http://orcid.org/0000-0002-7880-6907
Expression of Concern
After publication of this article [1], concerns were raised about the reporting of the methodology, the description and ownership of the dataset used in this study, and the relationship of this article to a previous cross-sectional survey of non-communicable disease risk factors (including hypertension) that sampled a similar population [2]. The PLOS ONE Editors have been unable to contact the authors or Mekelle University to discuss these issues. However, we understand that substantial communication issues have been affecting the region for an extended period.
A statistical advisor reviewed the article [1] and advised that the reporting of the methodological details is incomplete, and that additional information is needed to clarify the sampling and measurement methods, and how the biomedical information was collected. The statistical advisor also noted that the article does not clearly report what variables are included in the logistic regression models, and that no information on collinearity checks is provided. They advised that since the model used is incomplete and not sufficiently adjusted, the conclusion regarding magnitude should be interpreted with caution. It was also noted that the study reported conclusions as to risk factors for hypertension, but as this was a cross-sectional, observational study, conclusions about potential causal relationships are not supported.
In light of the unresolved questions about the dataset and methodology, the PLOS ONE Editors issue this Expression of Concern.
At the time of this notice, the article [1] was republished to address an issue with a Supporting Information file.
Note: in 2019, the authors posted an update to the Acknowledgments and Funding Statement in a Comment on the article’s [1] PLOS ONE webpage.
5 Jan 2023: The PLOS ONE Editors (2023) Expression of Concern: Magnitude and risk factors for hypertension among public servants in Tigray, Ethiopia: A cross-sectional study. PLOS ONE 18(1): e0279946. https://doi.org/10.1371/journal.pone.0279946 View expression of concern
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Abstract
Background
Hypertension is a globally recognized threat to social and economic development with premature morbidity and mortality. In middle and low-income countries hypertension appears to be increasing. However, sufficient data on this silent-killer is not available in Ethiopia. Therefore, this study examined the magnitude and risk factors for hypertension among public servants in Tigray, Ethiopia.
Methods
We used a cross-sectional survey from May-June 2016 among 1525 public servants in Tigray region. Field workers collected data using a pre-tested, standardized questionnaire. A multivariate logistic regression analysis conducted to identify risk factors for hypertension. Statistical significance was declared using a p-value<0.05 and 95% of confidence interval (CI) for an adjusted odds ratio (AOR).
Results
The overall prevalence of hypertension was 16% (95% CI: 13.10–21.9) and the proportion of awareness (96.7%), treatment (31.3%) and control of hypertension (40.1%) among employees. Being male [AOR = 2.06, 95%CI:1.49, 2.84], ages groups of 30–49 years [AOR = 2.21, 95%CI:1.25, 3.89] and >50years [AOR = 3.61, 95% CI:1.93, 6.69], Body Mass Index(BMI); underweight [AOR = 0.40, 95% CI; 0.20, 0.78], overweight [AOR = 1.70, 95%CI; 1.22, 2.33] and obesity [AOR = 3.20, 95% CI; 1.78, 5.78] were determinants for hypertension.
Conclusion
The prevalence of hypertension is relatively high in Mekelle city compared with previous reports. This study revealed that male sex, age-group, and BMI were evidenced as risk factors for hypertension. Policy makers need to consider sector wise integrating prevention and control of hypertension. Skilled based information, education and communication strategies should be designed and implemented to avoid unhealthy lifestyles, investing in workforces to eliminate the modifiable risk factors for non-communicable diseases and promote healthy practices.
Citation: Bayray A, Meles KG, Sibhatu Y (2018) Magnitude and risk factors for hypertension among public servants in Tigray, Ethiopia: A cross-sectional study. PLoS ONE 13(10): e0204879. https://doi.org/10.1371/journal.pone.0204879
Editor: Massimo Ciccozzi, National Institute of Health, ITALY
Received: August 2, 2018; Accepted: September 14, 2018; Published: October 3, 2018
Copyright: © 2018 Bayray et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the manuscript.
