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Open Access

Correction

Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies

  • Xiangying Guan,
  • Ping Lin,
  • Eric Knoll,
  • Raj Chakrabarti

Correction

14 Sep 2015: The PLOS ONE Staff (2015) Correction: Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies. PLOS ONE 10(9): e0138393. https://doi.org/10.1371/journal.pone.0138393 View correction

The authors would like to provide the expressions for K1,K2,K3, Km,NAD+ and vmax for Equation 3, which should have been included as a supplementary file with the article.

The expressions for K1,K2,K3,Km,NAD+ and vmax are provided in S1 File in this Correction.

For sirtuins, kcat<< kj, j ≠ cat does not imply Km, NAD+ ≈ Kd, NAD+; see S1 File.

Supporting Information

S1 File. Initial rate model for sirtuin deacetylation kinetics.

https://doi.org/10.1371/journal.pone.0136127.s001

(PDF)

Reference

  1. 1. Guan X, Lin P, Knoll E, Chakrabarti R (2014) Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies. PLoS ONE 9(9): e107729. pmid:25221980

Citation: Guan X, Lin P, Knoll E, Chakrabarti R (2015) Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies. PLoS ONE 10(8): e0136127. https://doi.org/10.1371/journal.pone.0136127

Published: August 14, 2015

Copyright: © 2015 Guan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited