLE presented important decreases in connectivity with the contralateral mesial temporal structures.[42–44] In our subgroup analysis of patients with unilateral HS, the patients with BTH presented poor surgical outcomes. Hippocampal change on brain MRI does not appear to determine the existence of metabolic reduction, which suggests that metabolic changes on FDG-PET could precede structural alterations by indicating decreased functional connectivity, and that could be related to more profound neuronal dysfunction.
As one of the complications following anterior temporal lobe surgery, many patients experience various degrees of verbal or non-verbal memory decline.[45] Still, some previous studies showed that the resection extent of the mesial temporal structure correlated positively with surgical outcomes,[46–48] which is in agreement with our results. We found that tailored hippocampal resection was independently associated with seizure recurrence after surgery, even though it was based on intraoperative ECoG results. In contrast, one study found that patients who underwent tailored AH had outstanding outcomes compared with standard surgical procedures, with 66.9% of patients free from disabling seizures (Engel I) and low surgery-related complications.[26]
The distribution of HS types was different from that reported in some studies[49,50], and confirmed that type 1 is the most frequent, whereas CA4-predominant type 3 was rare. Similar to previous study[49], we found no correlation between postoperative outcome and the ILAE hippocampal sclerosis pattern. One recent study has reported the patients with type 2 HS had generally better long-term outcomes than those with type 1.[50] However, we did not observe the similar result that may be due to very small sample sized of type 2 HS in our cases.
We hypothesized that the long and short-term outcomes might be influenced by different factors: seizure recurrence many years after surgery might be associated with different risk factors than those associated with early seizure recurrence.[4] It was interesting that the prognostic factors for short- and long-term outcomes had no difference without bilateral HS on MRI in the present study. In our results, the overall seizure-free rate is excellent, with little difference between the 2nd and 5th year outcomes (Engel class I, 85.5% at the 2nd year after surgery and 83.5% at the 5th year after surgery). Most Engel class IV patients at the 2nd year (12/13, 99.7%) had persisting seizures in the last year of follow-up, which might explain the similarity of our short- and long-term prognostic factors. Although bilateral metabolic reduction was independently associated with poor outcomes in both the short- and long-terms, bilateral HS could not predict short-term poor outcomes. Therefore, BTH might be a more valuable factor for predicting surgical outcome than bilateral HS.
This study has limitations. Our study design was retrospective, with the potential for incomplete data and the bias of unmeasured confounders. We tried to minimize the missing data by applying the same standardized set of presurgical evaluations to patients. The PET images were analyzed semi-quantitatively in a visual analysis, but the degree of inter-observer agreement was high or absolute.
Conclusions
We found that a combination of multiple tests provided highly precise localization of seizure focus and eventually better surgical outcomes. Our results further support the notion that in patients with MTLE and accompanying BTH on FDG-PET but without bilateral MRI changes, surgical suitability should be proved by a more comprehensive work-up. Also, our results might suggest that PET imaging has clinical effectiveness even with concordance between the MRI and electrophysiological data.
Supporting information
S1 Table. Demographics of subjects.
Demographic and clinical assessment data for subjects are included.
https://doi.org/10.1371/journal.pone.0206095.s001
(XLSX)
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