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Open Access

Correction

Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor

  • Yayoi Yoshimura,
  • Akihiko Shiino,
  • Kazue Muraki,
  • Tadateru Fukami,
  • Shigeki Yamada,
  • Takeshi Satow,
  • Miyuki Fukuda,
  • Masaaki Saiki,
  • Masato Hojo,
  • Susumu Miyamoto,
  • Nobuyuki Onishi,
  • Hideyuki Saya,
  • Toshiro Inubushi,
  • Kazuhiko Nozaki,
  • Kenji Tanigaki

Fig 7 is incorrect. Panel E was incorrectly labeled. The authors have provided a corrected version here.

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Fig 7. Arsenic trioxide and 10058F4 combination treatment efficiently regressed established gliomas.

Experimental Design. GBM CSCs (RI03) CSCs (5 × 104 cells) were implanted intracranially into SCID mice. Two months after transplantation, tumor growth was monitored by MRI. Four days after tumor size measurement, Arsenic Trioxide (2.5 mg/kg), 10058F4 (25mg/Kg) or both were administered by i.p. injection once a day for 10 days. After 10-day drug treatments, tumor sizes were again measured. Representative images of T2-weighted MRI. The region of interest used to calculate the volume of brain tumor is indicated by a dashed line. (C)-(D) Representative photographs of hematoxylin / eosin staining of intracranial xenograft brain tumors. The boxed area in (C) is magnified in (D). Scale bar = 500μm. (E)-(F) Changes in tumor volume after 10-day treatment with arsenic trioxide and 10058F4 relative to the starting tumor volume for each individual mouse. Each bar represents a volume change of an individual mouse. The data in (E) is shown as the mean ± SD of the data for each individual mouse in (F).

https://doi.org/10.1371/journal.pone.0149826.g001

Reference

  1. 1. Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, et al. (2015) Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor. PLoS ONE 10(6): e0128288. pmid:26038891

Citation: Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, et al. (2016) Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor. PLoS ONE 11(2): e0149826. https://doi.org/10.1371/journal.pone.0149826

Published: February 16, 2016

Copyright: © 2016 Yoshimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.