Dear Dr. Afolabi,

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Paolo Magni

Academic Editor

PLOS ONE

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Additional Editor Comments:

The paper has been improved. We ask you to further address in full the issues raised by Reviewer 1.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: It is a very well written article regarding Predictive Ability Of Plasma Concentration Of Triglyceride/High Density Lipoprotein-Cholesterol Ratio For Cardiometabolic variables In A Sub-Sahara Black African Adolescent Population – Nigerians.

I want to congratulate the authors for their thorough effort.

I have only 2 comments to make.

1. In the Introduction part, they should include a more detailed discussion regarding the attributes and clinical usefulness of the TG/HDL ratio. A pertinent review article referring to the subject is:

Kosmas CE, Rodriguez Polanco S, Bousvarou MD, Papakonstantinou EJ, Peña Genao E, Guzman E, Kostara CE. The Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Risk Marker for Metabolic Syndrome and Cardiovascular Disease. Diagnostics (Basel). 2023 Mar 1;13(5):929. doi: 10.3390/diagnostics13050929. PMID: 36900073; PMCID: PMC10001260.

I feel that a brief discussion of the above review article and its addition to the references would be useful.

2. Since the authors appear to have the data of fasting plasma glucose of the population of their study, it would be very useful and would add to the complicity to the study if they would also examine the validity of the triglyceride glucose (TyG) index (another very well established index) on the same cardiometabolic variables and possibly compare the predictability of the TyG index with the predictability of the TG/HDL ratio. TyG index = Ln [TG (mg/dL) × fasting glucose (mg/dL)/2]. A pertinent article referring to this is:

Song K, Park G, Lee HS, Choi Y, Oh JS, Choi HS, Suh J, Kwon A, Kim HS, Chae HW. Prediction of Insulin Resistance by Modified Triglyceride Glucose Indices in Youth. Life (Basel). 2021 Mar 28;11(4):286. doi: 10.3390/life11040286. PMID: 33800541; PMCID: PMC8066260.

I feel that a brief discussion of the above review article and its addition to the references would also be useful.

Reviewer #2: This is an automated report for PONE-D-25-13856. This report was solicited by the PLOS One editorial team and provided by ScreenIT.

ScreenIT is an independent group of scientists developing automated tools that analyze academic papers. A set of automated tools screened your submitted manuscript and provided the report below. Each tool was created by your academic colleagues with the goal of helping authors. The tools look for factors that are important for transparency, rigor and reproducibility, and we hope that the report might help you to improve reporting in your manuscript. Within the report you will find links to more information about the items that the tools check. These links include helpful papers, websites, or videos that explain why the item is important. While our screening tools aim to improve and maintain quality standards they may, on occasion, miss nuances specific to your study type or flag something incorrectly. Each tool has limitations that are described on the ScreenIT website. The tools screen the main file for the paper; they are not able to screen supplements stored in separate files. Please note that the Academic Editor had access to these comments while making a decision on your manuscript. The Academic Editor may ask that issues flagged in this report be addressed. If you would like to provide feedback on the ScreenIT tool, please email the team at ScreenIt@bih-charite.de. If you have questions or concerns about the review process, please contact the PLOS One office at plosone@plos.org.

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what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #1: No

Reviewer #2: No

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Attachments

Attachment

Submitted filename: report_10.1101+2025.03.21.25324366.pdf

Predictive Ability Of Plasma Concentration Of Triglyceride/High Density Lipoprotein-Cholesterol Ratio For Cardiometabolic variables In A Sub-Sahara Black African Adolescent Population – Nigerians.

PONE-D-25-13856R1

Dear Dr. Afolabi,

<table border="0" cellpadding="0" cellspacing="0" class="datatable3"> <tbody> <tr> <td style="width:30%">To:</td> <td style="text-align:left;">Bamgboye M. Afolabi</td> </tr> </tbody></table><table border="0" cellpadding="0" cellspacing="0" class="datatable3"> <tbody> <tr> <td style="width:30%">To:</td> <td style="text-align:left;">Bamgboye M. Afolabi</td> </tr> </tbody></table>

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Paolo Magni

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

All reviewers' comments have been addressed.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

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Reviewer #1: The authors have adequately addressed the comments raised in the previous round of review and I feel that this manuscript is now acceptable for publication.

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what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #1: No

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