Peer Review History

Original SubmissionDecember 19, 2025
Decision Letter - Gisele Viana de Oliveira, Editor

-->PONE-D-25-63882-->-->Who Becomes a Dermatologist? A Cross-Sectional Study on Diversity in the Dutch Dermatology Workforce-->-->PLOS One

Dear Dr. Mulder

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Gisele Viana de Oliveira

Academic Editor

PLOS One

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Reviewers' comments:

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #2: Yes

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Reviewer #1: This study assesses diversity in the Dutch dermatology workforce, focusing on sex, migration background, and socioeconomic status. Data from the BIG register (2005-2023) reveal significant increases in female dermatologists (61.7% in 2023), but ethnic diversity remains stagnant. Regression analyses show that being female, having wealthy or physician parents increases the likelihood of becoming a dermatologist.

This is a timely and relevant paper.

Minor comments:

- The paper touches on socioeconomic status and family background but could expand on intersectionality: how socioeconomic and ethnic backgrounds intersect to impact dermatology career progression.

- The lack of data for small groups (<5 individuals) in some regression models limits the analysis. Please briefly discuss how this was dealt with.

Some spelling mistakes (" recruitmenent, microdataconducting, sociaal-economic etc.). Please revise.

Reviewer #2: This manuscript addresses an important and timely issue regarding workforce diversity in Dutch dermatology. The use of nationwide registry data spanning nearly two decades is a clear strength, and the analytical approach is appropriate for the research questions posed. The topic is highly relevant for health workforce research and for ongoing discussions about equity in medical specialties. That said, several aspects of reporting and interpretation would benefit from refinement.

With respect to the abstract, it is generally clear and structured, but it could better align with reporting recommendations for observational studies (STROBE). First, the study design should be explicitly stated early in the abstract. At present, the data source and analytical approach are described, but the design is not clearly identified as a nationwide repeated cross-sectional study. Including this explicitly would immediately clarify the methodological framework. Second, the comparison group in the regression analysis should be more clearly defined. It would improve transparency to specify that dermatologists were compared with the broader physician workforce registered in the national registry. Third, the Results section of the abstract summarizes regression findings narratively; if space allows, including at least one adjusted odds ratio with its confidence interval would strengthen quantitative reporting. Finally, the concluding sentence should be moderated slightly to avoid implying causal effects on patient care, given the cross-sectional design. Framing the implications as potential or exploratory would enhance scientific precision.

Beyond the abstract, the overall methodology is sound and the statistical analyses are appropriately conducted, including assessment of multicollinearity. The use of parental asset percentiles and parental profession as socioeconomic indicators is thoughtful and yields interesting findings. However, the interpretation of these associations should be more cautious. The study identifies demographic characteristics associated with being registered as a dermatologist, but it does not include data on residency applications, acceptance rates, specialty preferences, or academic performance. As such, it cannot determine whether observed disparities reflect structural barriers, self-selection, intergenerational professional transmission, or other mechanisms. The Discussion occasionally moves beyond the data in suggesting inequitable access or exclusion; these statements should be tempered and clearly framed as hypotheses requiring further study.

Similarly, while the manuscript raises important concerns about potential implications for equitable dermatologic care, the study does not evaluate patient outcomes, diagnostic accuracy, or access to care in the Netherlands. Extrapolations from international literature are informative, but conclusions about clinical impact should be presented as areas for future research rather than direct consequences of the findings.

The policy recommendation for a centralized residency selection system is thought-provoking but currently exceeds the direct evidence provided by the analyses. As the study does not examine selection procedures themselves, these recommendations should be presented more cautiously.

Conceptually, a brief expansion on the limitations of using “migration background” based on parental country of birth would strengthen the theoretical framing, as this classification may not fully capture lived cultural or linguistic experience.

Overall, this is a valuable and well-executed study that contributes meaningful national data to an underexplored European context. The primary revisions required concern clarity of reporting in the abstract and greater interpretive restraint in the Discussion. With these adjustments, the manuscript would be considerably strengthened and well suited for publication.

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Reviewer #1: Yes:  Mahdi Salih

Reviewer #2: Yes:  Gabriel Lazzeri Cortez

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Revision 1

Dear Editor and Reviewers,

We would like to sincerely thank the Academic Editor and both reviewers for their thoughtful and constructive feedback on our manuscript. We are grateful for the positive reception of our work and greatly appreciate the valuable suggestions for improvement. We have carefully addressed each comment to the best of our ability and believe the revisions have strengthened the manuscript considerably. Below, we provide a detailed overview of all feedback received and the corresponding changes made.

Reviewer 1 (Mahdi Salih)

Spelling and language errors: The reviewer noted some spelling mistakes (e.g., "sociaal-economic", "microdataconducting") and suggested revision. Our response: We have carefully proofread the entire manuscript and corrected all identified spelling and language errors. Specifically, we corrected "sociaal-economic" to "socio-economic" throughout and standardized all instances to the hyphenated form. We also corrected "medial doctors" to "medical doctors," changed "between 2005 to 2023" to "from 2005 to 2023," replaced Dutch decimal notation (commas) with English decimal points throughout the Results section, and corrected "less than" to "fewer than" where appropriate for countable quantities.

