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Correction

Correction: Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII α in Epileptic Hippocampal Neurons

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“Normal group” should read “Control group” in Figures 1, 2, 3 and 4. Figure 4 is incorrect, only Figure 4A was published and Figure 4B was incorrectly omitted. The authors have provided a corrected version of Figures 1, 2, 3 and 4 here.

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Figure 1. Changes in fluorescence intensity of Ca2+ in neurons during establishment of the model, n  =  4, thirty neurons were observed in each replicate.

There is a significant increase (within 30 seconds) in fluorescence intensity of Ca2+ in neurons in the model group compared to the control group (p<0.001). This increase also occurs in the GLP I group, and it decreases in both Model and GLP I groups with time up to 10 minutes when the Model group is still significantly higher than the Control group I, but, there is no difference between the Control group I and GLP I groups at 10 minutes. Tukey’s test following one way ANOVA was used to perform statistical analysis.

https://doi.org/10.1371/journal.pone.0102161.g001

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Figure 2. Changes in fluorescence intensity of Ca2+ in neurons during the treatment, n  =  4, thirty neurons were observed in each replicates.

There is no change in fluorescence intensity of Ca2+ in neurons in the Control group II during a 3 hour period. Fluorescence intensity of Ca2+ in neurons was highest in neurons cultured in Mg2+ ion free medium for 3 hours prior to replacement with normal maintaining medium i.e. Model group II; there is no significant decrease (P>0.05) between the zero time point (0 hour) and 3 hours following the normal medium replacement. However, following GLP treatment, there is a gradual decrease in Fluorescence intensity of Ca2+ in neurons, with levels almost returning to normal after 3 hours. Tukey’s test following one way ANOVA was used to perform statistical analysis.

https://doi.org/10.1371/journal.pone.0102161.g002

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Figure 3. The fluorescence intensity of CaMK II α protein in hippocampal neurons in Control group III (A), Model group III (B), GLP group III (C) and IV (D).

Data shown as mean±SD, n  =  4. Corresponding, representative images are shown in Images S4A, S4B, S4C and S4D. Tukey’s test following one way ANOVA was used to perform the statistical analysis. #compared to Control group III, p<0.01; *compared to Model group III, p<0.01.

https://doi.org/10.1371/journal.pone.0102161.g003

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Figure 4. CaMK II α protein expression.

Relative amount of CaMK II αprotein expressed in neurons in different groups (A) and Western blot analysis (B) of neurons from each untreated/treated group. Data in figure 4A is shown as mean±SD, n  =  4. Tukey’s test following one way ANOVA was used to perform the statistical analysis. #indicated p<0.01, compared to Control group III; *indicated p<0.01, compared to Model group III.

https://doi.org/10.1371/journal.pone.0102161.g004

Reference

  1. 1. Wang S-Q, Li X-J, Qiu H-B, Jiang Z-M, Simon M, et al. (2014) Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII α in Epileptic Hippocampal Neurons. PLoS ONE 9(7): e102161

Citation: The PLOS ONE Staff (2014) Correction: Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII α in Epileptic Hippocampal Neurons. PLoS ONE 9(10): e111295. https://doi.org/10.1371/journal.pone.0111295

Published: October 10, 2014

Copyright: © 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.