A. Eye axial length in wild-type zebrafish has a good linear relationship to body axis length with points close to the best-fit trendline. lrp2 zebrafish axial length:body length ratios are mostly longer than wild-type, and show less correlation with the best-fit line. B. Eye axial length in wild-type zebrafish has an excellent linear relationship with lens diameter, while lrp2 zebrafish axial length:lens diameter ratios show less correlation with the best-fit line. C. Images of wild-type and lrp2 mutant zebrafish at 2 mpf. At this age, the lrp2 enlarged eye phenotype is not always obvious, and one fish can have emmetropic eye growth (lrp2 (normal eye size)) while another has enlarged, myopic eyes, with the left eye more affected than the right (lrp2 (large eye size)). OCT images of each eye are shown. D. Measurements taken from OCT images for each eye in C, as well as relative refractive error showing that only the lrp2 (large eye size) fish is myopic at this time.

https://doi.org/10.1371/journal.pone.0119779.g001