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Correction: Structure-Activity Relationships of Constrained Phenylethylamine Ligands for the Serotonin 5-HT2 Receptors

  • Vignir Isberg,
  • James Paine,
  • Sebastian Leth-Petersen,
  • Jesper L. Kristensen,
  • David E. Gloriam
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In the last paragraph of the Results section under the heading 'Differences in the binding site may explain the lower affinity of 8−11 in 5-HT2A and higher affinity of 10−11 in 5-HT2B', the second sentence is incorrect. The correct sentence is: This position is occupied by a methionine in 5-HT2B, but an valine in 5-HT2A and 5-HT2C (Fig. 7a-c). In the second paragraph of the Methods section under the heading 'Ligand docking into the 5-HT2B crystal structure', the second to last sentence is incorrect. The correct sentence is: The binding sites of the 5-HT2 receptor subtypes deviate only in two residue positions: 5.46 (5-HT2A: S, 5-HT2B: A and 5-HT2C: A) and 5.39 (5-HT2A: V, 5-HT2B: M and 5-HT2C: V). In the final paragraph of the Methods section, under the heading "Conformational penalties for strained ligand poses", the following sentence should be added as the last sentence of that paragraph: Marvin was used for drawing 2D structures (Marvin 5.12.3, 2013, ChemAxon, www.chemaxon.com) and 3D structures were illustrated using Pymol (PyMOL Molecular Graphics System, Version 1.5.0.4 Schrödinger, LLC). Figure 7 is incorrect. The correct version of Figure 7 can be viewed here: