PONE-D-24-05195Identifying children who develop severe chronic kidney disease using primary care recordsPLOS ONE

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Academic Editor

PLOS ONE

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Additional Editor Comments:

Dear Dr Lucy Plumb.

Thank you for the submission of your manuscript. It has been reviewed by two separate experts in the field and there are some concerns raised that need to be addressed.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: I Don't Know

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Here are my comments,

With exception of Table 2 and row 240, it is a bit unclear if the PPV is calculated for each type of symptoms or for combination of symptoms.

Row 14 - On the conclusion “positive predictive value of symptoms is low”, is the conclusion rather that “In combination, symptoms and consultation frequency demonstrated modest discrimination for CKD”?

Row 135 – On “there were 340 CYP with evidence of an incident severe CKD code in the primary care record, which were matched to 6,800 controls”, it would be more interesting with the numbers of CYP and controls that was used in the 24 months analysis and the 6 months analysis respectively.

Row 139 – Rater present the demographics table for the subjects included in the 24 months analysis and the 6 months analysis respectively.

Row - 163 Table 2, The heading “PPV per 1000” may be hard to understand, perhaps add a footnote of type ‘PPV 1.8 per 1000’ implies of 1,000 children coded, 2 would be diagnosed with severe CKD”.

Figure 1 – For the “6-month analyses” in panel a and b, should the text “registration less than 12 months” rather be “registration less than 6 months”?

Reviewer #2: It is a very relevant topic as it would begin monitoring & reversing some of the factors that can be reversed in chronic renal failure e.g. treatment of urinary tract infection diagnosis and management of hypertension, dietary manupulation, management of short stature and failure to thrive and delaying the onset of renal replacement therapy in theses chronic conditions.

To simplify the scoring system. I recognize that this was a study but for the general practitioners & general paediatricians, we need a simple algorithm.

It is a very relevant study.

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Reviewer #1: No

Reviewer #2: No

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Attachments

Attachment

Submitted filename: Review assignment for PONE-D-24-05195 20may2024.docx

Identifying children who develop severe chronic kidney disease using primary care records

PONE-D-24-05195R1

Dear Dr. Plumb,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Amjad Khan, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: I Don't Know

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Thank you for your response and revision.

Thank you for your response and revision.

Thank you for your response and revision.

Reviewer #2: It is a very important topic as detection of chronic renal disease earlier results in trying to preserve renal function long as possible, delying institution of renal replacement therapy.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

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