Retraction
Following the publication of this article [1] concerns were raised about similarity with content in previously published articles [2–4] by the same group. The PLOS One Editors followed up with the authors and corresponding author CXY indicated that the following article content was previously published:
- The expression of recombinant Schistosoma japonicum thioredoxin glutathione reductase (SjTGR) was reported in [2].
- The reported thioredoxin reductase (TrxR), glutathione reductase (GR) and glutaredoxin (Grx) activities of the recombinant SjTGR in Table 1 of [1] are the same as those in Table 1 of [2].
- Fig 1 in [1] was previously published as Figure 1 in [2].
- Fig 2 in [1] was previously published as the left panel in Figure 2 in [2].
- Fig 3 in [1] was previously published as Figure 3 in [2].
- Fig 4 in [1] was previously published as the right panel in Figure 2 in [2], and as Figure 1 in [3].
- Fig 5 in [1] was previously published as Figure 4 in [2].
- Figs 6A-C in [1] were previously published as Figures 2-4 in [3].
- Figs 7A-C in [1] were previously published as Figure 1-3 in [4].
- Tables 1-3 in [1] report the same results as Tables 1-3 in [3].
- The paragraph titled “Toxicity of auranofin in cultured S. japonicum adult worms” in the Results section of [1] reports the same results previously described in [4].
- Articles [2–4] were not cited in [1].
Corresponding author CXY stated that [3] discusses the enzymatic characteristics of the recombinant TGR protein; [2–4] report a comprehensive study on the thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR), including gene cloning, construction of selenium protein expression vector, expression and purification of recombinant SjTGR protein, enzymatic characteristic analysis, inhibitor screening in vitro and therapeutic experiments in vivo; and [1] combines the studies reported in [2–4]. Corresponding author CXY also stated that Table 4 reporting reduction of worm and egg numbers in vivo following auranofin treatment were not reported prior to the publication of [1].
Corresponding author CXY apologizes for the issues with the published article [1] and stated that the dual publication arose owing to CXY’s unfamiliarity with the rules of international journal publication at that time. Authors CXY, ZCH, and JHL stated that ZCH and JHL were not aware of the publication of [3].
In light of the above concerns which call into question the compliance of [1] with PLOS One’s publication criteria that results reported have not been published elsewhere [5], the PLOS One Editors retract this article.
LJS, JHL, ZCH, and CXY agreed with the retraction. SYX, CYQ, JW, WZ, and XRY either did not respond directly or could not be reached.
The retracted article [1] was removed from the PLOS One website at the time of retraction, due to the similarities with [2–4]. The article’s Copyright statement was also updated at that time, and the removed contents are no longer offered under the Creative Commons Attribution License.
31 Mar 2026: The PLOS One Editors (2026) Retraction: Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum. PLOS ONE 21(3): e0346111. https://doi.org/10.1371/journal.pone.0346111 View retraction
Citation: Song L, Li J, Xie S, Qian C, Wang J, Zhang W, et al. (2012) RETRACTED: Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum. PLoS ONE 7(2): e31456. https://doi.org/10.1371/journal.pone.0031456
Editor: Jianghong Rao, Stanford, United States of America
Received: April 8, 2011; Accepted: January 8, 2012; Published: February 22, 2012
Copyright: © 2012 Song et al. Due to the similarity of this article with a previously published work, the article contents were removed from PLOS One at the time of retraction. Readers are hereby on notice that the removed contents are not offered under the Creative Commons Attribution License; see the accompanying retraction notice for details.
Funding: This work was supported by the National Natural Science Foundation of China (30972581, 50973046, 30821006), the National Key Basic Research Program in China (2007CB513100, 2011CB933502), the Natural Science Foundation of Jiangsu Province (BK2008110, BK2010046) and the Special Fund for Public Interest of Science and Technology Department in Jiangsu Province (BM2007704). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.