Dear Dr. zhang,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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We look forward to receiving your revised manuscript.

Kind regards,

Sarman Singh, MD, FRSC, FRCP

Academic Editor

PLOS ONE

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Additional Editor Comments :

1. In addition to suggestions from the reviewers, the authors are requested to improvise the English language requires a significant improvisation. For example but not limited to "xxx relative to pDST" should be changed to "xxx compared to pDST".

2. Also the refences are not in the proper formatting. "Organization WH" should be written as World Health Organization" or "WHO". There are many more grammatical errors.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: 1. In the results section, line 203 ”A total of 11 discrepant samples with 3 false-positive and 8 false-negative...."

I think this false negative result needs to be discussed in the discussion section.

2. In the results section, line 205 "17 false-positive or 5 false-negative..."

I think this false positive result needs to be discussed in the discussion section.

3. What criteria are used to determine that someone is suspected of having MDR-TB in the methods section?

Reviewer #2: Thank you for the manuscript. It was well-written and it is well-appreciated. From my side only few minor comments:

- Line 66-68: I would suggest to use updated information in the introduction part.

- Line 108-112: Clinically suspected MDR patients? The mentioned sentences are not clear, for instance what are the chances for a patient that would be smear positive and but clinically shows improvement?

- Line 254-255: “The sensitivity of second-line drugs remains insufficient, similar to or slightly lower than the results reported in other reports” Ref: [18-19]

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what does this mean? ). If published, this will include your full peer review and any attached files.

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Reviewer #1: Yes:  Tutik Kusmiati

Reviewer #2: Yes:  Ahmad Reza Yosofi

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Evaluation of the Xpert MTB/XDR test for detection of Isoniazid, Fluoroquinolones, and second-line injectable drugs resistance to Mycobacterium tuberculosis—Anhui Province, China

PONE-D-25-27893R1

Dear Dr. zhang,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Sarman Singh, MD, FRSC, FRCP

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: