Dear Dr. Deng,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please address the reviewers' comments as mentioned.

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We look forward to receiving your revised manuscript.

Kind regards,

Erik Su

Academic Editor

PLOS ONE

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Additional Editor Comments (if provided):

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: N/A

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3. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Thank you all for your work. It is clear you spent a great deal of time and effort putting together a well thought out review.

I do not have any major revisions for you to complete only small adjustments below:

- In your introduction near line 110 it appears the first sentence of the new paragraph is a repeat of the description/ definition of pulsatile flushing that is mentioned up above. Nothing major it just reads as if you are defining it twice.

- For table 2- I did not see outcome 17 listed as being used in the table. Perhaps it was just not assigned to a paper or you could just remove it as an outcome.

- On section 5.5 on flushing speeds it may be worth considering converting the 4 cm3/sec to ml/sec to have consistency in the labeling of units throughout the manuscript. Again, near sentence at number line 478.

- For table 3 for the last row under the column Gaps- would reword the sentence to read “… patency or prevent complications or damage to the endothelium”. Essentially removing the word damage again at the end.

- Around line number 490- For the data on shear rates- I could not see where ref 67 Dunkley et. al states specific shear rates related to platelet aggregation. And I didn’t see mention of them by Ref 65 Nicholson. Perhaps the reference numbers got shifted a little.

Overall, this is a great review of the literature and a good summary of what is available to us.

Reviewer #2: Very interesting topic reviewed, especially the section on fluid dynamics.

Only point is the possible grammatical error of line 78 and PVC used without the explanation of what it stands for. Was this intended to be PIVC? PVC is later used and explained in line 251.

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what does this mean? ). If published, this will include your full peer review and any attached files.

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Reviewer #1: No

Reviewer #2: No

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Flushing Peripheral Intravenous Catheters: A Scoping Review

PONE-D-25-22430R1

Dear Dr. Deng,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Erik Su

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: No additional comments. Thank you for your updates.

Reviewer #2: (No Response)

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what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #1: Yes:  Mark D. Weber MSN, RN, CRNP-AC, FCCM

Reviewer #2: No

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