Peer Review History
| Original SubmissionAugust 30, 2025 |
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PONE-D-25-46495From Knowledge to Judgment: Tracking LLM Progress on the Chinese National Nurse Licensing Examination Over Three Years.PLOS ONE Dear Dr. Chen, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. Please submit your revised manuscript by Jan 09 2026 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. We look forward to receiving your revised manuscript. Kind regards, Krit Pongpirul, MD, MPH, PhD. Academic Editor PLOS ONE Journal requirements: When submitting your revision, we need you to address these additional requirements. 1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and 2. Please note that PLOS One has specific guidelines on code sharing for submissions in which author-generated code underpins the findings in the manuscript. In these cases, we expect all author-generated code to be made available without restrictions upon publication of the work. Please review our guidelines at https://journals.plos.org/plosone/s/materials-and-software-sharing#loc-sharing-code and ensure that your code is shared in a way that follows best practice and facilitates reproducibility and reuse. 3. Please include your tables as part of your main manuscript and remove the individual files. Please note that supplementary tables (should remain/ be uploaded) as separate "supporting information" files. 4. Thank you for stating the following financial disclosure: [This work was supported by the Zhejiang Provincial Natural Science Foundation of China (Grant No. LQ24H160021) and Zhejiang medical and health project (Grant No. 2023KY781).]. Please state what role the funders took in the study. If the funders had no role, please state: "The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." If this statement is not correct you must amend it as needed. Please include this amended Role of Funder statement in your cover letter; we will change the online submission form on your behalf. 5. In the online submission form, you indicated that [Available from the corresponding author upon reasonable request.]. All PLOS journals now require all data underlying the findings described in their manuscript to be freely available to other researchers, either 1. In a public repository, 2. Within the manuscript itself, or 3. Uploaded as supplementary information. This policy applies to all data except where public deposition would breach compliance with the protocol approved by your research ethics board. If your data cannot be made publicly available for ethical or legal reasons (e.g., public availability would compromise patient privacy), please explain your reasons on resubmission and your exemption request will be escalated for approval. 6. PLOS requires an ORCID iD for the corresponding author in Editorial Manager on papers submitted after December 6th, 2016. Please ensure that you have an ORCID iD and that it is validated in Editorial Manager. To do this, go to ‘Update my Information’ (in the upper left-hand corner of the main menu), and click on the Fetch/Validate link next to the ORCID field. This will take you to the ORCID site and allow you to create a new iD or authenticate a pre-existing iD in Editorial Manager. 7. Please include a copy of Table 1-3 which you refer to in your text on page 22. 8. If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise. Additional Editor Comments: Please carefully address the responses from both reviewers, particularly the concerns regarding authorship and funding. [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Yes Reviewer #2: Partly ********** 2. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: Yes Reviewer #2: Yes ********** 3. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: Yes Reviewer #2: Yes ********** 4. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #2: Yes ********** 5. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: Funding Statement Contradiction The manuscript declares in the “Funding” section (line 504) that “This research received no specific grant funding,” yet the submission form explicitly states it was supported by two Chinese grants (Zhejiang Provincial Natural Science Foundation No. LQ24H160021 and Zhejiang Medical and Health Project No. 2023KY781). This discrepancy must be resolved—either the funding statement is inaccurate, or the submission form was misreported. Inadequate Data Availability Compliance Although the authors affirm in the submission form that “all data are fully available without restriction,” the manuscript’s Data Availability statement reads: “Available from the corresponding author upon reasonable request.” This phrasing violates PLOS ONE’s data policy, which requires public, immediate access (e.g., via a repository with DOI) unless a rare legal/ethical exception applies—which is not claimed here. Authorship and Contributor Mismatch The “Authors’ Contributions” section lists individuals with initials “T-TY” and “X-LH” (lines 507–508), but these do not correspond to any of the four named authors (Xinju Zhan, Weihua Yu, Jianshu Cai, Jionghuang Chen). This raises concerns about ghost authorship or a copy-paste error that must be corrected for transparency and accountability. Ethics Statement Inconsistency The online submission form marks the Ethics Statement as “N/A,” but the manuscript describes IRB exemption (#2024-NURS-089) from Sir Run Run Shaw Hospital. Since the study used publicly available exam questions and no human subjects, an exemption is appropriate—but the submission form must reflect this, not “N/A.” Unsubstantiated Passing Threshold Claim The authors equate 60% raw accuracy with passing the Chinese National Nurse Licensing Examination (which uses a 300-point scaled score). However, they provide no evidence linking raw percentage correct to the official scaled passing standard. Without validation from the National Medical Examination Center (NMEC), the claim that models “pass” the exam is potentially misleading. Ambiguous Temporal Evaluation Protocol While the study claims “temporal fidelity” (testing models only on exams released after their launch), it lacks specifics: Which exact model versions were used? Were mid-year updates (e.g., GPT-4 vs. GPT-4o) accounted for? Without a clear timeline mapping models to exam dates, the longitudinal validity is weakened. Overstatement of Clinical Competence Phrases like “sufficient codified nursing knowledge to pass professional licensing examinations” may imply clinical readiness. Yet the study itself shows that 43% of errors involve clinical reasoning failures and 27% involve prioritization mistakes—critical gaps in real-world care. The conclusion should more clearly emphasize that exam performance ≠ safe clinical judgment. Missing Inference Protocol Details The evaluation used “standardized zero-shot prompting,” but key parameters (e.g., temperature, top-p, max tokens, API vs. local inference) are not reported. These choices significantly affect LLM outputs, especially for open models like Llama 3, and must be disclosed for reproducibility. Unclear Copyright and Redistribution Status of Question Corpus While questions were sourced from public platforms (e.g., 21wecan.com), it is unclear whether the compiled 7,200-question dataset can be legally shared. If derived from copyrighted prep materials, public redistribution may not be permissible—requiring either repository deposition with proper licensing or clarification of public-domain status. Reviewer #2: This report provides a comprehensive review of the manuscript titled “From Knowledge to Judgment: Tracking LLM Progress on the Chinese National Nurse Licensing Examination Over Three Years”. The study addresses a relevant and timely topic with practical implications. However, the introduction section requires a thorough clarification of theoretical framework of the study. Also, the AI systems are mentioned in many parts of the research but not prominent in the title, this raises some concerns to me, refining of the title or the writing may be required. Regarding the introduction section, it lacks a clear theoretical framework. Also, the lines 97-98, more clarification or definition is needed for the examples of Chinese- native LLMs. Concerning the methodology section, line 144-146, clarify if these domains are the only official domain studied in the Chinese nursing institutions, if not, why other domains as nursing administration or critical care nursing are not included in the exam and the study. Line 166, kindly, give example to clearly define the concept of zero-shot prompting protocols. In regard to the results section, it was concise, clear and to the point. Concerning the discussion section, in my opinion, it will be better to add a researchers’ point of view regarding the nursing licensing examinations internationally at the end, of course. Line 457-461, I think it would be good to transfer these lines to the conclusion and practical recommendation sections. Regarding the conclusion section, it is concise and to the point. However, it needs clarification for the nursing profession and for the nursing practice. ********** 6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: Yes: Dr. Mohammad Abuadas Reviewer #2: Yes: Dr. Lareen Magdi El-Sayed Abo-Seif ********** [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] To ensure your figures meet our technical requirements, please review our figure guidelines: https://journals.plos.org/plosone/s/figures You may also use PLOS’s free figure tool, NAAS, to help you prepare publication quality figures: https://journals.plos.org/plosone/s/figures#loc-tools-for-figure-preparation. NAAS will assess whether your figures meet our technical requirements by comparing each figure against our figure specifications. |
| Revision 1 |
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PONE-D-25-46495R1 From Knowledge to Judgment: A Three-Year Longitudinal Analysis of Artificial Intelligence Large Language Model Performance on the Chinese National Nurse Licensing Examination PLOS One Dear Dr. Chen, Thank you for submitting your manuscript to PLOS ONE. I appreciate the depth of your engagement with reviewer feedback. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points below:
Please submit your revised manuscript by Jul 04 2026 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. As the corresponding author, your ORCID iD is verified in the submission system and will appear in the published article. PLOS supports the use of ORCID, and we encourage all coauthors to register for an ORCID iD and use it as well. Please encourage your coauthors to verify their ORCID iD within the submission system before final acceptance, as unverified ORCID iDs will not appear in the published article. Only the individual author can complete the verification step; PLOS staff cannot verify ORCID iDs on behalf of authors. We look forward to receiving your revised manuscript. Kind regards, Isaac Amankwaa, Ph.D. Academic Editor PLOS One Journal Requirements: 1. If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise. 2. Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice. [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #2: All comments have been addressed Reviewer #3: (No Response) ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #2: Yes Reviewer #3: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #2: Yes Reviewer #3: (No Response) ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #2: Yes Reviewer #3: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #2: Yes Reviewer #3: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #2: (No Response) Reviewer #3: Major Issues Methods insufficiently described — Dataset source, prompting strategy, and reproducibility details are unclear. Possible data leakage not adequately addressed. Overinterpretation of results — Exam performance should not be equated with clinical competence. Statistical methods need clarification (assumptions, multiple comparisons). Error analysis is strong but requires explanation of coding procedures and reviewer reliability. Minor Issues Reduce speculative language in results. Improve figure/table clarity. Add ethical considerations regarding clinical AI use. Additional Suggestion: Related Work Updates To strengthen the literature review with recent advancements, please consider discussing and adding the following highly relevant recent papers to your reference list: https://arxiv.org/pdf/2605.00224 https://arxiv.org/pdf/2409.14563 https://openreview.net/pdf?id=EehtvgNXAl https://arxiv.org/pdf/2510.12178 ********** 7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #2: Yes: Dr. Lareen Magdi El-Sayed Abo-Seif Reviewer #3: No ********** [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] To ensure your figures meet our technical requirements, please review our figure guidelines: https://journals.plos.org/plosone/s/figures You may also use PLOS’s free figure tool, NAAS, to help you prepare publication quality figures: https://journals.plos.org/plosone/s/figures#loc-tools-for-figure-preparation. NAAS will assess whether your figures meet our technical requirements by comparing each figure against our figure specifications. |
| Revision 2 |
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From Knowledge to Judgment: A Three-Year Longitudinal Analysis of Artificial Intelligence Large Language Model Performance on the Chinese National Nurse Licensing Examination PONE-D-25-46495R2 Dear Dr. Chen, We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements. Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication. An invoice will be generated when your article is formally accepted. Please note, if your institution has a publishing partnership with PLOS and your article meets the relevant criteria, all or part of your publication costs will be covered. Please make sure your user information is up-to-date by logging into Editorial Manager at Editorial Manager® and clicking the ‘Update My Information' link at the top of the page. For questions related to billing, please contact billing support. If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org. Kind regards, Isaac Amankwaa, Ph.D. Academic Editor PLOS One Additional Editor Comments (optional): Reviewers' comments: |
| Formally Accepted |
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PONE-D-25-46495R2 PLOS One Dear Dr. Chen, I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS One. Congratulations! Your manuscript is now being handed over to our production team. At this stage, our production department will prepare your paper for publication. This includes ensuring the following: * All references, tables, and figures are properly cited * All relevant supporting information is included in the manuscript submission, * There are no issues that prevent the paper from being properly typeset You will receive further instructions from the production team, including instructions on how to review your proof when it is ready. Please keep in mind that we are working through a large volume of accepted articles, so please give us a few days to review your paper and let you know the next and final steps. Lastly, if your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org. You will receive an invoice from PLOS for your publication fee after your manuscript has reached the completed accept phase. If you receive an email requesting payment before acceptance or for any other service, this may be a phishing scheme. Learn how to identify phishing emails and protect your accounts at https://explore.plos.org/phishing. If we can help with anything else, please email us at customercare@plos.org. Thank you for submitting your work to PLOS ONE and supporting open access. Kind regards, PLOS ONE Editorial Office Staff on behalf of Dr. Isaac Amankwaa Academic Editor PLOS One |
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