-->PONE-D-25-21537-->-->Exploring the Torque- Velocity Relationship in Postmenopausal Women: Analyzing the Influence of Data Processing-->-->PLOS ONE

Dear Dr. Iglesias-Soler,

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“This study is part of the project PID2021-124277OB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and “ERDF/EU. M.R.A. and J.R.V. received financial support from the Spanish Ministry of Universities through the Grants for the Requalification of the Spanish University System under the Postdoctoral Margarita Salas Programme – Universidade da Coruña (RSUC.UDC.MS09 and RSUC.UDC.MS10, respectively). MRA also acknowledges the financial support received from the Xunta de Galicia (Consellería de Cultura, Educación, Formación Profesional y Universidades) through the Xunta de Galicia Postdoctoral Fellowships (ED481B ‐2024 ‐077). I.N. is supported by a predoctoral grant from Spanish Ministry of Science, Innovation and Universities (FPU23/03727). “

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“This study is part of the project PID2021-124277OB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and “ERDF/EU. M.R.A. and J.R.V. received financial support from the Spanish Ministry of Universities through the Grants for the Requalification of the Spanish University System under the Postdoctoral Margarita Salas Programme – Universidade da Coruña (RSUC.UDC.MS09 and RSUC.UDC.MS10, respectively). MRA also acknowledges the financial support received from the Xunta de Galicia (Consellería de Cultura, Educación, Formación Profesional y Universidades) through the Xunta de Galicia Postdoctoral Fellowships (ED481B ‐2024 ‐077). I.N. is supported by a predoctoral grant from Spanish Ministry of Science, Innovation and Universities (FPU23/03727). “

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Reviewers' comments:

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-->Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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-->2. Has the statistical analysis been performed appropriately and rigorously? -->

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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-->5. Review Comments to the Author

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Reviewer #1: In the article "Exploring the Torque- Velocity Relationship in Postmenopausal Women: Analyzing the Influence of Data Processing" authors discussed the linear and non-linear models for fitting the torque-velocity relationship in postmenopausal women. The article is well supported with faithful and adequate results. Hence, recommended for acceptance.

Reviewer #2: Dear Author.

This study aimed to compare linear and non-linear models for fitting the torque-velocity relationship in postmenopausal women and assess how data processing affects the results. 16 physically active postmenopausal women participated in the experiments. The obtained results are well presented and discussed, and therefore I accept the paper.

Reviewer #3: This study presents a valuable investigation into the torque-velocity (TV) relationship in postmenopausal women, offering significant insights into the influence of data processing methods and regression model selection on reported outcomes. While the study designs, protocols, statistical analysis, and corresponding findings are robust, I believe some minor revisions would further enhance its clarity and overall impact.

1. Experimental setup illustrations.

The detailed descriptions of the experimental setup are appreciated. However, incorporating visual aids, such as diagrams or photographs illustrating the participant's positioning and dynamometer attachement for both knee extensor and elbow flexor assesments, would greatly facilitate reader comprehension.

2. Rationale for Polonomial model (PM) selection.

The conclusion to recommend the PM for fitting TV data is well-supported by its superior goodness of fit and the issues identified with other models. To further address this, it would be veneficial to expand on the technical or physiological reasons why the PM is particularly well-suited to reflect the muscle's TV characteristics in this population, beyond just its model performance. A brief discussion of how PM effectively captures the nonlinear aspects of muscle force-velocity relationships, perhaps referencing relevant biomechanical principles or prior research that explains PM's physiological appropriateness, would add greater depth to this key conclusion.

3. The significance of T0 and V0 parameter.

The analysis and comparison of T0 and V0 are central to the study's findings regarding model selection and data processing. While the manuscript defines these parameters according to each model, their fundamental physiological and practical significance within muscle meachnics and why their compraison is crucial could be more explicitly articulated.

In summary, this is a well-conducted study, and the findings are important. I believe that by explicitly discussing the scientific rationale behind the findings, the manuscript could more effectively convey its insights and provide greater value to the readership. I apologize if my understanding was incomplete in certain areas, and I would appreciate any clarifications you could provide to address these points.

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Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

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While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/ . PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org . Please note that Supporting Information files do not need this step.-->

Exploring the Torque- Velocity Relationship in Postmenopausal Women: Analyzing the Influence of Data Processing

PONE-D-25-21537R1

Dear Dr. Iglesias-Soler,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Hasan Sozen

Academic Editor

PLOS ONE