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Open Access

Correction

Correction: Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies

  • The PLOS ONE Staff

The first sentence of the sub-section “DBH secretion into plasma” of the Results is incorrect. The correct sentence is: Across biogeographic ancestries (white versus black), we found that DBH plasma activity substantially decreased with increasing copy number (0,1,2 per genome) for haplotype-2 (C→T), with a directionally opposite effect for haplotype-3 (T→C) (Figures 3b, 3c).

The last two sentences of the third paragraph of the “DBH functional genetic variation and renal function” sub-section of the Discussion should be deleted.

There are a number of errors in Figure 3. Please see the corrected Figure 3 here.

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Figure 3. DBH promoter haplotypes (C-2073T→C-970T): Results for haplotype/luciferase reporter enzymatic activity in transfected chromaffin cells, as well as DBH secretion in humans.

a. DBH promoter haplotype expression in the nucleus: Transcription in luciferase reporter plasmids transfected into chromaffin (PC12) cells. Each promoter transfection was done in 8 replicates. b. DBH promoter haplotypes in vivo: Effects on plasma DBH activity. Two functional promoter SNPs constituting a haplotype are shown in subjects of European ancestry, African American and the overall population. Haplotype-2 (C→T) is significantly associated with DBH activity in subjects from European ancestry as well as the overall study population. c. Haplotype-3 (T→C) is significantly associated with DBH activity in all groups. d. Common promoter variants C-2073T and C-970T analyzed individually for effects on DBH secretion in vivo. Plasma DBH activity shows significant association with each of the common variants, both C-2073T and C-970T. To attain specificity, C-2073T or C-970T (as appropriate) were included as covariates, along with age and sex.

https://doi.org/10.1371/journal.pone.0082956.g003

Reference

  1. 1. Pasha DN, Davis JT, Rao F, Chen Y, Wen G, et al. (2013) Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies. PLoS ONE 8(12): e82956

Citation: The PLOS ONE Staff (2014) Correction: Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies. PLoS ONE 9(6): e100351. https://doi.org/10.1371/journal.pone.0100351

Published: June 16, 2014

Copyright: © 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.