Funding: The authors received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
Introduction
Hypertension is the most common single risk factor for cardiovascular related deaths and disability globally [1]. Hypertension is a worldwide silent public-health challenge and a leading modifiable risk factor for non-communicable disease (NCD) and mortality. In 2015 and 2016 W.H.O. report shows that 40 million deaths and more than 70% of mortality worldwide had been caused by NCDs respectively. More than 40% of these deaths were premature and 80% of these deaths from NCDs occur in low and middle-income countries [2]. Hypertension is one of the most frequently observed risk factor for cardiovascular disease (CVD) in Sub-Saharan African [3]. In Sub-Saharan Africa, countries are experiencing an unexpected rise in the incidence of hypertension [1].
By 2030, the number of deaths from NCDs worldwide is projected to increase to 52 million annually [2]. The few studies conducted in Ethiopia are showing a high prevalence of the disease in the country. Approximately, 10.5% of the Ethiopian population and 30% of adults in Addis Ababa has been estimated to have hypertension [4,5]. Another study in Ethiopia showed the overall prevalence of hypertension among adult population to be 27.9%, with the proportion being 30.7% in urban and 25.3% in rural residents. In terms of sex proportion, 29.3% was for women and 26.3% for men [6].
According to WHO 2011 report, the Age-standardized death rate of cardiovascular diseases and hypertension in Ethiopia was estimated to be 473 per 100,000 populations, much higher than that in Japan [7]. Cumulative economic losses associated with the most common NCDs like hypertension, DM in low and middle-income countries are projected to be over $7 trillion during the years 2011–2025, pushing millions of people below the poverty line [8]. Ethiopia has not yet thoroughly studied the epidemiological situation of hypertension nor did they establish systematic programs for prevention and control at a workplace where a sedentary lifestyle and working environment exposes workers more to develop hypertension. Therefore, this study aimed to investigate the magnitude and risk factors for hypertension among public servants in the Tigray Region.
Methods and materials
Study design, area and period
We used a cross-sectional survey to assess the prevalence and risk factors of hypertension among public servants in Tigray from May-August, 2016. Tigray is found in the northern part of Ethiopia. Mekelle is its capital city. Based on the 2007 Census conducted by the Central Statistical Agency of Ethiopia (CSA), the Region has a projected population of 5,151,998, of whom 2,539,997 are male and urban inhabitants 1,331,000. There are more than 20 public offices in the city where an estimated 30,000 public servants are working until the retirement age of 65 years.
Source and study of population
We sampled all adult public servants aged 18–64 years residing in Mekelle city. We excluded pregnant and breastfeeding women from participation in the study.
Sample size determination and sampling procedure
We selected respondents by a random sampling technique stratified by offices based on employee registration records. Purposive (convenient) samplings on a voluntary basis were applied, when randomly selected subjects are not accessible.
Data collection technique and tool
Field workers collected data using a standardized, structured and pre-tested questionnaire [9]. Initially, the questionnaire was prepared in English and translated into Tigrigna (local language). Three trained supervisors and 10 data collectors participated in the data collection process. All of the data collectors had data collection experience in a health survey.
Measurements
We used a standardized questionnaire adapted from the World Health Organization STEPS instrument developed for use in resource-limited countries [9] to collect data on socio-economic characteristics, history of infectious and chronic disease diagnoses, and common risk factors for hypertension including tobacco use, alcohol use, and physical activity. Physical measurements and biochemical measurements were made following a standardized protocol across the study sites. Physical measurements included weight, height and blood pressure.
Blood pressure measurements (BP) were taken on the left arm with the participant in the sitting position using an Arm-Omron digital blood pressure monitor device. The blood pressure of subjects was measured on two different occasions at least 5 minutes apart and the average of the last two blood pressure readings was used for all the subjects. The participants were considered to be hypertensive if they had a systolic blood pressure of ≥140 mmHg and/or a diastolic blood pressure of ≥90 mmHg [10].
Body weight was measured using a bathroom weighing scale that was calibrated for each patient. Subjects were weighed bare-footed in light clothing, the same weighing scale was used for all the subjects and readings expressed in kilograms (kg) to the nearest 0.5kg. Height was also measured with the subjects standing upright, barefooted, back and heel against the wall facing forward using a collapsible standard metal ruler mounted against the wall, while the height was read by placing a ruler at the highest point of the subject’s scalp and expressed to the nearest centimeters. The body mass index (BMI) (kg/m2) was used to define obesity and classified as follows: Underweight = BMI <18.5, Normal weight = BMI 18.5–24.9, Overweight = BMI 25.0–29.9 and Obesity = BMI ≥30.0 [11]. The biochemical measurements were total cholesterol level, HDL cholesterol, LDL cholesterol, and triglycerides. We collected a small amount of peripheral blood sample from the participants and tested it on-spot immediately after the collection.
Data quality assurance
We used a pre-tested structured and standardized questionnaire adopted from WHO STEP [9].
The questionnaire was initially prepared in English[S1 file] and translated into Tigrigna, the local language by a language expert. We gave two days training for data collectors and supervisors. We conducted a pre-test on five percent of the total sample size before the actual data collection.
Data processing and analysis
Data-clerks entered the data into Epi-Info version7.1.5(Center for Disease Control and Prevention, USA) and analyzed using SPSS version 20.0(SPSS Chicago, IL, USA). Bivariate and multivariate logistic regression analysis conducted to assess risk factors for hypertension among public servants at a P-value<0.05, 95% confidence interval and odds ratio.
Ethical considerations
We obtained informed written consent from participants. Data collection was conducted confidentially and data de-identified, de-linked and stored in a secure location. Informed verbal consent was obtained from each subject so that the study could be published and presented at different workshops while protecting the participants’ confidentiality. The informed verbal consent procedure was specifically approved this study by the Institutional Review Board of Mekelle University College of Health Sciences.
Results
Socio-demographic characteristics of respondents
In this study, a total of 1523 respondents were involved, making a response rate of 99.7%. More than half of the respondents, 871(57.2%) were females. The majority of the respondents (65.4%) were in the age group of 30-49years. More than three-fourths, 1451(95.3%) were Orthodox and 953(62.6%) were married. More than 50%, 868(57.0%) respondents had completed college/university education and 823(54.0%) earned of 118.59$US (Table 1).
Behavioral, dietary and bio-medical related characteristics
More than three-fourths of 1134(85.4%) respondents consumed alcohol in the last 30 days and 26(1.7%) ever chat chewier. More than half, 784(51.5%) of respondents reported that they consumed fruits. Roughly, more than two-thirds, 1175(77.5%) of respondents stated that they consumed vegetables and only 52(4.5%) consumed three days or more per week. Almost all 1474(97.2%) respondents were physically inactive. Approximately, one fourth 364(24.3%) of the respondents were overweight and 61(4.1%) obese. Regarding dyslipidemia 385(25.1%) of respondents had raised total cholesterol (> = 200mg/dl), 874(57.3%) raised triglyceride (> = 150mg/dl), 448(29.4%) > = 130mg/dl LDL and 470(30.8%) high HDL cholesterol (Table 2).
Prevalence, awareness, treatment, and control of hypertension
The overall hypertension proportion was 16% (95%CI:13.10, 21.9). Among all hypertensive employees identified, almost all (96.7%) were aware of their hypertension status. However, nearly half, 109(44.9%) of respondents had ever been notified their blood pressure were raised. More than 30% of respondents were taking an anti-hypertensive drug and the overall control rate of hypertension was 40.1% (Table 3).
Factors associated with hypertension among public servants
Sex, age group, and BMI status (underweight, overweight and obesity) were identified as determinants for hypertension among public servants declared with odds ratio and 95% CI in multivariate logistic regression.
The likelihood of being hypertensive was two times more likely higher among male [AOR = 2.06, 95%CI: 1.49, 2.84] compared to their counterparts. Employees in the age groups of 30–49 years [AOR = 2.20, 95%CI: 1.31, 5.07] and ≥50 years [AOR = 3.61, 95%CI: 1.9, 6.69] were two to almost four folds more likely to develop hypertension than those in the age group of 18–29 years.
Moreover, overweight respondents were almost two times [AOR = 1.69, 95%CI:1.22, 2.33] more likely to be hypertensive than participants with normal BMI. Obese respondents were more than three times [AOR = 3.21, 95%CI; 1.78, 5.78] at increased risk of being hypertensive compared with respondents with normal BMI. Whereas underweight participants were 60% less likely [AOR = 0.40, 95% CI; 0.20, 0.78] to develop hypertension (Table 4).
Discussion
This study showed that the proportion of hypertension among public servants to be 16%. Sex, age and BMI status (underweight, overweight and obesity) were determinants for hypertension among public employees.