Intersectionality: The paper could expand on how socio-economic status and family background intersect with ethnic background to impact dermatology career progression. Our response: We have added a new paragraph to the Discussion that explicitly addresses intersectionality. Drawing on recent literature (Samra and Hankivsky, 2021; Mosley et al., 2025; Nguyen et al., 2024), we discuss how migration background, socio-economic status, and sex do not operate as independent barriers but compound one another. We also reference a recent Dutch study among medical residents (Al-Hassany et al., 2025) and connect these findings to our own intersectional analyses, which show that workforce growth was overwhelmingly concentrated among women without a migration background.

Small group limitation: The lack of data for small groups (<5 individuals) in some regression models limits the analysis. Please briefly discuss how this was dealt with. Our response: We have expanded the Methods and Limitations section to clarify that we included all groups of physicians in the regression analyses, but that we were not allowed to publish the regression results if there were fewer than 5 dermatologists in the specific group. This means that the analysis was not limited in any way (as physicians were not excluded from the regression analysis itself) but only that the outcome could not be published in the manuscript if there were fewer than 5 dermatologists with a specific background. In the Limitations section, we have changed the existing paragraph to: "Lastly, the small size of certain demographic groups in our intersectional analysis presents another limitation. Statistics Netherlands prohibits reporting descriptive statistics for groups with <10 individuals and regression results for groups with <5 individuals. While regression analyses were performed on all groups regardless of their size, privacy regulations prevented us from publishing their outcomes for Turkish-Dutch and Moroccan-Dutch dermatologists, and young male dermatologists with an Indonesian or Other migration background. This limits our ability to fully present the unequal odds these groups of physicians face in dermatology specialization."

Reviewer 2 (Gabriel Lazzeri Cortez)

Interpretive restraint in Discussion: The interpretation of associations should be more cautious. The study cannot determine whether disparities reflect structural barriers, self-selection, or other mechanisms. The Discussion occasionally moves beyond the data. Our response: We fully agree and have systematically revised the Discussion. We replaced evaluative language (e.g., "alarming", "inaccessible") with neutral terms, reframed causal claims as hypotheses, changed "increases odds of entering dermatology" to "is associated with higher odds of being a registered dermatologist," and added calls for further research throughout where causal interpretations were implied.

Tempering claims about clinical impact: Claims about patient outcomes and diagnostic accuracy should be presented as areas for future research rather than direct consequences. Our response: As part of the systematic revision described above, we have tempered all claims regarding clinical impact. Statements about misdiagnosis, care quality, and treatment outcomes are now framed as hypotheses rather than established causal links, and we have added explicit calls for further research to investigate these relationships in the Dutch context.

Policy recommendation: The recommendation for a centralized residency selection system should be presented more cautiously, as the study does not directly examine selection procedures. Our response: We have revised the Recommendations section to explicitly acknowledge that, consistent with previous research by Mulder et al. (2023), our study identifies persistent workforce homogeneity but cannot determine its causes. We now first support the call by Mulder et al. for a national registration system for residency training applications and outcomes. We have retained our suggestion for a centralized application system but reframed it as a potential measure, and added a call for further research into the role of selection procedures.

Limitations of "migration background" classification: This classification may not fully capture lived cultural or linguistic experience. Our response: We have added a paragraph to the Limitations section acknowledging that the Statistics Netherlands classification of migration background is based on country of birth and may not fully capture the diversity of lived cultural, linguistic, or ethnic experiences. We clarify that, consistent with previous research (Mulder et al., 2023), this measure should be understood as a proxy rather than a direct measure of cultural or linguistic identity.

Abstract, Study design: The study design should be explicitly stated early in the abstract. Our response: We have revised the opening of the Methods section in the abstract to explicitly state the study design as a "nationwide, population-based, repeated cross-sectional study," in accordance with STROBE Item 1(a).

Abstract, Comparison group: The comparison group in the regression analysis should be more clearly defined. Our response: We have revised the Methods section of the abstract to explicitly state that dermatologists were compared to all other registered physicians in the 2023 national healthcare professional register (BIG register).

Abstract, Odds ratios: The Results section should include at least one adjusted odds ratio with confidence interval. Our response: We have added the adjusted odds ratios with 95% confidence intervals for the younger generation of physicians in the abstract: "Multivariable regression analysis showed that being female (OR 1.609 [1.143–2.266]), having parents in the top 20% assets bracket (OR 2.251 [1.272–3.984]), or having physician parents (OR 1.326 [1.011-1.740]) were associated with higher odds of being a registered dermatologist among the younger generation of physicians."

Abstract, Concluding sentence: The conclusion should be moderated to avoid implying causal effects on patient care, given the cross-sectional design. Our response: We have revised the concluding sentence to frame the implications as exploratory, stating that the underrepresentation "may have implications for equitable patient care" and that "further research is warranted to explore the potential impact of workforce diversity on patient outcomes."

