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Correction: Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage

  • Jui-Hua Hsieh,
  • Ruili Huang,
  • Ja-An Lin,
  • Alexander Sedykh,
  • Jinghua Zhao,
  • Raymond R. Tice,
  • Richard S. Paules,
  • Menghang Xia,
  • Scott S. Auerbach

The images for Figs 2 and 3 are incorrectly switched. The image that appears as Fig 2 should be Fig 3 and the image that appears as Fig 3 should be Fig 2. The figure captions appear in the correct order.

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Fig 2. Examples of two chemicals (digitonin vs. mitomycin C) with different kinetics of cytotoxicity.

Blue: HEK293; red: HepG2. Filled circle (glo); hollow circle (flor); the arrow represents the earliest time interval where the maximum cytotoxic effect was obtained (filled arrow head: glo; hollow arrow head: flor).

https://doi.org/10.1371/journal.pone.0181291.g001

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Fig 3. Comparison of number of actives in four assays.

The number of actives detected in the four assays at the six different time points. Blue: HEK293 cell line; red: HepG2 cell line. Filled circle: glo assay technology; hollow circle: flor assay technology.

https://doi.org/10.1371/journal.pone.0181291.g002

Reference

  1. 1. Hsieh J-H, Huang R, Lin J-A, Sedykh A, Zhao J, Tice RR, et al. (2017) Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage. PLoS ONE 12(5): e0177902. https://doi.org/10.1371/journal.pone.0177902 pmid:28531190