PONE-D-24-35383Effects of high-intensity interval training versus moderate-intensity continuous training on cardiorespiratory and exercise capacity in patients with coronary artery disease: a systematic review and meta-analysisPLOS ONE

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Reviewers' comments:

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: No

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

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Reviewer #1: Yes

Reviewer #2: No

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Hello,

Thanks for submitting your manuscript titled Effects of high-intensity interval training versus moderate-intensity continuous training on cardiorespiratory and exercise capacity in patients with coronary artery disease: a systematic review and meta-analysis

to this journal. It is a well written manuscript however I have following observations and comments

1. The abstract mentions significantly better outcomes with treadmill as compared to cycle ergometry but the methods or results does not mention the parameters based on which the same was concluded. Hence it would be advisable either to remove this in abstract or substantiate it with the data in the results

2. P value for various parameters mentioned significant in comparison is mentioned >0.05 and though we understand it is the p value for interaction and not for test of significance, it needs to be mentioned explicitly how the significance was concluded as mentioning P value >0.05 in the same line without clarifying on the same makes it confusing.

3. Please review and add flowchart of methods of meta analysis

Thanks

Reviewer #2: Define PeakVO2 in the keywords rather than using an abbreviation.

In the ‘results’ section of the abstract, most of the abbreviations are not defined. This part is difficult to understand/read.

The corresponding author should use a professional email address: 1903222804@qq.com

The first paragraph of the introduction is long and not interesting because it is very general. I would recommend getting to physical activity more quickly.

In the introduction, the authors justify their study by explaining that the literature on the topic lacks precision on the duration of programmes, but to compare the 2 exercise modalities the most important thing is not the duration of the programmes (4 vs 16 weeks), but also the intensity and duration and frequency of session. MICT can be at 50, 60, 70% VO2peak and, depending on the studies, HIIT can also vary from 40 to 110% VO2peak. Similarly, the duration of the session (28 min vs 40 min) or the frequency (1 vs 5 session/week) is also important... Without these analyses, the conclusions are likely to be erroneous (see table 2).

In the method, it is surprising to see that 1668 were identified in June, and that the paper was submitted at the beginning of September, just three months later... with 153 which were evaluated for full-text reading.

The authors should clearly indicate how the Boolean operators were used to combine the keywords/concepts. It would be interesting to clearly indicate the ‘phrase’ used/inserted (in PubMed…), so that we can check. At the moment, I'm finding that the number of articles is very different from the number mentioned by the authors.

In my opinion, in general, the method needs to be developed. Although I am familiar with the PRISMA standards, it is not currently possible to replicate this meta-analysis. Each stage of procedure must be detailed.

In the results section, there are far too many figures. The article contains 10 figures, some of which include 4 sub-figures.

In the discussion, the authors should take into account the heterogeneity of the studies, and therefore be more cautious.

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Reviewer #1: Yes: Dr Kamal Sharma

Reviewer #2: No

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Effects of high-intensity interval training versus moderate-intensity continuous training on cardiorespiratory and exercise capacity in patients with coronary artery disease: a systematic review and meta-analysis

PONE-D-24-35383R1

Dear Dr. Yue,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Jeremy B. Coquart, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Hello,

The authors have addressed , revised and corrected the manuscript as per the review submitted. The manuscript is now improved and can be accepted in the revised format for publication.

Thanks

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Dr Kamal H sharma

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