Dear Dr. Sakata,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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We look forward to receiving your revised manuscript.

Kind regards,

Mari Kajiwara Saito, M.D., Ph.D.

Academic Editor

PLOS ONE

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When submitting your revision, we need you to address these additional requirements.

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3. If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise.

Additional Editor Comments:

Major comments: Have authors used AIs for drafting this manuscript? If so, it would be nice if the authors could include the statement on the use of generative AIs (which AI, in which step) in Acknowledgement section.

I assume the following is likely to be AI-generated text, because these phrases seem to have lost your tone and voice: L52-56, L60-64, p16 the last two lines-p17 the first two lines

All authors of this manuscript have responsibility for its originality. Generative AI cannot be an author, and verbatim (blanketly just copying and pasting the translated phrases) from generative AI is ethically contingent, may not be acceptable, and authors could be in danger of plagiarism without any intention. To maintain academic competency and research integrity, it is advisable that authors use generative AIs appropriately for this and further research.

Cheng A, Calhoun A, Reedy G. Artificial intelligence-assisted academic writing: recommendations for ethical use. Adv Simul (Lond). 2025;10(1):22.

Minor comments: the word “self-determined” has a different meaning. Please consider changing the word.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer #1: Partly

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2. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: No

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3. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

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Reviewer #1: Thank you for the opportunity to review this manuscript. I found the topic to be important and the effort to collect multicenter data commendable. However, there are several concerns regarding methodology, definitions, and clarity of reporting. Due to the length of my review, I have provided detailed comments in the attached document for the authors’ and editors’ consideration.

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what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #1: No

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Attachments

Attachment

Submitted filename: PLOS_Comments.docx

Clinical impact of hospital distance and center transfers on adherence and outcomes in familial adenomatous polyposis: A multicenter retrospective study in a defined region of Japan

PONE-D-25-45810R1

Dear Dr. Sakata,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Mari Kajiwara Saito, M.D., Ph.D.

Academic Editor

PLOS One

Additional Editor Comments (optional):

Congratulations on the acceptance of your study. I have a few minor comments on the revised manuscript.

1. L178: Univariate analyses of surveillance dropout were performed using logistic regression. & Table 2, S1 Table

• I am uncertain whether the authors used the term “univariate” in its conventional statistical meaning. Please clarify whether the term was intended to refer to a single outcome (univariate) or whether “univariable” (indicating a single exposure) would be more appropriate.
• The authors state that logistic regression was used, but in the Table 2 and S1 Table, hazard ratios are reported. Please clarify which statistical model was actually used.

2. The definition of metachronous CRC varies across countries and studies. I reckon the authors intended to define metachronous CRC using a 1-year cutoff, as specified by the Japanese Society for Cancer of the Colon and Rectum. Please specify how the metachronous CRC was defined in this study and provide an appropriate citation.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #1: (No Response)

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2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #1: (No Response)

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3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: (No Response)

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4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: (No Response)

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5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: (No Response)

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Reviewer #1: (No Response)

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what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #1: No

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