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Open Access

Correction

Correction: The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence

  • The PLOS ONE Staff

The original orientation of the western blot in Figure 3A was incorrect. The authors have provided a corrected version of Figure 3 here.

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Figure 3. Hypoxia-driven inhibition of expression of hallmarks of senescence is Hif-1α dependent.

shRNA_HIF-1α and shRNA_scr (a scrambled shRNA sequence encoding plasmid used as negative control) expressing IMR-90 and BJ cells were infected with H-RasV12 and selected for puromycin for 3 days. Three days post exposure to hypoxia cells were analyzed for A. the expression of HIF-1α by western-blotting, β-actin was used as loading control; B. for mRNA level by Quantitative RT-PCR; C. the expression of senescence regulators p53, p21CIP1, p16INK4a and MIF by western-blotting. β-actin was used as loading control. Statistically significant differences between mRNA levels of HIF-1α in Ras + shNC vs. Ras+ shHIF-1α expressing cells in hypoxia are indicated *, p<0.01. Shown are means ± SD of 3 independent experiments in triplets.

https://doi.org/10.1371/journal.pone.0101064.g003

Reference

  1. 1. Kilic Eren M, Tabor V (2014) The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence. PLoS ONE 9(7): e101064

Citation: The PLOS ONE Staff (2014) Correction: The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence. PLoS ONE 9(10): e110981. https://doi.org/10.1371/journal.pone.0110981

Published: October 8, 2014

Copyright: © 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.