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Open Access

Correction

Correction: AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

  • Christopher Jakobs,
  • Sven Perner,
  • Veit Hornung

In Fig 1 panel A, the data sets of the control groups (Aim2-/- Dnase2+/+ Ifnar1-/- and Aim2+/+ Dnase2+/+ Ifnar1-/-) are shown as mirror images of the original data. In Fig 2 panel A, the shades of grey in the legend (Aim2-/- Dnase2+/+ Ifnar1-/- and Aim2+/+ Dnase2+/+ Ifnar1-/-) are swapped. In Fig 2 panel B the third and fourth labels are swapped. Please see the correct Figs 1 and 2 here.

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Fig 1. Swelling of joints in the context of Dnase2-deficiency is AIM2-dependent.

A: Aim2+/+ Dnase2-/- Ifnar1-/-, Aim2-/- Dnase2-/- Ifnar1-/-, Aim2+/+ Dnase2+/+ Ifnar1-/- and Aim2-/- Dnase2+/+ Ifnar1-/- mice were scored for joint swelling at indicated time points in a blinded fashion. Statistical significance was assessed using a two-tailed Mann-Whitney test comparing Dnase2-/- cohorts at 8, 12 or 15 months. B: Representative pictures of fore-and hind pads of Aim2+/+ Dnase2-/- Ifnar1-/-, Aim2-/- Dnase2-/- Ifnar1-/-, Aim2+/+ Dnase2+/+ Ifnar1-/- and Aim2-/- Dnase2+/+ Ifnar1-/- mice at the age of 15 month are shown.

https://doi.org/10.1371/journal.pone.0202364.g001

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Fig 2. Systemic proinflammatory status in Dnase2-/- mice is independent of AIM2.

A: Serum was collected from Aim2+/+ Dnase2-/- Ifnar1-/-, Aim2-/- Dnase2-/- Ifnar1-/-, Aim2+/+ Dnase2+/+ Ifnar1-/- and Aim2-/- Dnase2+/+ Ifnar1-/- mice at the age of 15 month and analyzed for the depicted cytokines. B: Spleen weight and representative pictures of spleens from mice at the age of 15 month. C: Relative IFNβ gene expression in spleen tissue normalized to the expression level of HPRT1 is shown. D: Anti-cyclic citrullinated peptide antibody (Anti-CCP-AB) was measured in serum samples as in (A). Data are presented as mean values + SEM, whereas statistical significance was assessed using a two-tailed, unpaired t-test comparing the Dnase2-/- cohorts.

https://doi.org/10.1371/journal.pone.0202364.g002

Reference

  1. 1. Jakobs C, Perner S, Hornung V (2015) AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis. PLoS ONE 10(6): e0131702. https://doi.org/10.1371/journal.pone.0131702 pmid:26114879

Citation: Jakobs C, Perner S, Hornung V (2018) Correction: AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis. PLoS ONE 13(8): e0202364. https://doi.org/10.1371/journal.pone.0202364

Published: August 9, 2018

Copyright: © 2018 Jakobs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.