The prevalence of hypertension was consistent with studies done in southwest Ethiopia (13.2%) [12], Northern Ethiopia (18.1%) [13] and in Aksum town (16.5%) [14]. However, this prevalence is lower than that of studies evidenced in Addis Ababa, Ethiopia (27.3%) [15], Angola (23%) [5] and Kenya (30%) [4]. The observed discrepancies among studies including the present study could be due to study population characteristics and settings difference; the current study included public servants as study subjects whereas almost all the comparative studies were general population.
The study identified the risk factors for hypertension; male employees were two times more likely to develop hypertension compared to female employees. Similar findings have been reported across the low-income countries; a study investigated an adult population in Southern Ethiopia [16] revealed that being a male was a risk factor for hypertension; similarly in young adult Ugandan population [17] and in Brazil men were 49% more likely to have hypertension than women [18]. In the Ethiopian context, men are proxy for common major modified risk factors for tobacco use, alcohol consumption and khat chewing and this is well evidenced in STEPs Survey on risk factors for NCDs and prevalence of selected NCDs, Ethiopia [19]. This could also be due to the high proportion of male employees with hypertension (72%) in the present study.
Employees whose age groups were from 39–49 years and ≥ 50-years were three to nearly five times more likely to have hypertension compared to young age group. This finding is in line with community-based studies conducted in Gondar [20], Bedele [21] and Durame town [16], Ethiopia. Similarly, age has been evidenced as the main predictor of hypertension in low-income countries’ settings such as the Ugandan population [17]. As ages of individuals increase; they could probably be contracted by non-communicable diseases including hypertension. This is reported in studies conducted in a hospital-based and community-based, southwest Ethiopia [12,16,21].
Furthermore, BMI was evidenced as a risk factor for hypertension; those employees who were categorized under over-weight and obesity were more likely to be hypertensive compared to their normal counterparts. This result is consistent with studies conducted in different settings of Ethiopia; in Aksum [14], Gondar [22] and Durame town [16]. A study conducted on adult young Ugandan population has shown that obesity was associated with hypertension [17] and other study conducted in three populations in Africa and Asia (Vietnamese, Indonesian and Ethiopian) also revealed that a significant positive correlation between BMI and blood pressure was also observed [23]. Body mass index (BMI) is usually noted as proxy and mediator factor for hypertension; the observed relationship between overweight, obesity, and hypertension could be due to the difference in dietary habits and physical inactivity of study participants. In this study, significant proportions of public employees were classified under unhealthy diets such as low fruit and vegetable consumption per week and physically inactive. This implies that those individuals who are labeled as overweight or obesity are exposed to major non-communicable diseases. However, underweight was found to be a protective factor for hypertension. This could be because the nutritional status of study participants was measured using BMI which indicates protein energy malnutrition which in turn is explained by underweighted adults being low risks for metabolic syndrome (dyslipidemia) such as raised total cholesterol, triglyceride, LDL and HDL.
Strength and limitation of the study
Data were collected using a pretested and standardized tool (WHO steps). We measured biochemical and physical measurements using digitalized devices. Measurement error (misclassification) was not also observed in this study. This cross sectional study was conducted in urban setting among public servants that did not show the actual burden of hypertension in both rural and urban setting among general populations and was identified as limitation.
Conclusion
The proportion of hypertension is relatively high among public servants in Mekelle city and the figure shows an increase compared with previous reports. This study revealed that sex, age, and BMI were the risk factors for hypertension in the public servants. Policy makers need to consider sector-wise integrated prevention and control measures of hypertension. Appropriate information, education and communication strategies should be designed and implemented to avoid unhealthy lifestyles, investing in workforces to eliminate the modifiable risk factors for hypertension and promote healthy practices. Further research on health seeking behaviors toward hypertension treatment and prevention mechanisms is important so as to formulate possible strategies.
Supporting information
S1 File. English version STEPS_Instrument_V3.1.pdf, 2016.
https://doi.org/10.1371/journal.pone.0204879.s001
(PDF)
Acknowledgments
We are pleased thankful to Mekelle University, sector administrators, and supervisors. We also acknowledge our data collectors and the study participants for giving us paramount information.
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