Academic Editor / Journal

Journal requirements: PLOS ONE style templates, table placement, financial disclosure, Data Availability statement, Supporting Information captions, reference check for retracted papers, and figure specifications. Our response: We have addressed all journal requirements: formatted the manuscript according to PLOS ONE style templates, placed tables appropriately, updated the financial disclosure and funder role statement, revised the Data Availability statement, added Supporting Information captions and updated in-text citations, checked all references for retracted papers, and ensured figures meet PLOS ONE technical specifications.

PLOS ONE style and formatting: The manuscript must meet PLOS ONE style requirements, including file naming conventions. Our response: We have formatted the manuscript according to PLOS ONE style templates and updated all file names accordingly.

Table placement: Tables should be included as part of the main manuscript. Supplementary tables should be uploaded separately as "supporting information" files. Our response: We have placed all main tables within the manuscript and uploaded supplementary tables as separate supporting information files.

Financial disclosure: Update the financial disclosure statement and clarify the role of the funders in the study. Our response: We have updated the financial disclosure statement, specifying that the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Data Availability statement: Update the Data Availability statement in the submission form. Our response: The updated Data Availability statement is as follows: The raw data that support the findings of this study are owned by Statistics Netherlands, and are accessible under certain conditions for statistical and scientific research. The authors of the manuscript do not own any raw data, and under Dutch law, it is not legal to publicly share these data. For further information about how to access the raw data, see the following Statistics Netherlands website: https://www.cbs.nl/en-gb/our-services/customised-services-microdata/microdata-conducting-your-own-research

Prior presentation or publication: We noted in your submission details that a portion of your manuscript may have been presented or published elsewhere. Please clarify whether this was peer-reviewed and formally published. If this work was previously peer-reviewed and published, in the cover letter please provide the reason that this work does not constitute dual publication and should be included in the current manuscript. Our response: We have expanded on this section, which now reads as follows: "This article is part of a comprehensive research project on diversity across all Dutch BIG-register healthcare occupations. While using consistent methodology across specialties, this paper presents unique dermatology-specific findings, including demographic data and regression analyses of physicians' odds of specializing in dermatology. Reference group data on the (young) physician pool will appear in other papers as well, as the extensive nature of the BIG-register (covering 35 medical specialties and 10 additional healthcare occupations) necessitated dividing findings across multiple publications. It is necessary to publish these physician data in each article, so that the diversity of the dermatology workforce can be compared to the diversity of the physician workforce, both by using their respective descriptive statistics and by the results of the regression analyses, which are performed on the total physician pool and the young physician pool. This does not constitute dual publication, since the physician pool is only the reference group to which the dermatology workforce is compared."

Supporting Information: Include captions for supporting information files and update any in-text citations to match the Supporting Information guidelines. Our response: We have added captions for all supporting information files and updated in-text citations to match PLOS ONE Supporting Information guidelines.

Reviewer-recommended publications: Evaluate whether publications recommended by reviewers are relevant and cite them if appropriate. Our response: Neither reviewer recommended specific publications for citation. No action was required for this item.

Reference list: Review the reference list to ensure it is complete, correct, and check for any retracted papers. Our response: We have reviewed the complete reference list and confirmed that no retracted papers are included. New references were added to the manuscript as a result of reviewer feedback, specifically to support the expanded discussion on intersectionality, see points above.

We trust that these revisions adequately address all comments raised and hope the revised manuscript is now suitable for publication in PLOS ONE.

Kind regards, on behalf of all authors,

Lianne Mulder, PhD

Corresponding Author

Attachments
Attachment
Submitted filename: Response to Reviewers.docx
Decision Letter - Gisele Viana de Oliveira, Editor

Who becomes a dermatologist? A repeated cross-sectional study on diversity in the Dutch dermatology workforce

PONE-D-25-63882R1

Dear Dr. Mulder

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Gisele Viana de Oliveira

Academic Editor

PLOS One

Additional Editor Comments (optional):

The authors carefully revised the manuscript to address all reviewer and editorial comments. They corrected language and formatting issues throughout the paper, clarified methodological points, and expanded the discussion on intersectionality and demographic disparities. They also added clearer explanations about limitations related to small subgroup analyses and the use of “migration background” as a proxy measure.

Discussion and Conclusions were rewritten in a more cautious and balanced way. Claims that could imply causation were softened, clinical implications were reframed as hypotheses requiring further research, and policy recommendations were presented more carefully.

The abstract was strengthened by explicitly stating the study design, clarifying the comparison group, and including adjusted odds ratios with confidence intervals.

Finally, the authors fully updated the manuscript to comply with PLOS ONE requirements, including formatting, tables, supplementary files, financial disclosure, data availability statements, figure specifications, and reference checks. They also clarified concerns regarding overlap with related publications from the same broader research project.

Formally Accepted
Acceptance Letter - Gisele Viana de Oliveira, Editor

PONE-D-25-63882R1

PLOS One

Dear Dr. Mulder,

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Academic Editor

PLOS One

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