PONE-D-24-47755Global, regional, and national burden and trends of kidney cancer associated with high BMI from 1990 to 2021: findings from the Global Burden of Disease Study 2021PLOS ONE

Dear Dr. Zhao,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

The reviewers commend the manuscript for its comprehensive analysis of kidney cancer epidemiology, leveraging advanced statistical methods and highlighting the growing global burden linked to high BMI. Suggestions include improving table and figure quality and restructuring the discussion into multiple paragraphs for better readability and context.

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Wen-Wei Sung, M.D., Ph.D.

Academic Editor

PLOS ONE

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Additional Editor Comments (if provided):

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Reviewers' comments:

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: No

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: This paper is well written. The authors aim to provide the most current and comprehensive analysis of kidney cancer epidemiology by utilizing the latest data from the Global Burden of Disease 2021 study and employing advanced statistical methods, such as Estimated Annual Percentage Change projections. The results indicate that the global impact of kidney cancer associated with high BMI has expanded notably from 1990 to 2021, highlighting significant variations across different SDI regions, countries, and sexes. This increasing trend underscores the need for targeted interventions and public health strategies, particularly in regions and populations where kidney cancer prevalence is disproportionately high due to high BMI. These data are helpful in the clinical practice.

Reviewer #2: This manuscript is insightful and important since it is very rich in information and data. However, an improvements in the Table format and the quality of Figures provided in the article might enhance the quality of the manuscript.

Additionally, the discussion section might further be written in paragraphs, instead of using only single paragraph, to enhance the readability and to add more context to every important point stated in the discussion.

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Reviewer #1: No

Reviewer #2: Yes:  Besut Daryanto

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Global, regional, and national burden and trends of kidney cancer associated with high BMI from 1990 to 2021: findings from the Global Burden of Disease Study 2021

PONE-D-24-47755R1

Dear Dr. Zhao,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Wen-Wei Sung, M.D., Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: