Peer Review History

Original SubmissionMay 22, 2024
Decision Letter - Chung-Ta Chang, Editor

PONE-D-24-16170Exploring the Textural Characteristics of Foods Preferred by Chinese Elderly Individuals Based on IDDSI LevelsPLOS ONE

Dear Dr. Chen,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Jul 25 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Chung-Ta Chang

Academic Editor

PLOS ONE

Journal Requirements:

1. When submitting your revision, we need you to address these additional requirements.

Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at 

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and 

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

2. Please note that PLOS ONE has specific guidelines on code sharing for submissions in which author-generated code underpins the findings in the manuscript. In these cases, all author-generated code must be made available without restrictions upon publication of the work. Please review our guidelines at https://journals.plos.org/plosone/s/materials-and-software-sharing#loc-sharing-code and ensure that your code is shared in a way that follows best practice and facilitates reproducibility and reuse.

3. Thank you for stating the following financial disclosure: 

2023YFF1104405 Creation and industrialization demonstration of nutritious and healthy food for the elderly

Please state what role the funders took in the study.  If the funders had no role, please state: "The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." 

If this statement is not correct you must amend it as needed. 

Please include this amended Role of Funder statement in your cover letter; we will change the online submission form on your behalf.

4. We note that your Data Availability Statement is currently as follows: All relevant data are within the manuscript and its Supporting Information files.

Please confirm at this time whether or not your submission contains all raw data required to replicate the results of your study. Authors must share the “minimal data set” for their submission. PLOS defines the minimal data set to consist of the data required to replicate all study findings reported in the article, as well as related metadata and methods (https://journals.plos.org/plosone/s/data-availability#loc-minimal-data-set-definition).

For example, authors should submit the following data:

- The values behind the means, standard deviations and other measures reported;

- The values used to build graphs;

- The points extracted from images for analysis.

Authors do not need to submit their entire data set if only a portion of the data was used in the reported study.

If your submission does not contain these data, please either upload them as Supporting Information files or deposit them to a stable, public repository and provide us with the relevant URLs, DOIs, or accession numbers. For a list of recommended repositories, please see https://journals.plos.org/plosone/s/recommended-repositories.

If there are ethical or legal restrictions on sharing a de-identified data set, please explain them in detail (e.g., data contain potentially sensitive information, data are owned by a third-party organization, etc.) and who has imposed them (e.g., an ethics committee). Please also provide contact information for a data access committee, ethics committee, or other institutional body to which data requests may be sent. If data are owned by a third party, please indicate how others may request data access.

5. Please amend either the abstract on the online submission form (via Edit Submission) or the abstract in the manuscript so that they are identical.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Partly

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: Yes

Reviewer #3: Yes

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The Only Correction would be to do a ANOVA Or its Nonparametric Counterpart as multiple groups are thre based on data normality. Not much changes only the article will have more value and will be less of type 1 errors.

Reviewer #2: I would like congratulate the authors for producing good quality manuscript, but I have some queries and suggestions to increase the quality of the manuscript:

1. Kindly mention the study design of this manuscript.

2. Paired t was used in the study. It is a parametric test, was the normality of the data checked before applying this test. If so kindly mention.

3. Kindly upload high resolution images for figures.

4. Abstract is supposed to provide the gist of the manuscript. Kindly reduce the word count of your abstract.

5. Discussion should be less quantitative, kindly reduce the use of data in the discussions section and compare it with recent literature.

6. Discussion section can be elaborated after a thorough literature review.

7. Kindly provide the strengths and limitations of this study.

8. Kindly mention the future recommendations for this study

Reviewer #3: 1. Introduction

• The introduction clearly outlines the study's objective to explore the relationship between food texture characteristics and IDDSI levels among elderly Chinese individuals.

• The relevance of the study is well-established, highlighting the growing elderly population and the importance of addressing dysphagia through appropriate food textures.

• The introduction could benefit from a more thorough review of existing literature to contextualize the study within the broader field of dysphagia research.

• Explicitly stating the research questions or hypotheses could help to focus the study and guide the reader through the subsequent sections.

2. Methods

• The methods section provides detailed descriptions of how food hardness, cohesiveness, and adhesiveness were measured, ensuring reproducibility.

• The use of the IDDSI framework is appropriate and aligns the study with international standards for dysphagia diets.

• The sample size and selection criteria for the elderly participants should be explicitly stated. Details on the demographic characteristics of the participants (e.g., age range, gender distribution, health status) would enhance the study's generalizability.

• A more detailed explanation of the statistical methods used, including any assumptions made and how they were tested, would strengthen the rigor of the analysis.

3. Results

• The results are clearly presented with appropriate use of tables and figures to illustrate key findings.

• The results include statistical significance levels, providing a clear indication of which findings are most robust.

• Some sections of the results could benefit from more detailed descriptions. For instance, explaining why certain food categories showed significant changes in texture characteristics at specific IDDSI levels.

• Brief comparisons with existing studies in the results section could provide additional context and highlight the study's contributions to the field.

4. Discussion

• The discussion provides a thoughtful interpretation of the findings, linking changes in hardness, cohesiveness, and adhesiveness to the IDDSI levels and their implications for dysphagia management.

• The discussion effectively highlights the practical implications for food preparation and selection for elderly individuals with dysphagia.

• Providing specific practical guidelines or recommendations for food preparation based on the study's findings would be valuable for practitioners.

• A more detailed discussion of the study's limitations, including potential sources of bias and the generalizability of the findings, would provide a more balanced view.

5. Conclusion

• The conclusion succinctly summarizes the key findings and their implications for the preparation of dysphagia diets.

• The call for future research is well-articulated, emphasizing the need for further exploration of food texture characteristics and processing techniques.

• More specific recommendations for future research directions would be helpful. For example, suggesting specific food components or processing techniques to investigate.

• Discussing strategies for implementing the study's findings in real-world settings, such as in healthcare facilities or home care environments, would enhance the practical relevance of the research.

**********

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

Reviewer #3: Yes: Shivashankar Keingadarane

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Attachments
Attachment
Submitted filename: Reviewer Comments.docx
Revision 1

Dear Editor,

We would like to thank you and the reviewers for the thorough evaluation of our manuscript titled "Exploring the Textural Characteristics of Foods Preferred by Chinese Elderly Individuals Based on IDDSI Levels." We appreciate the constructive feedback provided and have addressed each point as outlined below:

1.Study Design:

We have clarified the study design in the revised manuscript. This study was conducted as a cross-sectional observational study aimed at exploring the texture characteristics of foods commonly preferred by elderly individuals in China using the IDDSI framework as a guide.

2.Normality Check for Paired t-Test:

Thank you for pointing this out. Upon reviewing our statistical methods, we realized that the initial datasets did not meet the normality assumption required for a parametric test like the paired t-test. Therefore, we have replaced the paired t-test with non-parametric alternatives, specifically the Mann-Whitney U test, and have updated the manuscript accordingly.

3.High-Resolution Images:

We have uploaded high-resolution versions of all figures as per your request.

4.Abstract Word Count:

The abstract has been revised to be more concise, providing a succinct summary of the key findings while reducing the word count as suggested.

5.Quantitative Data in Discussion:

We have revised the discussion section to be less quantitative. We have reduced the use of specific data points and instead focused on comparing our findings with recent literature to provide a more qualitative discussion.

6.Elaboration of Discussion with Literature Review:

The discussion section has been expanded to include a more thorough review of relevant literature, which has been incorporated to provide context and support for our findings.

7.Strengths and Limitations:

We have added a section discussing the strengths and limitations of the study. This includes the novelty of using web-scraping technology for data collection and the limitations related to the study’s reliance on a single data source and cross-sectional design.

8.Future Recommendations:

Future recommendations have been included in the revised manuscript, suggesting areas for further research, such as expanding data sources and conducting longitudinal studies to explore the causal relationships between food texture characteristics and swallowing safety.

We hope that these revisions meet your expectations, and we look forward to your feedback.

Sincerely,

Muxi Chen

Corresponding Author

Attachments
Attachment
Submitted filename: 2024.11.18.docx
Decision Letter - Chung-Ta Chang, Editor

PONE-D-24-16170R1Exploring the Textural Characteristics of Foods Preferred by Chinese Elderly Individuals Based on IDDSI LevelsPLOS ONE

Dear Dr. Chen,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Jan 29 2025 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Chung-Ta Chang

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #4: All comments have been addressed

Reviewer #5: (No Response)

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #4: Yes

Reviewer #5: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #4: Yes

Reviewer #5: I Don't Know

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #4: Yes

Reviewer #5: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #4: Yes

Reviewer #5: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #4: It seems to me that the revised version of the article has changed much and previous deficiencies do not remain. For these reasons, I can consider it for publication.

Reviewer #5: 2.5 Texture measurement methods- the machine used for testing needs to recognized by make and model.

2.3 Food processing continually repeating eg. "means egg-to-water ratio is 1:2. 2.3 first paragraph implies this clearly, thus does not need continual restatement.

Pg 56 A research supports - change to Previous research/#2.4 correct units is mL not ml.

Table 6 - requires unit for cohesion gf,

The predictive equation should be complimented with description from where the values were derived rather than relying on the reader recalling their existence in the text. e.g. values derived from the intercept values of the multiple linear regressions in Table 6 - values from adhesion, cohesion etc.

Figures lack explanation - the reader needs to be provided with some explanation such as ig. 1 the scope of hardness for seven food types displaying peaks for - colours make it difficult to distinguish in the document - please address.

Fig.2 Cohesiveness of seven food groups indicates extensive overlaps within th IDDSI levels,

Fig 3. Adhesiveness demonstrates distinct peaks for .....

Etc for other figures

Note some of the colours were difficult to distinguish in the manuscript and need serious review.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #4: No

Reviewer #5: Yes: Dr Graham Ellender

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Revision 2

Dear Editor and Reviewers,

We sincerely appreciate the time and effort you have invested in reviewing our manuscript and providing valuable feedback. We have carefully considered each comment and made the corresponding revisions to improve the clarity, accuracy, and overall quality of our work. Below, we detail our point-by-point responses to Reviewer #5’s comments and the specific changes implemented in the revised manuscript. Revised sections are clearly indicated in the updated version.

Reviewer #5’s Comments and Our Responses

1.Texture Measurement Methods (Section 2.5) - Instrument Make and Model

Comment: In Section 2.5, please provide the make and model of the texture analyzer used.

Response and Revision: We have added the specific make and model of the instrument. The text now reads: “Texture measurements were performed using a texture analyzer TA.new plus (ISENSO, USA).”

2.Repetition in Food Processing Description (Section 2.3)

Comment: The egg-to-water ratio (1:2) is repeated multiple times, though it is clearly stated in the first paragraph of Section 2.3. Avoid unnecessary repetition.

Response and Revision: We have removed all redundant mentions of the egg-to-water ratio, retaining only the initial statement in the first paragraph of Section 2.3

3.Wording and Unit Standardization

Comment: On page 56, “A research supports” should be changed to “Previous research supports.” Also, please use “mL” instead of “ml.”

Response and Revision: We have revised the sentence to “Previous research supports…” and have standardized all volume units to “mL” throughout the manuscript.

4.Unit for Cohesion in Table 6

Comment: Specify the unit for Cohesion in Table 6 (e.g., gf).

Response and Revision: We have updated Table 6, now labeling the Cohesion column as “Cohesion (gf).”

5.Predictive Equation Clarification

Comment: The predictive equation should include a clear explanation of where the values (e.g., intercepts from multiple linear regressions) are derived, rather than relying on the reader’s memory.

Response and Revision: We have revised the accompanying text for the predictive equation, explicitly stating that the intercepts and parameters (e.g., adhesion, cohesion) originate from the multiple linear regression analyses presented in Table 6. This clarification allows readers to fully understand the source of these values without referring back to earlier sections.

6.Figure Explanations and Color Improvements

Comment: The figures lack sufficient explanation, and the colors are difficult to distinguish. Each figure should provide more context. For example, Fig. 1 should explain the scope of hardness for the seven food types and indicate peaks. Similarly, Fig. 2 and Fig. 3 need more descriptive captions. Please also address the color contrast issues.

Response and Revision:

We have expanded and clarified the figure captions as follows:

Fig. 1 (Revised Caption): “This figure illustrates the hardness profiles of seven food categories. Each color corresponds to a distinct food group. Solid and dashed lines represent the maximum and minimum values, respectively, while the shaded area indicates the overall range. Peaks and distributions of hardness for each category are highlighted to facilitate comparisons.”

Fig. 2 (Revised Caption): “This figure shows the cohesiveness distributions of seven food groups across different IDDSI levels. Each color represents a distinct category. Solid and dashed lines indicate the maximum and minimum values, and the shaded area represents the range. Overlapping distributions highlight the complexity of categorizing these foods within IDDSI levels.”

Fig. 3 (Revised Caption): “This figure displays the adhesiveness values of seven food categories. Each color corresponds to a different group, with solid and dashed lines marking maximum and minimum values, and the shaded area showing the range. The figure reveals distinct peaks in adhesiveness, enabling straightforward comparisons among the categories.”

To address color differentiation issues, we have selected seven colors with higher contrast and employed a combination of solid and dashed lines, as well as shaded areas, to represent maximum, minimum, and range values. This approach ensures that readers can easily distinguish between categories, even when viewed in grayscale.

We thank you again for your constructive and insightful feedback. We believe that these revisions have substantially improved the manuscript’s clarity, coherence, and readability. If you have any further comments or suggestions, we will be happy to

address them.

Sincerely,

Chen Muxi

Attachments
Attachment
Submitted filename: Response to Reviewers.docx
Decision Letter - Chung-Ta Chang, Editor

Exploring the Textural Characteristics of Foods Preferred by Chinese Elderly Individuals Based on IDDSI Levels

PONE-D-24-16170R2

Dear Dr. Chen,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice will be generated when your article is formally accepted. Please note, if your institution has a publishing partnership with PLOS and your article meets the relevant criteria, all or part of your publication costs will be covered. Please make sure your user information is up-to-date by logging into Editorial Manager at Editorial Manager® and clicking the ‘Update My Information' link at the top of the page. If you have any questions relating to publication charges, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Chung-Ta Chang

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Formally Accepted
Acceptance Letter - Chung-Ta Chang, Editor

PONE-D-24-16170R2

PLOS ONE

Dear Dr. Chen,

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now being handed over to our production team.

At this stage, our production department will prepare your paper for publication. This includes ensuring the following:

* All references, tables, and figures are properly cited

* All relevant supporting information is included in the manuscript submission,

* There are no issues that prevent the paper from being properly typeset

If revisions are needed, the production department will contact you directly to resolve them. If no revisions are needed, you will receive an email when the publication date has been set. At this time, we do not offer pre-publication proofs to authors during production of the accepted work. Please keep in mind that we are working through a large volume of accepted articles, so please give us a few weeks to review your paper and let you know the next and final steps.

Lastly, if your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

If we can help with anything else, please email us at customercare@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Chung-Ta Chang

Academic Editor

PLOS ONE

Open letter on the publication of peer review reports

PLOS recognizes the benefits of transparency in the peer review process. Therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. Reviewers remain anonymous, unless they choose to reveal their names.

We encourage other journals to join us in this initiative. We hope that our action inspires the community, including researchers, research funders, and research institutions, to recognize the benefits of published peer review reports for all parts of the research system.

Learn more at ASAPbio .